Generic Name: Zyvox
What is Zyvox?
Linezolid "pros" and "cons" Advantages:Mode of action Linezolid has a unique structure and mechanism of action, which targets bacterial protein synthesis i.
Linezolid is bacteriostatic against enterococci and staphylococci, and bactericidal for the majority of streptococci. Initially there were hopes that bacteria would be unable to develop resistance to linezolid. However, in 2003 Staphylococcus aureus was first identified as being resistant. Time to clear out of the system Linezolid half-life is 4-5. Further reading Linezolid Zyvox versus.
Linezolid vs Vancomycin References 1. Linezolid for the treatment of intractable multidrug-resistant and extensively drug-resistant tuberculosis. Garrabou G, Soriano A, Lopez S, Guallar JP, Giralt M, Villarroya F, Martinez JA, Casademont J, Cardellach F, Mensa J, Miro O. Reversible inhibition of mitochondrial protein synthesis during linezolid-related hyperlactatemia.
It only works when it comes to treating bacterial infections.
Safety information about this dangerous drug interaction is being added to the drug labels of Zyvox and serotonergic psychiatric medications. Patients taking psychiatric drugs are encouraged to discuss the risks associated with Zyvox with their healthcare professionals.
July 27, 2011 - According to a press release issued today, the U. Zyvox is an antibiotic medication used to treat different types of bacterial infections such as pneumonia, skin infections, and other infections that are resistant to antibiotics. It is a reversible monoamine oxidase inhibitor MAOIwhich prevents the action of monoamine oxidase A, an enzyme responsible for breaking down serotonin in the brain.
Although the specifics of the drug interaction are currently unknown, it is thought that when Zyvox is taken in combination with any of the psychiatric medications listed above, high levels of serotonin can build up in the brain, resulting in a toxic condition known as serotonin syndrome. Zyvox-induced serotonin syndrome is a rare but potentially life threatening drug interaction that causes the body to have too much serotonin, a brain chemical produced by nerve cells.
When used simultaneously, the drugs cause too much serotonin to be either released from or remain in the brain. Serotonin syndrome is most likely to occur immediately after the drugs are taken together. Signs and symptoms may include:According to the Mayo Clinic, treatment of serotonin syndrome varies widely from patient to patient and depends largely on the severity of the symptoms.
If your symptoms are minor, consulting your doctor and stopping the medicine may be enough to correct the problem. If you have symptoms that persist, you may need medical treatment.
How should I take Zyvox?
Ask your doctor when to start or stop taking this medication. Linezolid should not be used with any of these medications. This medication has been prescribed for your current condition only.
The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else.
A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
What should I avoid while taking Zyvox?
What brand names are available for linezolid-oral tablets. Is linezolid-oral tablets available as a generic drug. Do I need a prescription for linezolid-oral tablets. What are the uses for linezolid-oral tablets. Linezolid is used for treating pneumonia, complicated and uncomplicated skin and skin structure infections, and vancomycin-resistant Enterococcus faecium infections.
What are the side effects of linezolid-oral tablets. Cases of hypoglycemia have been reported during treatment with linezolid in patients with diabetes who are receiving insulin or oral hypoglycemic medications.
Zyvox side effects
ZYVOX is not indicated for the treatment of Gram-negative infections. Complicated skin and skin structure infections, including diabetic foot infections, without concomitant osteomyelitis, caused by Staphylococcus aureus methicillin-susceptible and -resistant isolatesStreptococcus pyogenes, or Streptococcus agalactiae.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of ZYVOX and other antibacterial drugs, ZYVOX should be used only to treat infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
The safety and efficacy of ZYVOX formulations given for longer than 28 days have not been evaluated in controlled clinical trials. The recommended dosage for ZYVOX formulations for the treatment of infections is described in Table 1.
Common Zyvox ide effects may include:
Interactions See also How to Use section.
Cure Rates at the Test-of-Cure Visit for Microbiologically Evaluable Adult Patients with Nosocomial Pneumonia Pathogen Table 17.
Therefore, it is important to consider this diagnosis in patients who develop serious diarrhoea during or after the use of linezolid.
It can increase the levels of certain natural substances in the body such as dopamine, norepinephrine, serotonin which can increase the chance of certain side effects and food and drug interactions.
Treatment-related adverse events reported in 1 percent or more of vancomycin patients were diarrhea 4. Deaths occurred in 18. Adverse events were considered treatment-related for 16. Treatment-related adverse events, serious adverse events and deaths were comparable for Zyvox and vancomycin.
Where can I get more information?
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Serotonergic Agents Dextromethorphan: The potential drug-drug interaction with dextromethorphan was studied in healthy volunteers.