Generic Name: Zyloprim
What is Zyloprim?
The serum concentration of the active metabolites of Azathioprine can be increased when Azathioprine is used in combination with Allopurinol. The risk of a hypersensitivity reaction to Allopurinol is increased when it is combined with Benazepril. The risk or severity of adverse effects can be increased when Allopurinol is combined with Bendamustine. The risk of a hypersensitivity reaction to Allopurinol is increased when it is combined with Bendroflumethiazide.
Bismuth Subcitrate can cause a decrease in the absorption of Allopurinol resulting in a reduced serum concentration and potentially a decrease in efficacy. The risk or severity of adverse effects can be increased when Bumetanide is combined with Allopurinol. Calcium carbonate can cause a decrease in the absorption of Allopurinol resulting in a reduced serum concentration and potentially a decrease in efficacy.
The risk of a hypersensitivity reaction to Allopurinol is increased when it is combined with Chlorthalidone. The risk of a hypersensitivity reaction to Allopurinol is increased when it is combined with Cilazapril. The risk or severity of adverse effects can be increased when Allopurinol is combined with Cyclophosphamide. The risk of a hypersensitivity reaction to Allopurinol is increased when it is combined with Enalapril.
GENERIC AVAILABLE: YesDo I need a prescription for allopurinol. YesWhat are the uses for allopurinol. Common side effects include: diarrhea, nausea, rash, itching, and drowsiness. See more info: allopurinol on RxList PREV 12 3 4 NEXT Need help identifying pills and medications. Psoriatic Arthritis Signs Systemic Lupus Diet Cortisone Injection Arthritis RSS Healthy Living Tips Health News Prevent or Slow Dementia GOP Health Care Plan Heart Disease and Fertility.
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How should I take Zyloprim?
United States of America Zyloprim About Sam W. High levels of uric acid in blood and recurring attacks of joint inflammation are the main symptoms of gout.
Lifestyle changes like weight loss, increasing fluid intake and dietary changes can help. Leishmaniasis Kala-azar refers to the spectrum of infectious disease produced by species of the Leishmania parasite. I have been taking one tablet of Zyloric for the last more than 10 years.
What should I avoid while taking Zyloprim?
Even with adequate therapy with ZYLOPRIM allopurinolit may require several months to deplete the uric acid pool sufficiently to achieve control of the acute attacks. A fluid intake sufficient to yield a daily urinary output of at least 2 liters and the maintenance of a neutral or, preferably, slightly alkaline urine are desirable to 1 avoid the theoretical possibility of formation of xanthine calculi under the influence of therapy with ZYLOPRIM allopurinol and 2 help prevent renal precipitation of urates in patients receiving concomitant uricosuric agents.
Some patients with pre-existing renal disease or poor urate clearance have shown a rise in BUN during administration of ZYLOPRIM allopurinol. Although the mechanism responsible for this has not been established, patients with impaired renal function should be carefully observed during the early stages of administration of ZYLOPRIM allopurinol and the dosage decreased or the drug withdrawn if increased abnormalities in renal function appear and persist.
Renal failure in association with administration of ZYLOPRIM allopurinol has been observed among patients with hyperuricemia secondary to neoplastic diseases. Concurrent conditions such as multiple myeloma and congestive myocardial disease were present among those patients whose renal dysfunction increased after ZYLOPRIM allopurinol was begun. Renal failure is also frequently associated with gouty nephropathy and rarely with hypersensitivity reactions associated with ZYLOPRIM allopurinol.
Zyloprim side effects
ZYLOPRIM allopurinol is a structural analogue of the natural purine base, hypoxanthine. It is an inhibitor of xanthine oxidase, the enzyme responsible for the conversion of hypoxanthine to xanthine and of xanthine to uric acid, the end product of purine metabolism in man. ZYLOPRIM allopurinol is metabolized to the corresponding xanthine analogue, oxipurinol alloxanthinewhich also is an inhibitor of xanthine oxidase.
It has been shown that reutilization of both hypoxanthine and xanthine for nucleotide and nucleic acid synthesis is markedly enhanced when their oxidations are inhibited by ZYLOPRIM allopurinol and oxipurinol. This reutilization does not disrupt normal nucleic acid anabolism, however, because feedback inhibition is an integral part of purine biosynthesis.
As a result of xanthine oxi-dase inhibition, the serum concentration of hypoxanthine plus xanthine in patients receiving ZYLOPRIM allopurinol for treatment of hyperuricemia is usually in the range of 0. A maximum of 0. The renal clearance of hypoxanthine and xanthine is at least 10 times greater than that of uric acid.
Common Zyloprim ide effects may include:
In patients with pre-existing liver disease, periodic liver function tests are recommended during the early stages of therapy.
It is populary known as Zyloric.
The negative side effects also range from minor to serious conditions.
Also tell them about any supplements you take.
Allopurinol and its metabolites are structural analogues of both purines and pyrimidines and thus can affect enzymes in both purine and pyrimidine metabolic pathways, whereas febuxostat is a non-purine inhibitor of XO only. Since allopurinol is a purine analogue, it also undergoes metabolism by XO, which results in the production to its most active metabolite oxypurinol. Since febuxostat is not a structural analogue of either purines or pyrimidines, it does not interfere with the activity of these other pathways.
Do these pharmacologic principles translate into any differences in the reduction of serum uric acid levels. However, it is imperative that clinicians recognize that both allopurinol and febuxostat can inhibit the XO-mediated metabolism of azathioprine Imuranthereby putting patients at an increased risk for life-threatening bone marrow suppression.
Where can I get more information?
As Zyloprim normalizes uric acid production in the body, it is primarily used for the treatment and prevention of kidney problems and gout, as mentioned above.
A maximum of 0.