Generic Name: Zovirax
What is Zovirax?
The Collaborative Acyclovir Varicella Study Group. Barry DW, Blum MR. Antiviral drugs: acyclovir, in Recent Advances in Clinical Pharmacology. Pharmacological and Clinical Approaches to Herpesviruses and Virus Chemotherapy, Aiso, Japan, September 10-13 1984. Barry DW, Nusinoff-Lehrman S, Ellis MN, Biron KK, Furman PA.
Viral resistance, clinical experience. Multiple dose pharmacokinetics of intravenous acyclovir in patients on continuous ambulatory peritoneal dialysis. Bryson YJ, Dillon M, Lovett M, Acuna G, Taylor S, Cherry JD et al. Treatment of first episodes of genital herpes simplex virus infection with oral acyclovir. Christophers J, Sutton RN.
Characterisation of acyclovir-resistant and -sensitive clinical herpes simplex virus isolates from an immunocompromised patient.
Neonates were removed from each group for necropsy and microscopic evaluation of a wide variety of tissues, including eyes and multiple sections of brain, after they had been treated for 5, 12 or 19 days and after a 3-week postdose drug-free period at which time they were 45 days of age.
Hematologic hemoglobin, packed cell volume, RBC, WBC and differential cell counts and clinical chemistry BUN tests were done after 16 days of treatment and repeated 18 days after the last 19th dose was given. Blood was collected from some neonates 30 minutes after treatment on day 1, on day 9 and at the end of the dose period for the determination of concentrations of acyclovir in plasma. The largest concentration of acyclovir in plasma was 99.
This finding may be of biological importance because there were minimal accumulations of nuclear debris in renal collecting ducts and loops of Henle in kidney sections taken from high-dose neonates after 19 days of treatment and examined by light microscopy.
This was the only time period and the kidney was the only organ in which minimal effects on developing organ systems were detected. Eye examinations and light microscopy did not reveal adverse effects on ocular development. It should be emphasized that there was no morphologic or functional evidence of adverse effects on developing brain or other portions of the central nervous system.
Thus, acyclovir is distinctly different than cytosine arabinoside which was reported to produce prominent cerebellar and retinal dysplasia in neonatal rats. All studies were performed both in the presence and absence of exogenous mammalian metabolic activation. Inconclusive results with no apparent dose-related response were obtained when acyclovir mutagenicity was studied at each of 3 loci APRT, HGPRT and Ouabain-resistance in Chinese hamster ovary CHO cells, both in the presence and absence of exogenous metabolic activation.
The morphologically transformed foci have been shown to grow as tumours following transplantation into immunosuppressed, syngeneic, weanling mice. Tumour tissues were diagnosed as being either undifferentiated sarcomas or lymphosarcomas.
Acyclovir, at concentrations of 62. There was also a significant dose-related decrease in mitotic index with exposure to acyclovir.
How should I take Zovirax?
Your symptoms may get better before the infection is completely treated. Treatment with Zovirax should be started as soon as possible after the first appearance of symptoms such as tingling, burning, blisters. Herpes infections are contagious and you can infect other people, even while you are being treated with Zovirax.
Avoid letting infected areas come into contact with other people. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Herpes can be passed to your baby during childbirth if you have a genital lesion when your baby is born. If you have genital herpes, it is very important to prevent herpes lesions during pregnancy.
What should I avoid while taking Zovirax?
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Zovirax side effects
Acyclovir belongs to a class of drugs called antivirals. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
Acyclovir works by lowering the ability of the herpes virus to multiply in your body. This treats the symptoms of your infection. Herpes infections include cold sores, chickenpox, shingles, or genital herpes.
Common Zovirax ide effects may include:
However, limited clinical investigation has revealed no evidence of a significant change in in vitro susceptibility of VZV with acyclovir therapy, although resistant mutants of this virus can be isolated in vitro in a manner analogous to HSV.
October 6, 2003 at 8:26 am 139641 biddy55Participant Thanks a million everyone for your replies - my mind is definitely more at ease.
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It may harm them. You can ask your pharmacist or healthcare provider for information about ZOVIRAX Cream that is written for health professionals. What are the ingredients in ZOVIRAX Cream.
For adolescents 12 years of age and older, the dosage is the same as in adults. The safety profile in patients 12 to 17 years of age was similar to that observed in adults.
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We explain everything you should know By Rita Ghelani Be informed.
Cream 10g but will be referred to as Zovirax.