Generic Name: Zomig
What is Zomig?
Tramadol: Data from small studies indicate that ondansetron may reduce the analgesic effect of tramadol. Breast-feedingTests have shown that ondansetron passes into the milk of lactating animals.
It is therefore recommended that mothers receiving Zofran should not breast-feed their babies. FertilityThere is no information on the effects of ondansetron on human fertility. The following frequencies are estimated at the standard recommended doses of ondansetron.
In the majority of cases, symptoms were similar to those already reported in patients receiving recommended doses see section 4. Ondansetron prolongs the QT interval in a dose-dependent fashion. Cases consistent with serotonin syndrome have been reported in young children following oral overdose.
TreatmentThere is no specific antidote for ondansetron, therefore in all cases of suspected overdose, symptomatic and supportive therapy should be given as appropriate. The use of ipecacuanha to treat overdose with ondansetron is not recommended, as patients are unlikely to respond due to the anti-emetic action of ondansetron itself.
Hypersensitivity to any component of the preparation. Respiratory events should be treated symptomatically and clinicians should pay particular attention to them as precursors of hypersensitivity reactions. Ondansetron prolongs the QT interval in a dose-dependent manner see Section 5. Avoid ondansetron in patients with congenital long QT syndrome.
Ondansetron should be administered with caution to patients who have or may develop prolongation of QTc, including patients with electrolyte abnormalities, congestive heart failure, bradyarrhythmias, conduction disturbances and in patients taking anti-arrhythmic agents or beta-adrenergic blocking agents or other medicinal products that lead to QT prolongation or electrolyte abnormalities. Hypokalemia and hypomagnesemia should be corrected prior to ondansetron administration.
There have been post-marketing reports describing patients with serotonin syndrome including altered mental status, autonomic instability and neuromuscular abnormalities following the concomitant use of ondansetron and other serotonergic drugs including selective serotonin reuptake inhibitors SSRI and serotonin noradrenaline reuptake inhibitors SNRIs.
If concomitant treatment with ondansetron and other serotonergic drugs is clinically warranted, appropriate observation of the patient is advised. As Zofran is known to increase large bowel transit time, patients with signs of subacute intestinal obstruction should be monitored following administration.
In patients with adenotonsillar surgery prevention of nausea and vomiting with ondansetron may mask occult bleeding. Therefore, such patients should be followed carefully after ondansetron. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Paediatric PopulationPaediatric patients receiving ondansetron with hepatotoxic chemotherapeutic agents should be monitored closely for impaired hepatic function. The comparative efficacy of these two different dosing regimens has not been investigated in clinical trials.
How should I take Zomig?
Since it is known to suppress the release of serotonin and force the stomach to empty faster, it is considered to help a person avoid the likelihood of vomiting. Furthermore, GlaxoSmithKline had educated doctors to view Zofran as an effective and appropriate antiemetic, or anti-nausea drug and allegedly encouraged them to promote it.
Though this may seem to make sense in theory, many controversial facts about the drug have surfaced over the last several years. It is important to note that the FDA still never approved ondansetron for use by pregnant women. Despite this questionable evidence, more than one million pregnant women were prescribed Zofran in 2013. Many women who have suffered medical conditions and have watched their children endure defects after being prescribed Zofran have taken action.
However, the Justice Department took the first step by suing the company for illegally promoting and marketing the drug to pregnant women in addition to several other infractions.
What should I avoid while taking Zomig?
Do not share this product with others. Consult your doctor for more details. Try to take each dose at the scheduled time. If you miss a dose, take it as soon as remembered unless it is near the time for the next dose.
In that case, skip the missed dose and resume your usual dosing schedule.
Zomig side effects
The most common adverse effects, according to the FDA, are headache, fatigue, constipation, and diarrhea. However, much more severe conditions can result from taking Zofran, including serotonin syndrome and arrhythmia, each of which can result in death. These are just a few of the most severe side effects of Zofran.
Get more information about Zofran side effects, complications, and interactions here. In 2015, Novartis purchased the oncology division of GlaxoSmithKline, and as a result Novartis is now also named as a defendant in lawsuits claiming Zofran-related damages after March 23, 2015.
Common Zomig ide effects may include:
Since patients less than 6 months of age will only receive a single dose in post-operative nausea and vomiting a decreased clearance is not likely to be clinically relevant.
The dose of Zofran is decreased for people who have poor liver function hepatic function.
In addition to adverse events reported from clinical trials, the following events have been identified during post-approval use of oral formulations of ZOFRAN.
If your child vomits an ODT dose, do not repeat it.
If these effects are mild, they may go away within a few days or a couple of weeks. Call your doctor right away if you have serious side effects. An interaction is when a substance changes the way a drug works.
Where can I get more information?
Last year the American College of Obstetricians and Gynecologists revised its practice bulletin, urging doctors to prescribe Diclegis as the first line of defense against NVP and ondansetron only after weighing the benefits against the risks.
The kidneys of older adults may not work as well as they used to.