Generic Name: Zofran
What is Zofran?
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Zofran is an anti-nausea drug administered to many chemotherapy and radiation patients while they undergo treatment. Nausea occurs when your body produces a signaling chemical called serotonin to induce nausea in response to treatment. This signal binds to a receptor in your body, which triggers the nausea. Zofran works by blocking the serotonin receptor, thus preventing the response. These side effects include blurred vision, anxiety, and fainting.
For moderately emetogenic chemotherapy, one 8 mg film should be taken 30 minutes before, followed by an 8 mg film eight hours later and an additional film every 12 hours for a day or two after the conclusion of chemotherapy is recommended.
For postoperative nausea and vomiting, the appropriate Zuplenz dose is 16 mg, given as two 8 mg films 1 hour before the administration of anesthesia. The Zuplenz package insert also notes that for patients with severely impaired liver function, the total daily dose of Zuplenz should not exceed 8 mg. Sanger GJ September 2008.
Oregon State University College of Pharmacy 2003. Please click here if you are not redirected within a few seconds. Jump To Topic Cases of serotonin syndrome, a potential side effect of having too much serotonin in the body, have been reported with the use of Zofran and Zuplenz, and some cases were fatal.
Medicines that Can Cause Problems When Taken with Zofran and Zuplenz Certain medications used in combination with Zofran or Zuplenz can cause serotonin syndrome. Prevention of nausea and vomiting associated with radiotherapy in patients receiving total body irradiation, single high-dose fraction to the abdomen, or daily fractions to the abdomen. Prevention of post-op nausea and vomiting. Highly emetogenic chemotherapy: 24mg once 30 mins before start of single-day chemotherapy multi-day, single-dose not studied.
Moderately emetogenic chemotherapy: 8mg every 8hrs for 2 doses beginning 30 mins before chemotherapy, then 8mg every 12hrs for 1-2 days after chemotherapy completed. Total body irradiation: 8mg 1-2hrs before each fraction of radiotherapy administered each day.
How should I take Zofran?
Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you. Connect with people like you, and get expert guidance on living a healthy life. This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment chemotherapy and radiation therapy.
It is also used to prevent and treat nausea and vomiting after surgery. It works by blocking one of the body's natural substances serotonin that causes vomiting.
To prevent nausea from chemotherapy, take this medication by mouth usually within 30 minutes before treatment begins.
What should I avoid while taking Zofran?
You could have dangerous levels of the drug in your body. If your symptoms are severe, call 9-1-1 or go to the nearest emergency room right away. There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you. Show Sources Content developed in collaboration with University of Illinois-Chicago, Drug Information GroupMedically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on January 14, 2016 Let us know how we can improve this article.
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Zofran side effects
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Common Zofran ide effects may include:
It was found guilty for illegal marketing when they promoted the sale and unsafe use of Zofran for conditions other than that which was FDA approved.
Zofran can cause headaches, tiredness, and constipation.
It is considered that adequate stability would also be conferred by the use of polyethylene infusion bags or Type 1 glass bottles.
Quick GuidePancreatic Cancer Symptoms, Causes, and Treatment Report Problems to the Food and Drug Administration You are encouraged to report negative side effects of prescription drugs to the FDA.
There is little consensus in the medical community about whether or not Zofran causes birth defects at present. However, a January 2012 study from the Center for Birth Defects Research and Prevention indicates that women taking Zofran for nausea and vomiting during the first trimester of pregnancy were twice as likely to give birth to a child with a cleft lip or cleft palate.
A more recent study published in Reproductive Toxicology presents possible links between the use of Zofran and specific birth defects that affect the heart as well.
Where can I get more information?
The purpose of this report is to retrieve and review existing evidence comparing the efficacy of different antiemetics for treatment of opioid-induced nausea.
Based on this analysis, systemic exposure AUC of ondansetron following oral or IV dosing in children and adolescents was comparable to adults, with the exception of infants aged 1 to 4 months.