Generic Name: Zocor
What is Zocor?
Muscle injury has long been recognized as a possible statin side effect, and the labels of these medications all bear warnings regarding this risk.
In 2010, the U. Food and Drug Administration FDA updated the labels of high-dose simvastatin to warn of an association with muscle injuries. On June 8, 2011, the FDA added new warnings to the labels of Zocor and other simvastatin cholesterol-lowering drugs and recommended that patients not be prescribed the 80 mg dose during the first 12 months of treatment in order to mitigate the Zocor muscle injury risk.
The new restrictions and warnings also apply to Vytorin and Simcor. In addition, the labels for simvastatin, Vytorin and Simcor were changed to include new dosing recommendations when these drugs are used with certain medications, such as blood pressure medicines amlodipine and diltiazem, which interact to increase the level of simvastatin in the body, which can increase the risk for myopathy. The FDA's action was prompted by a seven-year study and patient reports that prove those taking the higher dosage of simvastatin have a greater risk of muscle injury than patients treated with lower doses or other statins.
The agency said its review of a trial called the Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine SEARCH revealed 52 cases of myopathy occurring in the group of patients treated with 80 mg simvastatin versus one in the group treated with 20 mg.
And the restriction applies to Simcor, a combination pill sold by Abbott Laboratories. Simcor has lower levels of simvastatin, but may cause higher levels in the body interacting with other drugs, like blood pressure medicines amlodipine and diltiazem.
Muscle aches have long been known as a possible side effect of statins. On Wednesday, it said a seven-year study and patient reports prove that patients taking the higher dosage have a higher risk of muscle injury than those taking a lower dose of the drug or taking other statins. The high doses accounted for 11. A big reason is the rise of generics. Analysts expect drug advertising to continue to fall as more brand-name drugs face generic competition.
Issues Safety Alert on Zocor Subscribe Now Log In 0 Settings Close search Site Search Navigation Search NYTimes. See next articles Supported by Search By Duff Wilson June 8, 2011 3:58 pm June 8, 2011 3:58 pmThe Food and Drug Administration on Wednesday announced new safety restrictions on high-dose simvastatin, also known as Zocor, a cholesterol-lowering drug taken by an estimated 2.
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How should I take Zocor?
My husband takes Zocor 20mg for his hyperlipidemia. My husband suffers from high blood lipids and he is treated with Zocor Simvastatin. By accident he took 3 pills 60mg in one day. You need to call your GP.
Zocor doses are between 20-80 mg but maybe your husband has other problems mainly in his kidneys that will interfere with the normal way of cleaning the body from the drug. Zocor overdose symptoms will be myalgia and red urine in a severe overdose if your husband have one of those symptoms go to the ER as soon as possible.
What should I avoid while taking Zocor?
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Zocor side effects
Possible side effects include headache, constipation, and stomach pain. Your Guide to Healthy Living With DiabetesGet tips, read articles, and learn about healthy living with diabetes, in-depth, from eMedTV's experts. Click Zocor Uses for more information, including possible off-label uses. Zocor has also been approved for use in children ages 10 to 17 for the treatment of high cholesterol. Zocor is part of a class of drugs called statins.
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Common Zocor ide effects may include:
Its structural formula is: Simvastatin is a white to off-white, nonhygroscopic, crystalline powder that is practically insoluble in water, and freely soluble in chloroform, methanol and ethanol.
Diabetes is a chronic condition characterized by high levels of sugar glucose in the blood.
Pfizer's earnings decline on rising dollar, genericssaid Tuesday it anticipates posting a higher profit in the first quarter than originally expected because of strong sales of its cholesterol drug, Zocor.
The recommended starting dose for Lipitor is 10 or 20 mg once daily depending on the condition of the patient.
All patients treated with ZOCOR should be advised to report promptly any symptoms that may indicate liver injury, including fatigue, anorexia, right upper abdominal discomfort, dark urine or jaundice. Women of childbearing age should be advised to use an effective method of birth control to prevent pregnancy while using ZOCOR. Discuss future pregnancy plans with your patients, and discuss when to stop taking ZOCOR if they are trying to conceive.
Patients should be advised that if they become pregnant they should stop taking ZOCOR and call their healthcare professional.
Women who are breastfeeding should not use ZOCOR.
Where can I get more information?
According to the prescribing information, during clinical trials of Zocor, patients reported experiencing several gastrointestinal adverse reactions associated with treatment.
It is important for you to keep a written list of all of the prescription and nonprescription over-the-counter medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements.