Generic Name: Zithromax dispersible
What is Zithromax Dispersible?
In Study 174, 223 patients randomized to receive rifabutin, 223 patients randomized to receive azithromycin, and 218 patients randomized to receive both rifabutin and azithromycin met the entrance criteria.
The difference rifabutin - azithromycin in the one-year rates 7. The comparable number of patients experiencing adverse events and the fewer number of patients lost to follow-up on rifabutin should be taken into account when interpreting the significance of this difference. In Study 174, sensitivity testing5 was performed on all available MAC isolates from subjects randomized to either azithromycin, rifabutin, or the combination.
The distribution of MIC values for azithromycin from susceptibility testing of the breakthrough isolates was similar between trial arms. As the efficacy of azithromycin in the treatment of disseminated MAC has not been established, the clinical relevance of these in vitro MICs as an indicator of susceptibility or resistance is not known. In association with the decreased incidence of bacteremia, patients in the groups randomized to either azithromycin alone or azithromycin in combination with rifabutin showed reductions in the signs and symptoms of disseminated MAC disease, including fever or night sweats, weight loss, and anemia.
In Study 155, discontinuations for drug-related toxicity occurred in 8. In Study 174, more subjects discontinued from the combination of azithromycin and rifabutin 22.
First, patients were not randomized to the antibacterial drugs studied, so patients who received different drugs might have differed in ways that could have biased the results.
Second, the study only examined antibacterial drugs used in an outpatient setting, so it is likely that few patients were being treated for severe or life-threatening infections. Third, cardiovascular deaths were determined using death certificates rather than full medical records.
The increase in total deaths was due to cardiovascular deaths and not due to an increase in deaths from other causes. The excess risk of cardiovascular death, especially of sudden death, is consistent with arrhythmias from drug-related QT prolongation. FDA also evaluated the results of a clinical QT study conducted by the manufacturer assessing the effects of azithromycin on the QT interval in adults. The results of the study indicated that azithromycin prolonged the QTc interval. Information regarding the results of the QT study has been added to the Zithromax drug label.
Ray WA, Murray KT, Hall K, et al. Azithromycin and the risk of cardiovascular death. Regular Mail: Use postage-paid FDA Form 3500This website has been translated to Spanish from English, and is updated often.
How should I take Zithromax Dispersible?
Zithromax is indicated to treat several bacterial infections. Some of the possible side effects associated with Zithromax treatment include mild nausea, vomiting, diarrhea, constipation, stomach pain or upset, headache, dizziness, feeling tired, difficulty sleeping, nervousness, mild itching or skin rash, vaginal itching or discharge, decreased sense of taste or smell and ringing in your ears. Zithromax may be taken with or without food. If Zithromax upsets your stomach, take it with food.
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What should I avoid while taking Zithromax Dispersible?
The white blood cells take the medicine to the front lines of their struggle with germs, where it becomes concentrated in the tissues surrounding the infection.
That concentration helps it remain in the body longer, which means patients need fewer doses to beat their infections. But, Zithromax comes in several dosages and forms, including oral tablets and liquids for oral use, injections and intravenous drips. A doctor determines the dose depending on the infection being treated. For example, for pneumonia, pharyngitis or skin infections the recommended dose is the standard 500 mg for the first day and 250 mg for the remaining 4 days.
For more complicated disease such as acute sinusitis, doctors prescribe 500 mg a day for three days. In the case of sexually transmitted diseases, the dose is 1 gram, or 1000 mg, in one single dose.
According to the medication insert, certain people should not take Zithromax.
Zithromax Dispersible side effects
Contact your doctor or health care provider right away if any of these apply to you. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you: if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have liver or kidney problems, myasthenia gravis, or abnormal heart rhythms.
Some medicines may interact with Zithromax. Tell your health care provider if you are taking any other medicines, especially any of the following: Antiarrhythmics eg, disopyramide, dofetilidearsenic, astemizole, cisapride, domperidone, maprotiline, methadone, paliperidone, pimozide, propafenone, quinolone antibiotics eg, levofloxacinterfenadine, or tetrabenazine because the risk of heart problems, including irregular heartbeat, may be increased Nelfinavir because it may increase the risk of Zithromax's side effects Rifampin because it may decrease Zithromax's effectiveness Anticoagulants eg, warfarincarbamazepine, cyclosporine, digoxin, ergot derivatives eg, ergotaminenilotinib, phenytoin, rifampin, theophylline, triazolam, or tyrosine kinase receptor inhibitors eg, dasatinib because the risk of their side effects may be increased by Zithromax.
This may not be a complete list of all interactions that may occur. Important safety information: Zithromax may cause drowsiness, dizziness, blurred vision, or lightheadedness.
Zithromax may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Zithromax.
Common Zithromax Dispersible ide effects may include:
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
Clostridium Difficile-Associated Diarrhea CDAD CDAD has been reported with use of nearly all antibacterial agents, including ZITHROMAX, and may range in severity from mild diarrhea to fatal colitis.
It can also be used to prevent MAC infection.
In common with many other antibiotics Zithromax Capsules should be taken at least one hour before or 2 hours after food.
Be sure your health care provider knows about all the medications and supplements you are taking. Your health care provider may need to monitor you carefully if you are taking azithromycin and the protease inhibitor ritonavir.
In their Zithromax warning, the FDA said the antibiotic can alter the electrical activity of the heart, which in turn can lead to a fatal heart rhythm or sudden Zithromax deaths.
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Although a causal relationship has not been established, consideration should be given to the frequency of monitoring prothrombin time when azithromycin is used in patients receiving coumarin-type oral anticoagulants.