Generic Name: Zithromax dispersible
What is Zithromax Dispersible?
Discuss any questions or concerns about azithromycin or other antibacterial drugs with your health care professional. Seek immediate care if you experience an irregular heartbeat, shortness of breath, dizziness, or fainting while taking azithromycin.
Additional Information for Health Care Professionals Health care professionals should consider the risk of torsades de pointes and fatal arrhythmia when considering treatment options with azithromycin or alternative antibacterial drugs.
Groups at higher risk include: Patients with known prolongation of the QT interval, a history of torsades de pointes, congenital long QT syndrome, bradyarrhythmias, or uncompensated heart failurePatients on drugs known to prolong the QT intervalPatients with ongoing proarrhythmic conditions such as uncorrected hypokalemia or hypomagnesemia, clinically significant bradycardia, and in patients receiving Class IA quinidine, procainamide or Class III dofetilide, amiodarone, sotalol antiarrhythmic agents.
Elderly patients and patients with cardiac disease may be more susceptible to the effects of arrhythmogenic drugs on the QT interval. The potential risk of QT prolongation should be placed in appropriate context when choosing an antibacterial drug: Alternative drugs in the macrolide or fluoroquinolone drug classes also have the potential for QT prolongation or other significant side effects that should be considered when choosing an antibacterial drug.
Data SummaryThe study published in NEJM suggested a higher risk of cardiovascular deaths and deaths from any cause in persons treated with a 5-day course of azithromycin compared to persons treated with amoxicillin, ciprofloxacin, or no drug.
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Zithromax azithromycinalso known as Z-Pak, is an antibiotic that treats a number of infections. Approved by the FDA in 1992, doctors first used it to treat respiratory and skin infections.
ZITHROMAX for injection contains the active ingredient azithromycin, an azalide, a subclass of macrolide antibacterial drug, for intravenous injection. ZITHROMAX for injection consists of azithromycin dihydrate and the following inactive ingredients: citric acid and sodium hydroxide. Reconstitution, according to label directions, results in approximately 5 mL of ZITHROMAX for intravenous injection with each mL containing azithromycin dihydrate equivalent to 100 mg of azithromycin.
Co- administration of azithromycin increased the QTc interval in a dose- and concentration- dependent manner. Since the mean Cmax of azithromycin following a 500 mg IV dose given over 1 hr is higher than the mean Cmax of azithromycin following the administration of a 1500 mg oral dose, it is possible that QTc may be prolonged to a greater extent with IV azithromycin at close proximity to a one hour infusion of 500 mg.
Thus, plasma concentrations are higher following the intravenous regimen throughout the 24-hour interval. Tissue concentrations have not been obtained following intravenous infusions of azithromycin, but following oral administration in humans azithromycin has been shown to penetrate into tissues, including skin, lung, tonsil, and cervix. Tissue levels were determined following a single oral dose of 500 mg azithromycin in 7 gynecological patients.
Azithromycin pharmacokinetics were investigated in 42 adults 21 to 85 years of age with varying degrees of renal impairment. Following the oral administration of a single 1,000 mg dose of azithromycin, mean Cmax and AUC0-120 increased by 5.
Drug interaction studies were performed with oral azithromycin and other drugs likely to be co-administered. Azithromycin has been shown to be active against the following microorganisms, both in vitro and in clinical infections.
How should I take Zithromax Dispersible?
Azithromycin must be taken for the recommended duration of treatment, even if you are feeling better. This will reduce the chances of having remaining bacteria grow back. Finish all of this medication, even if you start to feel better. If you miss a dose, take it as soon as possible and continue on with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
What should I avoid while taking Zithromax Dispersible?
Get the most out of Medical News Today. If you would like to request a new activation link, click the button to request another. Food and Drug Administration has issued a warning stating that the commonly prescribed antibiotic azithromycin Zithromax or Zmax can cause irregular heart activity and result in a fatal heart rhythm. Zithromax is widely prescribed to treat a series of infections such as pneumonia, bronchitis, wheezing and COPD.
Patients with preexisting heart problems or low blood levels of potassium or magnesium are at a particularly high risk of developing this side effect of the medication. Some other alternative drugs such as fluoroquinolones also increase the risk of QT prolongation. A revised Warnings and Precautions box on the label of azithromycin will include information about the increased risk of QT interval prolongation and Torsades de Pointes - a rare heart rhythm problem.
What is hemoglobin, and what do high and low hemoglobin levels mean.
Zithromax Dispersible side effects
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Common Zithromax Dispersible ide effects may include:
As these patients with advanced HIV disease were taking multiple concomitant medications and experienced a variety of intercurrent illnesses, it was often difficult to attribute adverse reactions to study medication.
Sinusitis prednisone, ciprofloxacin, amoxicillin, azithromycin, Augmentin, More.
Chlamydia Infection amoxicillin, doxycycline, azithromycin, Levaquin, levofloxacin, erythromycin, More.
The individual MAC susceptibility results demonstrated that azithromycin MIC values could be 4 to 32-fold higher than clarithromycin MIC values.
Bacterial infections are often accompanied by symptoms such as pain, fever, redness or swelling of the skin or affected joint.
A bacterial infection usually does not clear up by itself. If you have an infection, it is important that it is treated to prevent complications.
More about Zithromax Dispersible
Other brands:Order light pack
Where can I get more information?
Know the medicines you take.
To provide azithromycin over a concentration range of 1.