Generic Name: Ziana
What is Ziana?
Adults, adolescents and children weighing at least 25 kg :The recommended dose of Ziagen is 600 mg daily. This may be administered as either 300 mg one tablet twice daily or 600 mg two tablets once daily see sections 4.
Children weighing less than 25 kg :Dosing according to weight bands is recommended for Ziagen tablets. This may be administered as either one 150 mg one half of a tablet taken in the morning and 300 mg one whole tablet taken in the evening, or 450 mg one and a half tablets taken once daily. This may be administered as either 150 mg one half of a tablet twice daily or 300 mg one whole tablet once daily.
Children less than three months of age: The clinical experience in children aged less than three months is limited and are insufficient to propose specific dosage recommendations see section 5. Patients changing from the twice daily dosing regimen to the once daily dosing regimen should take the recommended once daily dose as described above approximately 12 hours after the last twice daily dose, and then continue to take the recommended once daily dose as described above approximately every 24 hours.
When changing back to a twice daily regimen, patients should take the recommended twice daily dose approximately 24 hours after the last once daily dose. Special populationsNo dosage adjustment of Ziagen is necessary in patients with renal dysfunction.
How does abacavir work. How do people with HIV use abacavir. Restarting treatment Abacavir should never be restarted following a hypersensitivity reaction, as a fatal reaction could occur within hours.
Cardiovascular risk There are conflicting data from some studies about a link between heart attacks and the initial use of abacavir-containing products Ziagen and in Kivexa and Trizivir. Lactic acidosis and hepatic steatosis Two related conditions, lactic acidosis a buildup of lactic acid in the blood and hepatic steatosis excess fat in the liverhave occurred in some people who have used nucleoside analogues.
Lactic acidosis is rare less than one case per year for every thousand patients. Drug interactions Always consult your doctor and pharmacist about taking any other prescription or non-prescription medication, including herbs, supplements, and street drugs. If you must take a drug that has the potential to interact with your existing medications, your doctor can do the following: adjust your dose of either your antiretroviral drugs or other medications prescribe different antiretroviral drugs for you Drug interactions The following drugs interact or have the potential to interact with abacavir.
In men, the use of alcohol in combination with abacavir causes an increase of abacavir in the blood, which could cause an increase in toxic effects. This has not been studied in women. Abacavir can reduce levels of methadone in the blood, which might require an adjustment to your dose of methadone.
How should I take Ziana?
Company: ViiV Healthcare Viral infections Indications for ZIAGEN: HIV-1 infection. See Also: ZIAGEN ORAL SOLUTION Pharmacological Class: Nucleoside analogue reverse transcriptase inhibitor. Note: Register pregnant patients exposed to abacavir by calling 800 258-4263. All Rights Reserved This material may not be published, broadcast, rewritten or redistributed in any form without prior authorization. It is used with other medicines to treat HIV.
This medicine is not a cure for HIV. It will not stop the spread of HIV to others.
What should I avoid while taking Ziana?
Canada residents can call a provincial poison control center. Do not share this medication with others. Consult your doctor for more details. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule.
The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
Ziana side effects
HOW SUPPLIED Dosage Forms And Strengths ZIAGEN tablets contain 300 mg of abacavir as abacavir sulfate. They are packaged as follows: Bottles of 60 tablets NDC 49702-221-18. Unit dose blister packs of 60 tablets NDC 49702-221-44. It is packaged in plastic bottles as follows: Bottles of 240 mL NDC 49702-222-48 with child-resistant closure. Clinical Trials Experience In Adult Subjects Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.
Laboratory abnormalities in CNA3005 are listed in Table 5. Other Adverse Events In addition to adverse reactions and laboratory abnormalities reported in Tables 2, 3, 4, 5, and 6, other adverse reactions observed in the expanded access program were pancreatitis and increased GGT.
Common Ziana ide effects may include:
In some cases, these serious liver problems can lead to death.
Paediatric population:A randomised comparison of a regimen including once daily vs twice daily dosing of abacavir and lamivudine was undertaken within a randomised, multicentre, controlled study of HIV-infected, paediatric patients.
Treatment with ZIAGEN should be suspended in any patient who develops clinical or laboratory findings suggestive of lactic acidosis or pronounced hepatotoxicity which may include hepatomegaly and steatosis even in the absence of marked transaminase elevations.
Talk to your healthcare provider about how you can take part in this registry.
If you are hypersensitive to ZIAGEN you should return all of your unused ZIAGEN to your doctor or pharmacist for proper disposal. The usual dose of ZIAGEN in adults and in children weighing at least 25 kg is 600 mg a day. This can be taken as 300 mg one tablet twice a day, or 600 mg two tablets once a day, as advised by your doctor. The usual dose of ZIAGEN in children weighing at least 20 kg and less than 25 kg is 450 mg a day.
Where can I get more information?
Always consult your doctor and pharmacist about taking any other prescription or non-prescription medication, including herbs, supplements, and street drugs.
After 36 weeks on a regimen including twice daily abacavir and lamivudine, 669 eligible subjects were randomised to either continue twice daily dosing or switch to once daily abacavir and lamivudine for at least 96 weeks.