Generic Name: Ziana

What is Ziana?

Inclusion or absence of a drug label on the AIDSinfo site does not imply endorsement or lack thereof by AIDSinfo. Search Drugs FDA to access more information on abacavir, including additional drug labels and any generic equivalents. Lactic Acidosis and Severe Hepatomegaly with SteatosisLactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues and other antiretrovirals.

ZIAGEN tablets and oral solution, in combination with other antiretroviral agents, are indicated for the treatment of human immunodeficiency virus HIV-1 infection. Before prescribing ZIAGEN tablets, children should be assessed for the ability to swallow tablets. If a child is unable to reliably swallow ZIAGEN tablets, the oral solution formulation should be prescribed. ZIAGEN tablets contain 300 mg of abacavir as abacavir sulfate. The solution is a clear to opalescent, yellowish, strawberry-banana-flavored liquid.

Serious and sometimes fatal hypersensitivity reactions have occurred with ZIAGEN abacavir. In any patient treated with abacavir, the clinical diagnosis of hypersensitivity reaction must remain the basis of clinical decision making.

Due to the potential for severe, serious, and possibly fatal hypersensitivity reactions with ZIAGEN:Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues and other antiretrovirals.

A majority of these cases have been in women.

What else should I know about abacavir. ZiagenIs abacavir available as a generic drug. GENERIC AVAILABLE: No Do I need a prescription for abacavir. Yes What are the side effects of abacavir. The most common side effects are: nausea, vomiting, headache, fatigue, allergic reactions, diarrhea, loss of appetite, difficulty sleeping, muscle pain, increased triglyceride levels, rash, anxiety, depression, and fever. Quick GuideHIV AIDS Facts: Symptoms and Treatments Report Problems to the Food and Drug Administration You are encouraged to report negative side effects of prescription drugs to the FDA.

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Related Article HIV AIDS Facts: Symptoms and Treatments What is HIV AIDS human immunodeficiency virus-acquired immunodeficiency syndrome. Read more: HIV AIDS Facts: Symptoms and Treatments Complete List Top abacavir Related Articles abacavir, lamivudine, zidovudineAbacavir, lamivudine, zidovudine Trizivir is a combination drug prescribed to treat human immunodeficiency virus HIV infections.

Side effects, drug interactions, dosage, and pregnancy information should be reviewed prior to taking this medication. AIDS is the advanced stage of HIV infection. Symptoms and signs of AIDS include pneumonia due to Pneumocystis jiroveci, tuberculosis, toxoplasmosis, seizures, weakness, meningitis, yeast infection of the esophagus, and Kaposi's sarcoma.

How should I take Ziana?

Resistance In vitro resistance Abacavir-resistant isolates of HIV-1 have been selected in vitro and are associated with specific genotypic changes in the reverse transcriptase RT codon region codons M184V, K65R, L74V and Y115F. Additional information: The safety and efficacy of Ziagen in a number of different multidrug combination regimens is still not completely assessed particularly in combination with NNRTIs.

Paediatric population: A randomised comparison of a regimen including once daily vs twice daily dosing of abacavir and lamivudine was undertaken within a randomised, multicentre, controlled study of HIV-infected, paediatric patients.

Intracellular pharmacokinetics In a study of 20 HIV-infected patients receiving abacavir 300 mg twice daily, with only one 300 mg dose taken prior to the 24 hour sampling period, the geometric mean terminal carbovir-TP intracellular half-life at steady-state was 20.

Special patient populations Hepatic impairment Abacavir is metabolised primarily by the liver. Paediatric population According to clinical trials performed in children abacavir is rapidly and well absorbed from oral solution and tablet formulations administered to children.

What should I avoid while taking Ziana?

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed. Medications other than those listed above may interact with this medication.

Tell your doctor or prescriber about all prescription, over-the-counter non-prescriptionand herbal medications you are taking. Also tell them about any supplements you take. More severe side effects include hypersensitivity, liver damage, and lactic acidosis. Genetic testing can indicate whether a person is at higher risk of developing hypersensitivity.

Ziana side effects

After completion of Part A, subjects will be randomly assigned to cross-over treatment sequence Prurisol then Ziagen, or Ziagen then Prurisol. Five to 21 days later, each subject will receive the alternate study drug. Evaluable subjects in the PK population will be those who received both alternate treatments and for whom an adequate number of post-dose PK sample results are available. Three cohorts, each comprising 6 subjects, will be administered escalating single doses of Prurisol.

Part A consists of single doses of open-label Prurisol at doses of 50mg 1 tablet100mg 2 tablets and 200 mg 4 tablets administered to approximately equal numbers of male and female subjects. These treatments will be administered in 3 sequential cohorts with at least a 24 hour interval safety period between subjects in each of the 3 cohorts. To evaluate the safety and tolerability of Prurisol in healthy volunteers, completion of each dosing cohort will be followed by a 24-hour safety evaluation period before moving to a higher dose.

Adverse events from each dosed cohort will be reviewed prior to any dose escalation for next cohort.

Common Ziana ide effects may include:

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  • There are insufficient safety data to recommend the use of Ziagen in infants less than three months old.

The health care provider will also decide whether the child should take the tablet or liquid form of abacavir. If you take too much abacavir, contact your health care provider or local poison control center 1-800-222-1222 right away, or go to the nearest hospital emergency room. DailyMed is a federal website that includes the most recent drug labels submitted to FDA.

But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time.

More about Ziana

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Where can I get more information?

  • Absorption and Bioavailability: Following oral administration, abacavir is rapidly absorbed and extensively distributed.

  • Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.