Generic Name: Zestoretic
What is Zestoretic?
Medicines for diabetes insulin and oral antidiabetics such as sulphonylureas. Your dose of antidiabetic medicine may need to be changed when taking thiazide diuretics. Medicines to treat asthma. Medicines to treat nose or sinus congestion or other cold remedies including those you can buy in the pharmacy. Medicines for uneven heart beat problems such as procainamide. Gold injections such as sodium aurothiomalateusually used to treat rheumatoid arthritis.
Breast-feeding Tell your doctor if you are breast-feeding or about to start breast-feeding. Driving and using machines This medicine may cause occasional dizziness or tiredness which may have an effect on your ability to drive or use machines, especially at the start of treatment or when the dose is adjusted, or in combination with alcohol. If this happens to you, do not drive or use any tools or machines. You must wait to see how your medicine affects you before trying these activities.
This restriction typically limits the quantity of the drug that will be covered. ST Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription. This website also contains material copyrighted by 3rd parties. Share a CaseThis drug is available at a middle level co-pay. This drug is available at a higher level co-pay.
Prior Authorization Drugs that require prior authorization. Quantity Limits Drugs that have quantity limits associated with each prescription. Step Therapy Drugs that have step therapy associated with each prescription. Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
How should I take Zestoretic?
Thiazide diuretics such as hydrochlorothiazide have been shown to increase the urinary excretion of magnesium and decrease urinary calcium excretion. Thiazide diuretics may cause dilutional hyponatremia, particularly in elderly adults. Patients should be monitored for electrolyte imbalances.
Thiazide diuretics may precipitate azotemia in patients with renal disease. These effects, more commonly reported in patients with renal artery stenosis or those receiving concomitant diuretic therapy, are usually reversible and are not considered a reason to withhold therapy unless accompanied by hyperkalemia.
This effect rarely occurs in uncomplicated patients but more frequently in patients with renal impairment especially if they also have a collagen-vascular disease e.
What should I avoid while taking Zestoretic?
Patients receiving a diuretic during treatment with fluoxetine may be at greater risk of developing syndrome of inappropriate antidiuretic hormone secretion SIADH. Flurbiprofen: Nonsteroidal anti-inflammatory drugs NSAIDs may reduce the natriuretic effect of diuretics in some patients.
Fluvoxamine: Patients receiving a diuretic during treatment with fluvoxamine may be at greater risk of developing syndrome of inappropriate antidiuretic hormone secretion SIADH. Discontinuation of fluvoxamine should be considered in patients who develop symptomatic hyponatremia. Formoterol: Hypokalemia associated with thiazide diuretics can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded.
Zestoretic side effects
Closely monitor serum electrolytes during pentamidine therapy. Pentoxifylline: Pentoxifylline has been used concurrently with antihypertensive drugs beta blockers, diuretics without observed problems.
If indicated, dosage of the antihypertensive agents should be reduced. Perindopril: Patients with hyponatremia or hypovolemia are more susceptible to developing reversible renal insufficiency when given angiotensin converting enzyme ACE inhibitors and diuretics concomitantly. Phendimetrazine: Sympathomimetics can antagonize the effects of antihypertensives when administered concomitantly.
Phenelzine: Additive hypotensive effects may be seen when monoamine oxidase inhibitors MAOIs are combined with antihypertensives.
Common Zestoretic ide effects may include:
Periodic determination of serum electrolytes to detect possible electrolyte imbalance should be performed at appropriate intervals.
Careful monitoring of blood pressure is suggested during concurrent therapy of MAOIs with diuretics.
Rosiglitazone: Thiazide diuretics can decrease insulin sensitivity thereby leading to glucose intolerance and hyperglycemia.
In the same patients, these reactions were avoided when ACE inhibitors were temporarily withheld, but they reappeared upon inadvertent rechallenge.
Calcium salts Thiazide diuretics may increase serum calcium levels due to decreased excretion. Trimethoprim Concomitant administration of ACE inhibitors and thiazides with trimethoprim increases the risk of hyperkalaemia. Sotalol Thiazide induced hypokalaemia can increase the risk of sotalol induced arrhythmia.
Allopurinol Concomitant administration of ACE inhibitors and allopurinol increases the risk of renal damage and can lead to an increased risk of leucopoenia.
Where can I get more information?
Other antidiabetic drugs including insulin requirements in diabetic patients may be increased, decreased, or unchanged.
It may also have been difficult to swallow or breathe.