Generic Name: Zanaflex
What is Zanaflex?
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Tizanidine is a short-acting muscle relaxant that works by blocking certain nerve signals from the spine to the brain alpha adrenergic agonist. HOW TO USE: Take this medication by mouth as directed.
Coadministration may further increase the risk of QT prolongation and TdP. Ritonavir should be used cautiously and with close monitoring with tizanidine. Lorazepam: Concurrent use of tizanidine and CNS depressants like the benzodiazepines can cause additive CNS depression. Maprotiline: Maprotiline should be used cautiously and with close monitoring with tizanidine. Maprotiline has been reported to prolong the QT interval, particularly in overdose or with higher-dose prescription therapy elevated serum concentrations.
Cases of long QT syndrome and torsade de pointes TdP tachycardia have been described with maprotiline use, but rarely occur when the drug is used alone in normal prescribed doses and in the absence of other known risk factors for QT prolongation.
Limited data are available regarding the safety of maprotiline in combination with other QT-prolonging drugs. Meclizine: Concurrent use of tizanidine and CNS depressants like sedating h1-blockers can cause additive CNS depression.
Mefloquine: Mefloquine should be used cautiously and with close monitoring with tizanidine. There is evidence that the use of halofantrine after mefloquine causes a significant lengthening of the QTc interval. Mefloquine alone has not been reported to cause QT prolongation.
However, due to the lack of clinical data, mefloquine should be used with caution in patients receiving drugs that prolong the QT interval. Mepenzolate: CNS depression can be increased when mepenzolate is combined with other CNS depressants such as skeletal muscle relaxants. Meperidine: Concomitant use of opiate agonists with skeletal muscle relaxants may cause respiratory depression, hypotension, profound sedation, and death.
How should I take Zanaflex?
Does anyone on the board take Zanaflex for arthritis pain. I saw my Headache Specialist last week and explained that most of my pain is coming from my neck which is then triggering very painful migraine like pain on my right side only. He did a nerve block and I think it helped for a few hrs but that was it.
What should I avoid while taking Zanaflex?
The reduction in muscle tone was not associated with a reduction in muscle strength a desirable outcome but also did not lead to any consistent advantage of Zanaflex treated patients on measures of activities of daily living.
Figure 3 below shows a comparison of the mean change in muscle tone from baseline as measured by the Ashworth scale. Figure 3: Seven Week Study-Mean Change in Muscle Tone 0. Instruct patients to inform their physicians or pharmacists when they start or stop taking any medication because of the risks associated with interaction between Zanaflex and other medicines.
Tell patients to take Zanaflex exactly as prescribed consistently either with or without food and not to switch between tablets and capsules.
Zanaflex side effects
I Agree More info. BRAND NAMES: In the U. Zanaflex Description Tizanidine tye-ZAN-i-dine is used to help relax certain muscles in your body. It relieves the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis or certain injuries to the spine. Tizanidine does not cure these problems, but it may allow other treatment, such as physical therapy, to be more helpful in improving your condition. Tizanidine acts on the central nervous system CNS to produce its muscle relaxant effects.
Its actions on the CNS may also cause some of the medicine's side effects. This medicine is available only with your doctor's prescription, in the following dosage form: Oral Proper Use of This Medicine Take this medicine only as directed.
Common Zanaflex ide effects may include:
Which drugs or supplements interact with tizanidine-oral.
SWIM certainly wouldn't take it at higher than medicinal doses do to this limitation.
Acorda sued Apotex in October 2007 claiming that Apotex's generic product would infringe its patent, after the generic-drug maker filed an abbreviated new drug application with the U.
Examples include birth control pills, ciprofloxacin, fluvoxamine, among others.
Therefore, addition of tacrine to a stable tizanidine regimen may lead to tizanidine-related adverse effects such as oversedation, significant hypotension, or potential liver problems. Close monitoring for adverse effects is recommended during concomitant therapy Tacrolimus: Tacrolimus should be used cautiously and with close monitoring with tizanidine. Tacrolimus causes QT prolongation.
Tapentadol: Concomitant use of opiate agonists with skeletal muscle relaxants may cause respiratory depression, hypotension, profound sedation, and death. If tapentadol is initiated in a patient taking a skeletal muscle relaxant, a reduced initial dosage of tapentadol is recommended.
Where can I get more information?
Tizanidine administration may result in QT prolongation.
Because of potential drug interactions, Zanaflex is contraindicated in patients taking potent CYP1A2 inhibitors, such as fluvoxamine or ciprofloxacin.