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Currently available data are described in section 4. Due to the unknown clinical significance of higher exposure up to 10 fold to the two primary metabolites of linezolid in patients with severe renal insufficiency, linezolid should be used with special caution in these patients and only when the anticipated benefit is considered to outweigh the theoretical risk. The primary metabolites of linezolid are removed to some extent by haemodialysis, but the concentrations of these metabolites are still very considerably higher following dialysis than those observed in patients with normal renal function or mild to moderate renal insufficiency.

Therefore, linezolid should be used with special caution in patients with severe renal insufficiency who are undergoing dialysis and only when the anticipated benefit is considered to outweigh the theoretical risk. To date, there is no experience of linezolid administration to patients undergoing continuous ambulatory peritoneal dialysis CAPD or alternative treatments for renal failure other than haemodialysis.

Hepatic impairment:No dose adjustment is required. However, there are limited clinical data and it is recommended that linezolid should be used in such patients only when the anticipated benefit is considered to outweigh the theoretical risk see sections 4. Unless there are facilities available for close observation and monitoring of blood pressure, linezolid should not be administered to patients with the following underlying clinical conditions or on the following types of concomitant medications: - Patients with uncontrolled hypertension, phaeochromocytoma, carcinoid, thyrotoxicosis, bipolar depression, schizoaffective disorder, acute confusional states.

Animal data suggest that linezolid and its metabolites may pass into breast milk and, accordingly, breast-feeding should be discontinued prior to and throughout administration see section 4. In cases where the outcome is known, when linezolid was discontinued, the affected haematologic parameters have risen toward pretreatment levels.

Drug use investigation of Zyvox for patients with Methicillin-resistant Staphylococcus aureus MRSA infection disease. Zyvox Tablets 600mg, Zyvox Injection 600mg Dosage, Frequency: According to Japanese Package Insert, In adults, administer usually 600mg of linezolid twice daily q 12 hours for a total daily dose of 1200 mg. Duration: According to the protocol of A5951142, the duration of the investigation for findings regarding safety and efficacy of a patient is from the first drug administration to the 8 weeks after the first administration.

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All observed or volunteered adverse events and the investigator's opinion of the causal relationship to the study treatment were reported. Adverse Drug Reactions were evaluated in company with the causal relationship to the investigational product. Number of participants with or without Renal dysfunctions with adverse drug reaction to determine whether with or without is significant risk factor. Number of participants with Duration of drug administration as over 15 days or less than 15 days with adverse drug reaction to determine whether over 15 days or less than 15 days is significant risk factor.

Number of participants Route of administration as by oral,injection or oral from injection with adverse drug reaction to determine whether oral, injection or switch is significant risk factor. Number of participants Weight as over 40kg or less than 40kg with adverse drug reaction to determine whether over 40kg or less than 40kg Weight is significant risk factor.

Number of participants with or without Concomitant drugs with adverse drug reaction to determine whether with or without is significant risk factor.

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Injection is supplied in single-use, ready-to-use infusion bags. Injection should be administered by intravenous infusion over a period of 30 to 120 minutes. Do not use this intravenous infusion bag in series connections.

Additives should not be introduced into this solution. Injection is to be given concomitantly with another drug, each drug should be given separately in accordance with the recommended dosage and route of administration for each product.

If the same intravenous line is used for sequential infusion of several drugs, the line should be flushed before and after infusion of ZYVOX I. Injection with an infusion solution compatible with ZYVOX I.

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The following recommendations for duration of therapy reflect those used in the clinical trials. Shorter treatment regimens may be suitable for some types of infection but have not been evaluated in clinical trials. The maximum treatment duration is 28 days. The safety and effectiveness of linezolid when administered for periods longer than 28 days have not been established. No increase in the recommended dosage or duration of treatment is required for infections associated with concurrent bacteraemia.

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  • This article contains incorrect information.

  • Linezolid also belongs to a class of drugs known as MAO inhibitors.

Do not use linezolid if you have used an MAO inhibitor such as furazolidone Furoxoneisocarboxazid Marplanphenelzine Nardilrasagiline Azilectselegiline Eldepryl, Emsam, Zelaparor tranylcypromine Parnate in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Many drugs can interact with linezolid.

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