Generic Name: Vepesid
What is Vepesid?
VePesid etoposide should be considered a potential carcinogen in humans. The occurrence of acute leukemia with or without a preleukemic phase has been reported in rare instances in patients treated with etoposide alone or in association with other neoplastic agents. The risk of development of a preleukemic or leukemic syndrome is unclear.
Carcinogenicity tests with VePesid etoposide have not been conducted in laboratory animals. In all instances where the use of VePesid etoposide is considered for chemotherapy, the physician must evaluate the need and usefulness of the drug against the risk of adverse reactions.
Most such adverse reactions are reversible if detected early. If severe reactions occur, the drug should be reduced in dosage or discontinued and appropriate corrective measures should be taken according to the clinical judgment of the physician. Reinstitution of VePesid etoposide therapy should be carried out with caution, and with adequate consideration of the further need for the drug and alertness as to possible recurrence of toxicity. Treatment of Swiss-Albino mice with 1.
Maternal weight gain was not affected.
Your doctor may decide to delay your treatment until the infection has gone. Do not take VEPESID if you are receiving radiation therapy or any other medicine, which lowers your immune system. Do not take VEPESID if you are pregnant or intend to become pregnant. Like most medicines used to treat cancer, VEPESID is not recommended for use during pregnancy, unless you and your doctor have discussed the risks and benefits involved.
You should use some kind of birth control while you are having VEPESID and for at least 12 weeks after you stop using it. VEPESID may cause birth defects if either the male or female is using it at the time of conception. Do not breastfeed while having VEPESID, unless you have discussed it with your doctor.
It is not known whether VEPESID passes into breast milk. Therefore there is a possibility that the breast-fed baby may be affected. If you have not told your doctor about any of the above, tell them before you start VEPESID.
If you have not told your doctor about any of the above, tell them before you start taking VEPESID.
How should I take Vepesid?
Given its mechanism of action, it should be considered a possible carcinogen in humans. See also hematological toxicity Acute leukemiawith or without a preleukemic phase has been reported in patients treated with etoposide in association with other antineoplastic drugs.
Nursing Mothers It is not known whether this drug is excreted in human milk Paediatric Use Safety and effectiveness in paediatric patientshave not been established. VEPESID injection contains polysorbate 80. In premature infants a life threatening syndrome consisting of liver and renal failure, pulmonary deterioration, thrombocytopenia and ascites has been associated with an injectable Vitamin E product containing polysorbate 80.
Drug interactions High dose cyclosporine co-administered with etoposide led to a increase in etoposide exposure AUC with a decrease in total body clearance of etoposide compared to etoposide alone. No proven antidotes have been established for VEPESID overdosage.
What should I avoid while taking Vepesid?
The basic usage of this drug is for the treatment of lung cancer, testicular cancer, lymphoma. Ewing's sarcoma, glioblastoma multiforme and non lymphocytic leukaemia in the form of chemotherapy. Vepesid is also advantangeous in regimen condition prior to bone marrow or blood cell stem transplant.
Vepesid along with certain other drugs is also recommended. Administration Vepesid is given in the form of capsule or sometimes intravenously. When given through veins intravenouslythe process duration should be of 30 to 60 minutes as it can lower the blood pressure. So it become necessary to keep on checking the blood pressure during infusion. Pharmacology Several studies conducted to analyze the effect of vepesid have revealed that this drug initially causes arrest of metaphase, but with the due course of time the effect is replaced by the interference of cell cycle progression prior to the cell entering mitosis.
Vepesid side effects
The table below has been updated with the new status information. For further information please contact the product sponsors. Update 14 February 2017 Consumers and health professionals are advised that there are current shortages of Etopophos etoposide 1 g as phosphate and Etopophos etoposide phosphate 113.
The shortage of Vepesid etoposide 100 mg capsule blister pack has been resolved. The information and table below have been updated with new information.
Common Vepesid ide effects may include:
No delayed hypotension has been noted.
Etoposide may also be used for purposes not listed in this medication guide.
If it is near the time of the next dose, the missed one should be skip and the usual dosing schedule should be resume.
Any unused medication should be returned to your pharmacy or treatment clinic for proper disposal.
Etoposide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: nauseavomitingsores in the mouth and throatstomach paindiarrheaconstipationloss of appetite or weightunusual tiredness or weaknesspale skinfaintingdizzinesshair losspain, burning, or tingling in the hands or feeteye painvision problemsSome side effects can be serious.
If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, stop taking etoposide and call your doctor immediately or get emergency medical treatment: rashhivesitchingdifficulty breathing or swallowingfast, irregular, or pounding heartbeatseizuresyellowing of the skin or eyesEtopside may increase the risk that you will develop other cancers.
Talk to your doctor about the risks of taking this medication. Etoposide may cause other side effects.
Where can I get more information?
Be sure to mention any of the following: cisplatin Platinolcyclosporine Gengraf, Neoral, Sandimmune.
I have been prescribed it and am just seeing if anyone else is and how they take it.