Generic Name: Suprax
What is Suprax?
Increased prothrombin time, with or without clinical bleeding, has been reported when cefixime is administered concomitantly. A false-positive reaction for ketones in the urine may occur with tests using nitroprusside but not with those using nitroferricyanide.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088. Before therapy with Suprax is instituted, careful inquiry should be made to determine whether the patient has had previous hypersensitivity reactions to cephalosporins, penicillins, or other drugs.
If an allergic reaction to Suprax occurs, discontinue the drug. Clostridium difficile associated diarrhea CDAD has been reported with use of nearly all antibacterial agents, including Suprax, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. Hypertoxin producing isolates of C. CDAD must be considered in all patients who present with diarrhea following antibiotic use. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents.
Cefixime is contraindicated in patients with cephalosporin hypersensitivity or cephamycin hypersensitivity. Cefixime should be used cautiously in patients with hypersensitivity to penicillin. The structural similarity between cefixime and penicillin means that cross-reactivity can occur. Penicillins can cause a variety of hypersensitivity reactions ranging from mild rash to fatal anaphylaxis.
Patients who have experienced severe penicillin hypersensitivity should not receive cefixime. Additionally, cefixime should be administered cautiously to any patient who has demonstrated any form of allergy, particularly to drugs. Use cefixime with caution in patients with renal impairment, including renal failure, since the drug is eliminated via renal mechanisms. This includes patients undergoing continuous ambulatory peritoneal dialysis CAPD and hemodialysis.
Dosages should be adjusted. Dialysis patients should be carefully monitored. Almost all antibacterial agents have been associated with pseudomembranous colitis antibiotic-associated colitis which may range in severity from mild to life-threatening. In the colon, overgrowth of Clostridia may exist when normal flora is altered subsequent to antibacterial administration.
The toxin produced by Clostridium difficile is a primary cause of pseudomembranous colitis. It is known that systemic use of antibiotics predisposes patients to development of pseudomembranous colitis. Consideration should be given to the diagnosis of pseudomembranous colitis in patients presenting with diarrhea following antibacterial administration.
How should I take Suprax?
Some people who are allergic to penicillin antibiotics may not be able to take cefixime, so make sure your doctor knows if you have ever had an allergic reaction to any other antibiotic. Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken.
For these reasons, before you start taking cefixime it is important that your doctor knows:Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with cefixime. You will find a full list in the manufacturer's information leaflet supplied with your medicine.
The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Important: if you develop an itchy rash, swollen face or mouth, or have difficulty breathing, these can be signs that you are allergic to the antibiotic.
What should I avoid while taking Suprax?
Many people using Suprax Cefixime 400mg do not have serious side effects. Suprax Cefixime 400mg may rarely cause a severe intestinal condition Clostridium difficile-associated diarrhea due to a resistant bacteria. Use of Suprax Cefixime 400mg for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection oral or vaginal fungal infection.
A very serious allergic reaction to Suprax Cefixime 400mg is rare. Click here to view a more detailed list of Suprax side effects.
Suprax side effects
The product should be discontinued if severe diarrhoea develops. Renal function should be monitored with particular care when combining cefixime with aminoglycoside antibiotic, polymyxin B, colistin or high-dosed loop diuretics e.
This is applied especially to patients with pre-existing renal impairment. Use of the product should be cautious in patients allergic to penicillins. Bleeding tendency due to Vitamin K deficiency may occur in the elderly. Cefixime has high affinity for penicillin binding proteins PBP 1 1a, 1b and 1c and 3 and prevents cross-linking reaction. Cefixime has broad spectrum activity against Gram-positive and Gram-negative bacteria. Sensitivity will vary according to area, and local prescribing guidelines should always be consulted.
Common Suprax ide effects may include:
Seek immediate medical attention if you experience any allergic symptoms like rash, itching, nausea or vomiting, swelling of lips, hands, and feet.
Monitor patients for signs and symptoms of bleeding.
PolyMedix Expands Research Science Advisory BoardIn 2004, Lupin introduced its first brand to the US: Suprax, a cefixime product that had previously been marketed by Wyeth until March 2003.
Discuss the risks and benefits with your doctor. It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding. Drug interactions may change how your medications work or increase your risk for serious side effects.
Where can I get more information?
Generally, Cefixime does not cause side effects.
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