Generic Name: Strattera
What is Strattera?
Atomoxetine has minimal affinity for other noradrenergic receptors or for other neurotransmitter transporters or receptors. Atomoxetine has two major oxidative metabolites: 4-hydroxyatomoxetine and N-desmethylatomoxetine. N-desmethylatomoxetine has substantially less pharmacological activity compared with atomoxetine.
It circulates in plasma at lower concentrations in extensive metabolisers and at comparable concentrations to the parent drug in poor metabolisers at steady-state. Atomoxetine is not a psychostimulant and is not an amphetamine derivative.
In a randomised, double-blind, placebo-controlled, abuse-potential study in adults comparing effects of atomoxetine and placebo, atomoxetine was not associated with a pattern of response that suggested stimulant or euphoriant properties. Clinical efficacy and safetySTRATTERA has been studied in trials in over 5000 children and adolescents with ADHD. The acute efficacy of STRATTERA in the treatment of ADHD was initially established in six randomised, double-blind, placebo-controlled trials of six to nine weeks duration.
Signs and symptoms of ADHD were evaluated by a comparison of mean change from baseline to endpoint for STRATTERA-treated and placebo-treated patients.
In each of the six trials, atomoxetine was statistically significantly superior to placebo in reducing ADHD signs and symptoms.
STRATTERA may not be right for you or your child. STRATTERA and some medicines may interact with each other and cause serious side effects. Your doctor will decide whether STRATTERA can be taken with other medicines.
Know the medicines that you or your child takes. Keep a list of your medicines with you to show your doctor and pharmacist. This is not a complete list of possible side effects. Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use STRATTERA for a condition for which it was not prescribed. Do not give STRATTERA toother people, even if they have the same condition. It may harm them. This Medication Guide summarizes the most important information about STRATTERA.
If you would like more information, talk with your doctor. You can ask your doctor or pharmacist forinformation about STRATTERA that was written for healthcare professionals. For more information about STRATTERA call 1-800-Lilly-Rx 1-800-545-5979 or visit www.
How should I take Strattera?
Marketed by: Lilly USA, LLC Indianapolis, IN 46285, USA. Child And Adolescent Clinical Trials Reasons For Discontinuation Of Treatment Due To Adverse Reactions In Child And Adolescent Clinical Trials In acute child and adolescent placebo-controlled trials, 3. Adult Clinical Trials Reasons For Discontinuation Of Treatment Due To Adverse Reactions In Acute Adult Placebo-Controlled Trials In the acute adult placebo-controlled trials, 11. Male And Female Sexual Dysfunction Atomoxetine appears to impair sexual function in some patients.
Antihypertensive Drugs And Pressor Agents Because of possible effects on blood pressure, STRATTERA should be used cautiously with antihypertensive drugs and pressor agents e. Albuterol STRATTERA should be administered with caution to patients being treated with systemically-administered oral or intravenous albuterol or other beta2 agonists because the action of albuterol on the cardiovascular system can be potentiated resulting in increases in heart rate and blood pressure.
Effect Of Atomoxetine On P450 Enzymes Atomoxetine did not cause clinically important inhibition or induction of cytochrome P450 enzymes, including CYP1A2, CYP3A, CYP2D6, and CYP2C9.
Alcohol Consumption of ethanol with STRATTERA did not change the intoxicating effects of ethanol.
What should I avoid while taking Strattera?
Severe cerebrovascular disorders may include cerebral aneurysm or stroke. Atomoxetine should not be used in patients with pheochromocytoma or a history of pheochromocytoma see section 4. In double-blind clinical trials, suicide-related behaviours were uncommon, but more frequently observed among children and adolescents treated with atomoxetine compared to those treated with placebo, where there were no events.
In adult double-blind clinical trials there was no difference in the frequency of suicide-related behaviour between atomoxetine and placebo. Patients who are being treated for ADHD should be carefully monitored for the appearance or worsening of suicide-related behaviour.
Strattera side effects
This leaflet answers some common questions about STRATTERA. More recent information on this medicine may be available. Make sure you speak to your pharmacist or doctor to obtain the most up to date information on this medicine. You can also download the most up to date leaflet from www.
The updated leaflet may contain important information about STRATTERA and its use that you should be aware of. All medicines have risks and benefits. Your doctor has weighed the risks of you taking STRATTERA against the benefits it may have for you.
Common Strattera ide effects may include:
VA I just started taking Strattera.
STRATTERA did not worsen anxiety in these patients as determined by the Liebowitz Social Anxiety Scale LSAS.
W hether any of the symptoms described above represent such a conversion is unknown.
How long one is supposed to use Strattera to notice its effect.
N-desmethylatomoxetine has substantially less pharmacological activity compared with atomoxetine. It circulates in plasma at lower concentrations in extensive metabolisers and at comparable concentrations to the parent drug in poor metabolisers at steady-state. Atomoxetine is not a psychostimulant and is not an amphetamine derivative.
Where can I get more information?
When remedial measures alone are insufficient, the decision to prescribe drug treatment medication will depend upon the physician's assessment of the chronicity and severity of the patient's symptoms.
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