Generic Name: Starlix

What is Starlix?

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GU: renal toxicity with long-term use in patients in whom renal prostaglandins have a compensatory role in maintenance of renal perfusionrenal papillary necrosisGI: nausea, diarrhea, constipation, heartburn, abdominal pain, stomatitis, GI bleedingSkin: rash, pruritus, skin eruptions, sweating, photosensitivity, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysisDrug-drug.

Acetaminophen chronic usecyclosporine: increased risk of adverse renal effectsAntihypertensives, cefamandole, cefoperazone, cefotetan, diuretics, eptifibatide: decreased responseClopidogrel, plicamycin, ticlopidine, valproic acid: increased risk of bleeding Insulin, oral hypoglycemics: increased risk of hypoglycemiaDrug-diagnostic tests.

Alanine amino-transferase, alkaline phosphatase, aspartate aminotransferase, blood urea nitrogen, creatinine, lactate dehydroge-nase, potassium: increased levelsCreatinine clearance, glucose, hematocrit, hemoglobin, leukocytes, platelets: decreased valuesDrug-herbs.

Anise, arnica, chamomile, clove, dong quai, fenugreek, feverfew, garlic, ginger, ginkgo, ginseng, licorice: increased anticoagulant effect, increased risk of bleeding In long-term use, assess CBC with white cell differential and coagulation studies, and monitor for visual and hearing impairment and renal toxicity.

Instruct patient how to recognize and immediately report signs and symptoms of renal toxicity and serious skin manifestations. Pharmacologic class: Selective 5-hydroxytryptamine1 5-HT1 agonistBinds with specific 5-HT1 receptors in intracranial blood vessels and sensory trigeminal nerves, leading to vasoconstriction and migraine reliefAdults: 1 or 2.

CNS: dizziness, drowsiness, malaise, fatigue, paresthesia, cerebral hemorrhage, subarachnoid hemorrhage, stroke, other cerebrovascular eventsCV: significant blood pressure elevation including hypertensivecrisis rarecoronary artery vasospasm, myocardial infarction, ventricular fibrillation or tachycardiaOther: pain or pressure sensation in throat or neck, peripheral vascular ischemia, serotonin syndrome, hypersensitivity including anaphylaxis or anaphylactoid reactionsDrug-drug.

Ergot-type compounds dihydroergotamine, methysergide : prolonged vasospastic reactionMAO inhibitors: increased systemic exposure to naratriptan, increased risk of adverse reactionsSelective serotonin reuptake inhibitors: weakness, hyperreflexia, incoordination Sibutramine: serotonin syndromeDrug-herbs.

Drug increases risk of progressive multifocal leukoencephalopathy PMLan opportunistic viral infection of the brain that usually leads to death or severe disability. Disruption of these molecular interactions prevents transmigration of leukocytes across the endothelium into inflamed parenchymal tissue.

If you need more information about your medical condition or your treatment, read the Package Leaflet also part of the EPAR or contact your doctor or pharmacist. If you want more information on the basis of the CHMP recommendations, read the Scientific Discussion also part of the EPAR. Starlix is a medicine containing the active substance nateglinide. It is available as pink, round 60 mgyellow, oval 120 mg and red, oval 180 mg tablets.

Starlix is used in patients who have non insulin-dependent diabetes type 2 diabetes. Starlix is used together with metformin another antidiabetes medicine to lower blood glucose sugar in patients whose diabetes cannot be controlled by metformin alone. Starlix is given within one to 30 minutes before breakfast, lunch and dinner and the dose is adjusted to give the best control. A doctor should regularly test the patient's blood glucose to find the lowest effective dose.

The recommended starting dose is 60 mg three times a day before meals. This dose may need to be increased to a daily dose of 120 mg three times a day after one or two weeks. The maximum total daily dose is 180 mg three times a day.

How should I take Starlix?

Metabolism Nateglinide is metabolized by the mixed-function oxidase system prior to elimination. Excretion Nateglinide and its metabolites are rapidly and completely eliminated following oral administration. Glyburide In a randomized, multiple-dose crossover study, patients with Type 2 diabetes were administered 120 mg nateglinide three times a day before meals for 1 day in combination with glyburide 10 mg daily.

Metformin When nateglinide 120 mg three times daily before meals was administered in combination with metformin 500 mg three times daily to patients with Type 2 diabetes, there were no clinically relevant changes in the pharmacokinetics of either agent. Digoxin When nateglinide 120 mg before meals was administered in combination with a single 1mg dose of digoxin to healthy volunteers, there were no clinically relevant changes in the pharmacokinetics of either agent.

What should I avoid while taking Starlix?

Geriatric Use 436 patients 65 years and older, and 80 patients 75 years and older were exposed to STARLIX in clinical studies. Hepatic Impairment No dose adjustment is recommended for patients with mild hepatic impairment. Hypoglycemia All oral blood glucose lowering drugs that are absorbed systemically are capable of producing hypoglycemia.

Hepatic Impairment Nateglinide should be used with caution in patients with moderate-to-severe liver disease because such patients have not been studied. Loss Of Glycemic Control Transient loss of glycemic control may occur with fever, infection, trauma, or surgery. Geriatric Use No differences were observed in safety or efficacy of nateglinide between patients age 65 and over, and those under age 65.

This condition should be treated with insulin.

Starlix side effects

Swallow the tablets whole with a glass of water before the meal. How long to take Starlix Take Starlix daily until your doctor tells you to stop. If you take more Starlix than you should If you have accidentally taken too many tablets, talk to a doctor straight away. If you forget to take Starlix If you forget to take a tablet simply take the next one before your next meal. What are possible side effects.

These includesweating,dizziness,shaking,weakness,hunger,feeling your heart beating fast,tiredness,feeling sick nausea.

Send Home Tools Medications Lexicon Medications Lexicon Search : Submit A Brand Name Starlix Common Name nateglinide The content of this page: How does this medication work. How should I use this medication.

Common Starlix ide effects may include:

  • Based on the experience with nateglinide and with other hypoglycaemic agents, the following adverse reactions have been seen.

  • There are three types of insulin.

  • This is due to the fact that online stores have different prices for this product as each store is at the liberty of selling the product at a price that appeals to the store owner.

  • Alanine amino-transferase, alkaline phosphatase, amylase, aspartate aminotransferase, creatine kinase, gamma-glutamyl transpeptidase, lactic dehydrogenase lipids, uric acids: increased levels Blood glucose: increased or decreased level Watch for signs and symptoms of depression and suicidal ideation.

Nateglinide is used alone or with other medications to control high blood sugar along with a proper diet and exercise program. It is used in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems.

Where can I get more information?

  • Watch carefully for signs of low blood sugar, especiallyif you have exercised more strenuously than usual.

  • It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine.