Generic Name: Starlix
What is Starlix?
Dosierung, Anwendungsgebiete, Hinweise zur Einnahme, Wechselwirkungen. Starlix Tablet Nateglinide Side Effects, Interactions Azienda multinazionale svizzera che opera nel settore farmaceutico.
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If you have Type 2 diabetes, your doctor may prescribe Starlix for treatment or its generic form, Nateglinide. Starlix is a meglitinide analog medication that works to lower blood glucose levels. Starlix works by triggering the production of insulin in the pancreas. Insulin is a hormone used by cells in the body to absorb sugar from the blood to use for energy.
Before beginning treatment with Starlix, it is important to talk to your doctor about any allergies or medical conditions you may have, and about any medications and supplements you are currently taking. Starlix is available in the form of a pill. To use Starlix, take one pill up to half an hour before you eat each meal. If you skip or miss a meal, do not take Starlix. If you add a meal, then take an extra dose of Starlix.
How should I take Starlix?
The safety and effectiveness of STARLIX have not been established in pediatric patients. STARLIX nateglinide is an oral blood glucose-lowering drug of the glinide class. Inactive Ingredients: colloidal silicon dioxide, croscarmellose sodium, hydroxypropyl methylcellulose, iron oxides red or yellowlactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, povidone, talc, and titanium dioxide.
In vitro assessment of drug interactionsSTARLIX is a potential inhibitor of the CYP2C9 isoenzyme in vivo as indicated by its ability to inhibit the in vitro metabolism of tolbutamide.
In vivo assessment of drug interactionsThe effect of coadministered drugs on the pharmacokinetics of nateglinide and the effect of nateglinide on pharmacokinetics of coadministered drugs are shown in Tables 3 and 4. Carcinogenicity: Nateglinide did not increase tumors in two year carcinogenicity studies conducted in mice and rats. Mutagenesis: Nateglinide was not genotoxic in the in vitro Ames test, mouse lymphoma assay, chromosome aberration assay or in the in vivo mouse micronucleus test.
In a 24-week, double-blind, placebo-controlled study, patients with type 2 diabetes were randomized to receive either STARLIX 60 mg or 120 mg three times daily before meals or placebo.
What should I avoid while taking Starlix?
Beta-adrenergic blockers, MAO inhibitors, nonsteroidal antiinflammatory drugs, salicylates: increased hypoglycemic effectCorticosteroids, sympathomimetics, thiazides, thyroid products: reduced hypoglycemic effectDrug-diagnostic tests. Adverse reactionsCNS: headache, fatigue, dizziness, insomniaCV: bradycardiaGI: nausea, diarrheaRespiratory: dyspneaSkin: rashOther: chest pain, peripheral edemaInteractionsDrug-drug.
Antiarrhythmics such as disopyramidemyocardial depressants or AV conduction inhibitors such as cardiac glycosides and certain calcium antagonists : increased risk of slowed AV conduction and bradycardiaCimetidine: increased d-nebivolol active isomer blood levelCYP2D6 inhibitors such as fluoxetine, paroxetine, propafenone, quinidine : increased d-nebivolol blood levelOther beta-adrenergic blockers: excessive reduction of sympathetic activity Sildenafil: decreased effect of sildenafilDrug-diagnostic tests.
Blood urea nitrogen, triglycerides, uric acid: increased levelsCholesterol, high-density lipoproteins, platelet count: decreasedPatient monitoring Be aware that beta blockade may further depress myocardial contractility and trigger more severe heart failure in patients with compensated CHF.
Don't give concurrently with cisapride, pimozide, carbamazepine, or triazolam. Don't give within 14 days of MAO inhibitors.
Starlix side effects
If blockage occurs, calcium salts may reverse these phenomena, but patient may need mechanical respiratory assistance. Avoid concurrent or sequential systemic, oral, or topical use of other aminoglycosides or neurotoxic drugs, as toxicity may be additive. Avoid giving drug concurrently with potent diuretics, as some diuretics are ototoxic. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only.
This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. Monitor patient and withhold drug immediately at first sign or symptom suggestive of PML.
Adverse reactionsCNS: dizziness, drowsiness, headache, vertigo, light-headednessCV: palpitations, tachycardia, hypertensionGU: renal toxicity with long-term use in patients in whom renal prostaglandins have a compensatory role in maintenance of renal perfusionrenal papillary necrosisEENT: visual disturbances, tinnitus, auditory disturbancesGI: nausea, diarrhea, constipation, heartburn, abdominal pain, stomatitis, GI bleedingSkin: rash, pruritus, skin eruptions, sweating, photosensitivity, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysisOther: thirst, edema, allergic reactions including anaphylaxisInteractionsDrug-drug.
Common Starlix ide effects may include:
Nateglinide should be administered prior to meals to reduce the risk of hypoglycemia.
There have been no instances of overdose with STARLIX in clinical trials.
The major metabolites are less potent antidiabetic agents than nateglinide.
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I think the same reason that docs don't like other sulfonyurea drugs would be relevant for this. I think it may burn out exhisting beta cells faster. Now for you it might be great, my question would be how is your control on MDI and why does your doc want to take you off it. I had very high bs while I was on it but my control is much different than many type 2s without insulin I am always high.
Where can I get more information?
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Starlix is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care.