Generic Name: Sporanox
What is Sporanox?
Effective contraception should be continued until the menstrual period following the end of Sporanox Capsules therapy. Therefore, caution should be exercised when co-administering itraconazole and calcium channel blockers see section 4.
It is recommended that liver function monitoring be done in patients with pre-existing hepatic function abnormalities or those who have experienced liver toxicity with other medications. Paediatrics Clinical data on the use of Sporanox Capsules in paediatric patients is limited. Several of these reports included concurrent administration of quinidine which is contraindicated see section 4. Patients with immediately life-threatening systemic fungal infectionsDue to the pharmacokinetic properties See section 5.
Patients with AIDSIn patients with AIDS having received treatment for a systemic fungal infection such as sporotrichosis, blastomycosis, histoplasmosis or cryptococcosis meningeal or non-meningeal and who are considered at risk for relapse, the treating physician should evaluate the need for a maintenance treatment.
NeuropathyIf neuropathy occurs which may be attributable to Sporanox Capsules, the treatment should be discontinued. Cross-resistanceIn systemic candidosis, if fluconazole-resistant strains of Candida species are suspected, it cannot be assumed that these are sensitive to itraconazole, hence their sensitivity should be tested before the start of Sporanox therapy.
Drugs that may decrease itraconazole plasma concentrationsDrugs that reduce the gastric acidity e. It is recommended that these drugs be used with caution when coadministered with itraconazole capsules:It is recommended that itraconazole be administered with an acidic beverage such as non-diet cola upon co-treatment with drugs reducing gastric acidity. Coadministration of itraconazole with potent enzyme inducers of CYP3A4 may decrease the bioavailability of itraconazole and hydroxy-itraconazole to such an extent that efficacy may be largely reduced.
It contains 7 pouches-one for each day of treatment. Inside each pouch is a card containing 4 capsules. Looking at the back of the card, fold it back along the dashed line and peel away the backing so that you can remove 2 capsules.
Week 3 Week 4 The most common side effects include: headache, and digestive system problems such as nausea, and abdominal pain. Very rarely, an oversensitivity to sunlight, a tingling sensation in the limbs or a severe skin disorder can occur.
Call your doctor right away if you develop tingling or numbness in your extremities hands or feetif your vision gets blurry or you see double, if you hear a ringing in your ears, if you lose the ability to control your urine or urinate much more than usual.
Additional possible side effects include upset stomach, vomiting, constipation, fever, inflammation of the pancreas, menstrual disorder, erectile dysfunction, dizziness, muscle pain, painful joints, unpleasant taste, or hair loss. Your doctor or pharmacist can give you a more complete list.
Medicines are sometimes prescribed for conditions that are not mentioned in patient information leaflets. It may harm them. If you would like more information, talk with your doctor. This patient information has been approved by the U.
How should I take Sporanox?
Advise patients that if they experience these events, they should not drive or use machines. HIV-Infected Patients Because hypochlorhydria has been reported in HIV-infected individuals, the absorption of itraconazole in these patients may be decreased.
Renal Impairment Limited data are available on the use of oral itraconazole in patients with renal impairment. Hepatic Impairment Limited data are available on the use of oral itraconazole in patients with hepatic impairment. Absorption Itraconazole is rapidly absorbed after oral administration.
What should I avoid while taking Sporanox?
Examples are: ritonavir, indinavir, clarithromycin and erythromycin. Effect of itraconazole on the metabolism of other drugs: 2. After stopping treatment, itraconazole plasma levels decline gradually, depending on the dose and duration of treatment.
This should be taken into account when the inhibitory effect of itraconazole on comedicated drugs is considered. Examples are: Drugs which should not be used during treatment with itraconazole: Terfenadine, astemizole, mizolastine, cisapride, triazolam, oral midazolam, dofetilide, quinidine, pimozide, CYP3A4 metabolised HMG-CoA reductase inhibitors such as simvastatin and lovastatin.
Sporanox side effects
Itraconazole is an antifungal medication. Itraconazole is used to treat infections caused by fungus, which can invade any part of the body including the lungs, mouth or throat, toenails, or fingernails. Itraconazole may also be used for purposes not listed in this medication guide.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You should not take this medication if you are allergic to itraconazole or similar medications such as fluconazole or ketoconazole, if you have ever had congestive heart failure, or if you are pregnant or may become pregnant during treatment.
Common Sporanox ide effects may include:
It is recommended that these drugs be used with caution when coadministered with itraconazole capsules: It is recommended that itraconazole be administered with an acidic beverage such as non-diet cola upon co-treatment with drugs reducing gastric acidity.
Many drugs can interact with itraconazole, and some drugs should not be used together.
For the treatment of blastomycosis and histoplasmosis the recommended dose is 200mg once daily but if there is no improvement then the dose can be increased upto 400mg.
Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here.
Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one. The Sporanox PulsePak has a special dosing schedule that includes not taking the medicine for several days in a row.
Follow all dosing instructions carefully.
Where can I get more information?
Breast-feeding: This medication passes into breast milk.