Generic Name: Sinemet

What is Sinemet?

Therefore patients and providers are advised to monitor for melanomas on a regular basis when using 'Sinemet' for any indication. Laboratory TestsCommonly, levels of blood urea nitrogen, creatinine, and uric acid are lower during administration of 'Sinemet' than with levodopa.

Transient abnormalities include elevated levels of blood urea, AST SGOTALT SGPTLDH, bilirubin, and alkaline phosphatase. Decreased haemoglobin, haematocrit, elevated serum glucose and white blood cells, bacteria and blood in the urine have been reported. Positive Coombs' tests have been reported, both with 'Sinemet' and levodopa alone.

The use of glucose oxidase methods may give false negative results for glycosuria. Antihypertensive agentsPostural hypotension can occur when 'Sinemet' is added to the treatment of patients already receiving antihypertensive drugs. Dosage adjustment of the antihypertensive agent may be required.

Other drugsTo date there has been no indication of interactions that would preclude concurrent use of standard antiparkinsonian drugs. The beneficial effects of levodopa in Parkinson's disease have been reported to be reversed by phenytoin and papaverine.

In addition, certain medications used to treat psychosis may exacerbate the symptoms of Parkinson's disease and may decrease the effectiveness of Sinemet. Because patients may not recognize these behaviors as abnormal, it is important for prescribers to specifically ask patients or the caregivers about the development of new or increased gambling urges, sexual urges, uncontrolled spending or other urges while being treated with Sinemet.

For the reasons stated above, patients and providers are advised to monitor for melanomas frequently and on a regular basis when using Sinemet for any indication. The patient should be informed that Sinemet is an immediate-release formulation of carbidopa levodopa that is designed to begin release of ingredients within 30 minutes.

It is important that Sinemet be taken at regular intervals according to the schedule outlined by the physician. Patients should be advised that occasionally, dark color red, brown, or black may appear in saliva, urine, or sweat after ingestion of Sinemet. There have been reports of patients experiencing intense urges to gamble, increased sexual urges, and other intense urges, and the inability to control these urges while taking one or more of the medications that increase central dopaminergic tone and that are generally used for the treatment of Parkinson's disease, including Sinemet.

Prescribers should ask patients about the development of new or increased gambling urges, sexual urges or other urges while being treated with Sinemet. Patients should inform their physician if they experience new or increased gambling urges, increased sexual urges, or other intense urges while taking Sinemet. Commonly, levels of blood urea nitrogen, creatinine, and uric acid are lower during administration of Sinemet than with levodopa. Sinemet may cause a false-positive reaction for urinary ketone bodies when a test tape is used for determination of ketonuria.

False-negative tests may result with the use of glucose-oxidase methods of testing for glucosuria.

How should I take Sinemet?

Immediately telephone your doctor or Poisons Information Centre telephone 13 11 26or go to accident and emergency at your nearest hospital, if you think that you or anyone else may have taken too much SINEMET. Do this even if there are no signs of discomfort or poisoning.

While you are using SINEMET Things you must do If you feel light-headed, dizzy or faint get up slowly when getting out of bed or standing up. You may feel light-headed or dizzy while taking SINEMET. This is because your blood pressure is falling suddenly. Standing up slowly, especially when you get up from bed or chairs, will help your body get used to the change in position and blood pressure.

If this problem continues or gets worse, tell your doctor. If you are about to be started on any new medicine, tell your doctor and pharmacist that you are taking SINEMET.

What should I avoid while taking Sinemet?

Message BoardsConnect with people like you, and get expert guidance on living a healthy life. How to use Sinemet 10-100Take this medication by mouth with or without food as directed by your doctor, usually 3 to 4 times a day.

Tell your doctor if your condition does not improve or if it worsens. What conditions does Sinemet 10-100 treat. Side Effects Dizziness, lightheadedness, nausea, vomiting, loss of appetite, trouble sleeping, unusual dreams, or headache may occur. In the US -Call your doctor for medical advice about side effects.

Sinemet side effects

One of the big problems with Parkinson's disease is the broad range of motor and non-motor symptoms. Sometimes it is so difficult to sort the symptoms from the side effects of the medications. And that is just for treating PD. Many patients have more that one physical condition requiring medication. We know that after certain meds, my husband is going to feel really tired.

I try to time when he takes his medications and supplements and meals so that they can support each other but we still can't avoid the sleepiness he feels after some of them, Sinemet included. We are fortunate that my husband is not suffering from the Sinemet nausea which often abates after the first year. Following the steps of the exercise can also be difficult without someone to guide or lead.

Common Sinemet ide effects may include:

  • Furazolidone: Concomitant use of levodopa and drugs with monoamine oxidase inhibitor activity, such as furazolidone, can result in hypertensive crisis.

  • What happens if I take too much carbidopa-levodopa.


  • Quantity Limits Drugs that have quantity limits associated with each prescription.

Patients receiving levodopa single-agent therapy should avoid vitamin B6 supplements. Benztropine: Through its central antimuscarinic actions, antimuscarinics such as benztropine can potentiate the dopaminergic effects of levodopa. While some patients may benefit from this interaction, clinicians should be ready to decrease doses of levodopa if benztropine is added.

Where can I get more information?

  • Jump over to the doctors only platform.

  • It prevents metabolism of levodopa to dopamine in the peripheral circulation, ensuring that a higher proportion of the dose reaches the brain, where dopamine acts.