Generic Name: Sinemet cr
What is Sinemet Cr?
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects. Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention. Stop taking the medication and seek immediate medical attention if any of the following occur: Some people may experience side effects other than those listed.
Check with your doctor if you notice any symptom that worries you while you are taking this medication. Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health.
These factors may affect how you should take this medication. Behaviour and Mood Changes: This medication has been known to cause mood swings, changes in behaviour and symptoms of depression. If you have depression or a history of depression, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
You may notice compulsive behaviour, such as gambling, increased sexual activity or inappropriate spending. If you experience symptoms of depression such as poor concentration, changes in weight, changes in sleep, decreased interest in activities, contact your doctor as soon as possible.
Although it is not proven that the medications caused these events, these urges were reported to have stopped in some cases when the dose was reduced or the medication was stopped. Prescribers should ask patients about the development of new or increased gambling urges, sexual urges or other urges while being treated with SINEMET CR.
Patients should inform their physician if they experience new or increased gambling urges, increased sexual urges, or other intense urges while taking SINEMET CR. Physicians should consider dose reduction or stopping the medication if a patient develops such urges while taking SINEMET CR. RxList does not provide medical advice, diagnosis or treatment. Initial Dosage Patients currently treated with conventional carbidopa levodopa preparations: Studies show that peripheral dopa-decarboxylase is saturated by the bioavailable carbidopa at doses of 70 mg a day and greater.
A guideline for initiation of SINEMET CR is shown in Table 3. Patients currently treated with levodopa without a decarboxylase inhibitor Levodopa must be discontinued at least twelve hours before therapy with SINEMET CR is started. Titration With SINEMET CR Following initiation of therapy, doses and dosing intervals may be increased or decreased depending upon therapeutic response. An interval of at least 3 days between dosage adjustments is recommended.
Addition Of Other Antiparkinson Medications Anticholinergic agents, dopamine agonists, and amantadine can be given with SINEMET CR. Interruption Of Therapy Sporadic cases of hyperpyrexia and confusion have been associated with dose reductions and withdrawal of SINEMET or SINEMET CR.
Other adverse experiences reported overall in clinical trials in 748 patients treated with SINEMET CR, listed by body system in order of decreasing frequency, include: Body as a Whole Asthenia, fatigue, abdominal pain, orthostatic effects.
How should I take Sinemet Cr?
Duodenal delivery of levodopa for on-off fluctuations in parkinsonism: preliminary observations. Ten years' experience with enteral levodopa infusions for motor fluctuations in Parkison's disease. Clinical studies with and pharmacokinetic considerations of sustained-release levodopa. Levodopa: past present, and future. Effect of entacapone, a COMT inhibitor, on the pharmacokinetics and metabolism of levodopa after administration of controlled-release levodopa-carbidopa in volunteers.
The effect of cathecol-O-methyltransferease inhibition by entacapone on the pharmacokinetics and metabolism of levodopa in healthy volunteers. Effect of entacapone, a COMT inhibitor, on the pharmacokinetics of levodopa and on cardiovascular responses in patients with Parkinson's disease.
What should I avoid while taking Sinemet Cr?
If the amount of the extra dose needs to be adjusted, it is typically done in 0. The extra dose frequency should be limited to 1 extra dose every 2 hours. Administration of frequent extra doses may cause or worsen dyskinesias. When using a PEG-J tube, the drug can be discontinued by withdrawing the tube and letting the stoma heal. The removal of the tube should only be performed by a qualified healthcare provider.
The dosage may be increased by 1 tablet every day or every other day up to a maximum of 8 tablets per day. However, this may not provide an adequate amount of carbidopa for many patients.
Therefore, the dosage may be increased by 1 tablet every day or every other day up to a total of 8 tablets i.
Sinemet Cr side effects
Your doctor may prescribe you a stronger dose of SINEMET CR or may ask you to take it more frequently. Your doctor may need to prescribe you a different medicine.
Have blood tests when your doctor says to make sure SINEMET CR is not causing any problems with your blood, liver, kidneys or heart. If you plan to have surgery that needs a general anaesthetic, tell your doctor or dentist that you are taking SINEMET CR.
Be careful when driving or operating machinery until you know how SINEMET CR affects you.
Common Sinemet Cr ide effects may include:
Visit the FDA MedWatch website or call 1-800-FDA-1088.
Sinemet CR aims to overcome these problems by slowly releasing the active drugs levodopa and carbidopa over four to six hours.
If you accidentally take an overdose, you may experience one or more symptoms similar to those of levodopa overdose like vomiting, disorientation, agitation, insomnia, restlessness, low blood pressure and increased heart beat.
This action diminishes levodopa's therapeutic effects by decreasing the amount of levodopa that is available to cross into the CNS.
Benztropine: Through its central antimuscarinic actions, antimuscarinics such as benztropine can potentiate the dopaminergic effects of levodopa. While some patients may benefit from this interaction, clinicians should be ready to decrease doses of levodopa if benztropine is added. Beta-blockers: Concomitant use of beta-blockers with levodopa can result in additive hypotensive effects.
Where can I get more information?
In addition, patients should be monitored periodically for signs of neuropathy during treatment with the enteral suspension, particularly those with pre-existing neuropathy or who have a medical condition that may be associated with a risk for neuropathy e.
Perphenazine: Phenothiazines may inhibit the clinical antiparkinsonian response to levodopa by blocking dopamine receptors in the brain and levodopa may decrease the response to phenothiazines by increasing central dopamine levels.