Generic Name: Seroquel
What is Seroquel?
Clinical efficacy: In three placebo-controlled clinical trials, in patients with schizophrenia, using variable doses of quetiapine, there were no differences between the Seroquel and placebo treatment groups in the incidence of EPS or concomitant use of anti-cholinergics. In a 6-week, randomised, study of lithium and Seroquel XR versus placebo and Seroquel XR in adult patients with acute mania, the difference in YMRS mean improvement between the lithium add-on group and the placebo add-on group was 2.
Clinical safetyIn short-term, placebo-controlled clinical trials in schizophrenia and bipolar mania the aggregated incidence of extrapyramidal symptoms was similar to placebo schizophrenia: 7.
Higher rates of extrapyramidal symptoms were seen in quetiapine-treated patients compared to those treated with placebo in short-term, placebo-controlled clinical trials in MDD and bipolar depression. The incidence of somnolence was higher in the Seroquel XR with lithium add-on group 12. Longer term relapse prevention trials had an open label period ranging from 4 to 36 weeks during which patients were treated with quetiapine, followed by a randomised withdrawal period during which patients were randomised to quetiapine or placebo.
For patients who were randomised to quetiapine, the mean weight gain during the open label period was 2. In a third short-term placebo-controlled monotherapy trial with Seroquel XR in children and adolescent patients 10-17 years of age with bipolar depression, efficacy was not demonstrated.
Clinical safetyIn the short-term paediatric trials with quetiapine described above, the rates of EPS in the active arm vs.
For this drug to work well, a certain amount needs to be in your body at all times. You could have dangerous levels of the drug in your body. If your symptoms are severe, call 9-1-1 or go to the nearest emergency room right away.
Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.
You should take quetiapine extended-release tablets without food or with a light meal about 300 calories. Symptoms can include hot skin, excessive sweating, fast heartbeat, rapid breathing, and even seizures. To help prevent this:You and your doctor should monitor certain health issues. This can help make sure you stay safe while taking this drug. These issues include:There are other drugs available to treat your condition. Some may be better suited for you than others.
Talk to your doctor about other drug options that may work for you. Why it's used Quetiapine is used to treat the symptoms of schizophrenia, bipolar disorder, or depression.
How should I take Seroquel?
This drug has caused me to have severe panic attacks and multiple hospitalizations. My blood pressure has skyrocketed,I have now got tachycardia, have panic attacks every night, get intense migraines and lose control of my muscle movements at times. I would absolutely not recommend this medication to anybody. It has ruined my life and health and it should be taken off the market. Report 5 StarsRated Seroquel Quetiapine for Schizophrenia Report I've tried many medications over the past 35 years and hated every time I did.
What should I avoid while taking Seroquel?
Suicide is a known risk of depression and certain other psychiatric disorders, and these disorders themselves are the strongest predictors of suicide. There has been a long-standing concern, however, that antidepressants may have a role in inducing worsening of depression and the emergence of suicidality in certain patients during the early phases of treatment.
Pooled analyses of short-term placebo-controlled trials of antidepressant drugs SSRIs and others showed that these drugs increase the risk of suicidal thinking and behavior suicidality in children, adolescents, and young adults ages 18-24 with major depressive disorder MDD and other psychiatric disorders.
The pooled analyses of placebo-controlled trials in children and adolescents with MDD, obsessive compulsive disorder OCDor other psychiatric disorders included a total of 24 short-term trials of 9 antidepressant drugs in over 4400 patients. The pooled analyses of placebo-controlled trials in adults with MDD or other psychiatric disorders included a total of 295 short-term trials median duration of 2 months of 11 antidepressant drugs in over 77,000 patients.
Seroquel side effects
AstraZeneca disclosed the settlement in a financial report. AstraZeneca also said it had been served with 14,444 civil lawsuits over the drug as of Oct. Ed Blizzard, a lawyer for some of the people suing AstraZeneca, said Thursday that many patients have developed diabetes and other health problems because of misleading marketing. Blizzard said he did not know what clinical trials were part of the inquiry. A version of this article appears in print on October 30, 2009, on Page B2 of the New York edition with the headline: AstraZeneca Pays Millions To Settle Seroquel Cases.
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Common Seroquel ide effects may include:
Seroquel and Seroquel XR are antipsychotic medicines that contain the active substance quetiapine.
This leaflet answers some of the common questions people ask about SEROQUEL XR.
Seniors: There may be a higher risk of strokes, heart attacks, infections e.
DO NOT miss a dose.
What are the conclusions of the CHMP. The areas harmonised include:4. Seroquel XR can also continue to be used as add-on to ongoing treatment for major depressive episodes in patients with major depressive disorder who have had sub-optimal response to treatment with other antidepressants. Other changesThe CHMP also harmonised other sections of the SmPC including sections 4. The states alleged that salespeople for AstraZeneca promoted its anti-psychotic Seroquel for off-label, or unapproved uses, and did not disclose side effects of the pill, which include weight gain and muscle spasms.
Where can I get more information?
The FDA found that young people who used Seroquel to treat major depressive disorder were more prone to suicidal thoughts and behaviors than depressed adolescents and young adults who took a placebo.
This may not be a complete list of all interactions that may occur.