Generic Name: Rifadin
What is Rifadin?
Salicylates can also displace methotrexate from protein-binding sites. Although the risk for drug interactions with methotrexate is greatest during high-dose methotrexate therapy, it has been recommended that any of these drugs be used cautiously with methotrexate even when methotrexate is used in low doses for the treatment of rheumatoid arthritis.
A significantly higher incidence of leukopenia has been reported in patients taking aspirin during methotrexate therapy. Acitretin: The combination of methotrexate and acitretin is contraindicated. An increased risk of hepatitis has been reported from the combined use of methotrexate and the retinoid etretinate. Acitretin is the principal active component of etretinate.
Although no longer available commercially in the United States, etretinate has been shown to increase methotrexate serum concentrations and cases of hepatotoxicity e.
Adalimumab: The safety and efficacy of adalimumab in patients with immunosuppression have not been evaluated. The apparent clearance of adalimumab was decreased by 29 percent after a single dose and by 44 percent after multiple doses of methotrexate. The mean steady state trough concentration of adalimumab was 8 to 9 mcg, ml with concomitant methotrexate versus 5 mcg, ml without methotrexate use. However, no dose adjustment for either drug is needed when methotrexate and adalimumab are used together.
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins and herbal supplements. Especially tell your doctor if you take:This is not a complete list of methotrexate drug interactions. Medicines can interact with certain foods.
In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of methotrexate there are no specific foods that you must exclude from your diet when receiving this medication. Before taking methotrexate, tell your doctor about all of your medical conditions. Especially tell your doctor if you:Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy. This medication falls into category X. Methotrexate may cause death or serious harm to your unborn baby. Tell your doctor if you are breastfeeding or plan to breastfeed. You should not breastfeed while taking methotrexate as it is excreted into human breast milk and may harm your nursing baby.
Take this medication exactly as prescribed by your doctor.
How should I take Rifadin?
There is a very low risk of developing leukemia, sarcoma, lung cancer or other types of cancer due to treatment with this medication, which can occur many years after treatment. This is most often associated with repeated treatments or high doses. This medication can impact your kidney function. Call your doctor or nurse if you do not urinate for more than 12 hours. This medication may cause interstitial pneumonitis, particularly when high doses have been received. These problems can develop months to years after treatment is completed and may be more common in people with pre-existing lung conditions.
Notify your healthcare provider if you develop fever, shortness of breath, non productive cough, wheezing or difficulty breathing.
What should I avoid while taking Rifadin?
Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. It is important to prevent pregnancy during and after treatment with methotrexate. Therefore, males and females must use reliable forms of birth control such as condoms, birth control pills during treatment.
Males should continue to use birth control for at least 3 months after the end of treatment. Females should continue to use birth control for at least 1 menstrual cycle after the end of treatment.
If you become pregnant or think you may be pregnant, tell your doctor right away. Methotrexate passes into breast milk and may harm a nursing infant. Therefore, breast-feeding while using this drug is not recommended.
Rifadin side effects
Autism Health News Feed From Rheumatoid Arthritis Resources Treating RA With Biologics Care for Your RA Are You Ready for Back Surgery. The tendency to develop ankylosing spondylitis is genetically inherited. Treatment incorporates medications, physical therapy, and exercise. Treatment depends upon the cause of the liver disease. Polymyalgia rheumatica PMR is a disorder of the muscles and joints that causes pain and stiffness in the arms, neck, shoulders, and buttocks.
Common Rifadin ide effects may include:
Although an interaction between vinblastine and methotrexate has not been reported by the manufacturer, it is prudent to consider that vinblastine may have similar interactions as those for other vinca alkaloids, including interactions with methotrexate.
Tell your doctor if any of these symptoms are severe or do not go away: dizzinessdrowsinessheadacheswollen, tender gumsdecreased appetitereddened eyeshair lossSome side effects can be serious.
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A fourth mechanism, decreased formation of MTX-PG, can also occur and may be important for resistance to high-dose methotrexate.
Bexarotene: Concomitant use of systemic retinoids, such as bexarotene, and methotrexate could increase risk of liver-related side effects of methotrexate and such patients should be monitored closely during methotrexate therapy. Topical retinoid products do not appear to pose this increased risk for liver problems. Bismuth Subsalicylate: Caution should be exercised when salicylates are given in combination with methotrexate.
Bivalirudin: Due to the thrombocytopenic effects of folate analogs, when used as antineoplastic agents, an additive risk of bleeding may be seen in patients receiving concomitant anticoagulants.
Where can I get more information?
If you are a woman, use an effective form of birth control while you are taking methotrexate, and for at least one cycle of ovulation after your treatment ends.
Rheumatrex - Clinical PharmacologyMethotrexate inhibits dihydrofolic acid reductase.