Generic Name: Rheumatrex

What is Rheumatrex?

Methotrexate can be given by mouth or by injection intramuscular, intravenous, subcutaneous, or intrathecal. It has a variety of cutaneous side effects, particularly when administered in high doses. People with cancer who receive the medication often nickname these effects "chemo brain" or "chemo fog". It is thought to affect cancer and rheumatoid arthritis by two different pathways.

For cancer, methotrexate competitively inhibits dihydrofolate reductase DHFRan enzyme that participates in the tetrahydrofolate synthesis.

DHFR catalyses the conversion of dihydrofolate to the active tetrahydrofolate. Do not get lured by unbelievable low prices, they may be FAKE DRUGS!. Generic Amethopterin - Emthexate - Rheumatrex - Trexall - Methotrexate is also used in other cancers like blood, breast and lung cancers.

Generic Amethopterin - Emthexate - Rheumatrex - Trexall - Methotrexate is also used to suppress immunity in conditions such as psoriasis and rheumatoid arthritis.

Findings: This study found moderate, but not statistically significant decreases in steroid use when taking methotrexate. But these medicines can cause serious injury if a mistake happens while taking them. This means that it is very important for you to know about this medicine and take it exactly as directed. Methotrexate is a cancer medicine.

However, it is also used to treat other conditions like rheumatoid arthritis and psoriasis. It works well for these conditions if you take the medicine just once or twice a week, and in smaller doses. But if you take the medicine every day by accident, you could be harmed. Sadly, some people have even died. In several instances, this happened because people misread the directions on the prescription bottle.

In one case, a man with arthritis mistakenly took one tablet each morning, but the directions said to take one tablet each Monday. In another case, the prescription label said to take the medicine every 12 hours for just three doses. But a woman took the medicine every 12 hours for 6 days in a row.

How should I take Rheumatrex?

It is recommended to give L-asparaginase or pegaspargase at least 10-14 days prior to methotrexate or shortly after methotrexate administration. Pegfilgrastim: Pegfilgrastim induces the proliferation of neutrophil-progenitor cells, and, because antineoplastic agents exert their toxic effects against rapidly growing cells, pegfilgrastim should not be given 14 days before or for 24 hours after cytotoxic chemotherapy. Peginterferon beta-1a: Due to its potential to decrease peripheral blood cell counts, proper monitoring of patients is required if peginterferon beta-1a is given in combination with immunosuppressives or antineoplastic agents.

Penicillamine: Concomitant use of penicillamine with antineoplastic agents is contraindicated because of the increased risk of developing severe hematologic and renal toxicity. Antineoplastic agents have adverse reactions similar to those of penicillamine. Penicillins: Penicillins may reduce the renal clearance of methotrexate. Increased serum concentrations of methotrexate with concomitant hematologic and gastrointestinal toxicity have been observed with concurrent administration of high or low doses of methotrexate and penicillins.

Patients should be carefully monitored while receiving this combination.

What should I avoid while taking Rheumatrex?

In psoriatic patients, hepatotoxicity appears to be a function of the cumulative dose. Manufacturer recommendations for liver biopsy in psoriatic patients are to obtain biopsies prior to therapy or shortly after initiating therapy i. However, psoriasis guidelines suggest that 3. The National Psoriasis Foundation suggests 3 options in patients without risk factors for hepatic toxicity who reach a cumulative dose of 3.

In patients with at least 1 risk factor for hepatic toxicity, consider delayed baseline liver biopsy after 2 to 6 months of therapy to establish medication efficacy and tolerability and avoid unnecessary biopsies in those who do not tolerate the drug or show a lack of response with repeated biopsies after every 1 to 1.

Rheumatrex side effects

A key finding suggests that growth in health care spending has coincided with an increase in products and services that together reduce mortality rates and promote additional health gains. Concerns over the apparent increase in unit prices of medical care may thus understate positive impacts on consumer welfare. When appropriately adjusted for such quality improvements, health care prices may actually have fallen. Methotrexate is an antimetabolite that is prescribed, alone or together with other agents, to help treat certain types of cancer.

It is also prescribed for the treatment of severe psoriasis or severe active rheumatoid arthritis that cannot be controlled by other treatments. It is indicated to treat severe psoriasis, rheumatoid arthritis, or certain forms of cancer when other treatments have proven to be ineffective.

It belongs to the class of drugs called antimetabolites. Before being prescribed this medicine, the possible side effects must be discussed with your doctor.

Common Rheumatrex ide effects may include:

  • Tell your doctor if any of these symptoms are severe or do not go away:dizzinessdrowsinessheadacheswollen, tender gumsdecreased appetitereddened eyeshair lossSome side effects can be serious.

  • Live Vaccines: Live virus vaccines should generally not be administered to an immunosuppressed patient.

  • See also Precautions section.

  • Limited data suggest initial clinical improvement may be seen for 2 years with continued therapy.

Excellent correlation has been reported between methotrexate clearance and endogenous creatinine clearance. Methotrexate clearance rates vary widely and are generally decreased at higher doses.

Delayed drug clearance has been identified as one of the major factors responsible for methotrexate toxicity. It has been postulated that the toxicity of methotrexate for normal tissues is more dependent upon the duration of exposure to the drug rather than the peak level achieved. When a patient has delayed drug elimination due to compromised renal function, a third space effusion, or other causes, methotrexate serum concentrations may remain elevated for prolonged periods.

Where can I get more information?

  • Maximal myelosuppression usually occurs in seven to ten days.

  • What are the possible side effects of methotrexate Rheumatrex Dose Pack, Trexall.