Generic Name: Rheumatrex
What is Rheumatrex?
During therapy of rheumatoid arthritis and psoriasis, monitoring of these parameters is recommended: hematology at least monthly, renal function and liver function every 1 to 2 months.
More frequent monitoring is usually indicated during antineoplastic therapy. During initial or changing doses, or during periods of increased risk of elevated methotrexate blood levels eg, dehydrationmore frequent monitoring may also be indicated. Transient liver function test abnormalities are observed frequently after methotrexate administration and are usually not cause for modification of methotrexate therapy.
A relationship between abnormal liver function tests and fibrosis or cirrhosis of the liver has not been established for patients with psoriasis. Persistent abnormalities in liver function tests may precede appearance of fibrosis or cirrhosis in the rheumatoid arthritis population.
Pulmonary function tests may be useful if methotrexate-induced lung disease is suspected, especially if baseline measurements are available. Concomitant administration of some NSAIDs with high dose methotrexate therapy has been reported to elevate and prolong serum methotrexate levels, resulting in deaths from severe hematologic and gastrointestinal toxicity.
Isometric exercises would place stress on joints and would not be recommended. Stretching and ROM should be done later in the day, when joint stiffness is decreased. The biologic agent anakinra Kineret is prescribed for a patient who has moderately severe rheumatoid arthritis RA.
When teaching the patient about this drug, the nurse will include information abouta. Answer: BRationale: Anakinra is administered by subcutaneous injection.
GI bleeding is not a side effect of this medication. Because the medication is injected, instructions to take it with 8 oz of fluid would not be appropriate. The patient is likely to be concurrently taking aspirin or NSAIDs and these should not be discontinued. A 35-year-old patient with three school-age children who has recently been diagnosed with rheumatoid arthritis RA tells the nurse that the inability to be involved in many family activities is causing stress at home.
Answer: CRationale: Deep-breathing exercises are used to decrease the risk for pulmonary complications that may occur with the reduced chest expansion that can occur with ankylosing spondylitis AS.
How should I take Rheumatrex?
Diclofenac: In general, NSAID therapy can decrease the clearance of methotrexate, resulting in elevated and prolonged serum methotrexate levels. Diflunisal: In general, NSAID therapy can decrease the clearance of methotrexate, resulting in elevated and prolonged serum methotrexate levels. Digoxin: Some antineoplastic agents have been reported to decrease the absorption of digoxin tablets due to their adverse effects on the GI mucosa.
For the digoxin tablets, there was a significant reduction in the AUC after chemotherapy to 54. It is prudent to closely monitor patients for loss of clinical efficacy of digoxin tablets while they are receiving chemotherapy.
What should I avoid while taking Rheumatrex?
In addition, a reduction in red blood cells caused by Cellcept may lead to anemia, which could make you tired or lead to easy bruising. Cellcept can also reduce the number of platelets in your blood, which may also cause easy bruising or gastrointestinal bleeding bleeding anywhere along the pathway that food travels in the body.
Obtaining periodic blood tests while taking Cellcept can help you and your doctor to detect and correct these problems.
Blood tests should be performed frequently during the first several months of taking this medication and less often as more time passes. People over 65 and those that have experienced ulcers or other gastrointestinal disorders should speak to their doctors before taking Cellcept. People in these groups may experience an increased risk of side effects. In addition, there may be an increased risk of developing cancer such as lymphoma and skin cancer when taking immunosuppressives such as Cellcept.
You should discuss this with your doctor before beginning this medication.
Rheumatrex side effects
In psoriasis and rheumatoid arthritis, methotrexate should be stopped immediately if there is a significant drop in blood counts. In the treatment of neoplastic diseases, methotrexate should be continued only if the potential benefit warrants the risk of severe myelosuppression.
Patients with profound granulocytopenia and fever should be evaluated immediately and usually require parenteral broad-spectrum antibiotic therapy. Hepatic: Methotrexate has the potential for acute elevated transaminases and chronic fibrosis and cirrhosis hepatotoxicity.
In studies in psoriatic patients, hepatotoxicity appeared to be a function of total cumulative dose and appeared to be enhanced by alcoholism, obesity, diabetes and advanced age. Special caution is indicated in the presence of preexisting liver damage or impaired hepatic function.
Common Rheumatrex ide effects may include:
Increasing the dosage of the drug will not accelerate the effectiveness of it.
What is methotrexate Rheumatrex Dose Pack, Trexall.
Folinic acid 15 mg orally or IV every 6 hours for 4 doses was given 24 hours after each methotrexate dose.
A key finding suggests that growth in health care spending has coincided with an increase in products and services that together reduce mortality rates and promote additional health gains.
It is possible that kava kava would act synergistically with other medications that can have adverse effects on the liver, such as methotrexate. Ketoprofen: In general, NSAID therapy can decrease the clearance of methotrexate, resulting in elevated and prolonged serum methotrexate levels.
Ketorolac: In general, NSAID therapy can decrease the clearance of methotrexate, resulting in elevated and prolonged serum methotrexate levels.
Where can I get more information?
Alcoholic beverages should not be consumed while taking methotrexate, as it could cause damage to the liver, leading to cirrhosis.
Immunosuppressive medications are used to control more serious lupus activity that affects major organs, including the kidney, brain, cardiovascular system, and lungs.