Generic Name: Revatio

What is Revatio?

Additionally, GZDV half-life in these patients was 8. Patients received escalating doses of zidovudine up to 200 mg five times daily for 8 weeks. Daily doses of 500 mg or less were well tolerated despite significantly elevated plasma levels of GZDV. Proportional increases in AUC and in zidovudine concentrations were observed with increasing dose, consistent with dose-independent kinetics over the dose range studied.

The mean terminal half-life and total body clearance across all dose levels administered were 1. These values compare to mean half-life and total body clearance in adults of 1. This value is the same as the bioavailability in adults. The pharmacokinetics of zidovudine has been studied in neonates from birth to 3 months of life. In one study of the pharmacokinetics of zidovudine in women during the last trimester of pregnancy, zidovudine elimination was determined immediately after birth in 8 infants who were exposed to zidovudine in utero.

In another study, the pharmacokinetics of zidovudine was evaluated in infants ranging in age of 1 day to 3 months of normal birth weight for gestational age and with normal renal and hepatic function. In infants greater than 14 days, total body clearance was 19.

Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy. This medication falls into category C. In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans.

Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child. You should know that transmission of HIV infection may still occur in some cases despite therapy with Retrovir. Talk to your doctor about participating in a pregnancy registry that monitors outcomes in pregnant women who are also taking this medication.

The Centers for Disease Control and Prevention recommend that HIV-infected mothers not breastfeed in order to avoid risking transmission of HIV infection. Avoid doing things that can spread HIV infection to others:Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully. If you take too much this medication, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

If this medication is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention. Do not miss any doses.

How should I take Revatio?

No antagonistic effects in vitro were seen with zidovudine and other antiretrovirals tested agents: abacavir, didanosine, lamivudine and interferon-alpha. Resistance to thymidine analogues of which zidovudine is one is well characterised and is conferred by the stepwise accumulation of up to six specific mutations in the HIV reverse transcriptase at codons 41, 67, 70, 210, 215 and 219.

Viruses acquire phenotypic resistance to thymidine analogues through the combination of mutations at codons 41 and 215 or by the accumulation of at least four of the six mutations.

These thymidine analogue mutations alone do not cause high-level cross-resistance to any of the other nucleosides, allowing for the subsequent use of any of the other approved reverse transcriptase inhibitors.

Two patterns of multi-drug resistance mutations, the first characterised by mutations in the HIV reverse transcriptase at codons 62, 75, 77, 116 and 151 and the second involving a T69S mutation plus a 6-base pair insert at the same position, result in phenotypic resistance to AZT as well as to the other approved nucleoside reverse transcriptase inhibitors.

What should I avoid while taking Revatio?

Find out if it's right for you. Get a quick quote. Precautions and Side Effects Zidovudine should not be used in animals with known hypersensitivity or allergy to the drug.

Drug Interactions with AZT AZT may interact with other medications. How Zidovudine is Supplied Zidovudine is available in 300 mg oral tablets and 100 mg capsules.

Revatio side effects

Zidovudine is primarily eliminated by hepatic conjugation to an inactive glucoronidated metabolite. Renal clearance of zidovudine greatly exceeds creatinine clearance, indicating that significant tubular secretion takes place. The major metabolite is 5'-glucuronide.

Renal clearance of zidovudine greatly exceeds creatinine clearance indicating that significant tubular secretion takes place. The data available on the pharmacokinetics in neonates and young infants indicate that glucuronidation of zidovudine is reduced with a consequent increase in bioavailability, reduction in clearance and longer half-life in infants less than 14 days old but thereafter the pharmacokinetics appear similar to those reported in adults. The pharmacokinetics of zidovudine has been investigated in a study of eight women during the third trimester of pregnancy.

Common Revatio ide effects may include:

  • The concomitant use of rifampicin or stavudine with zidovudine should be avoided see section 4.

  • RETROVIR injection should not be given intramuscularly.

  • The indication is based on a dosing regimen that included 3 components: 1.

  • This medication passes into breast milk.

Nevirapine Nevirapine is a non-nucleoside reverse transcriptase inhibitor NNRTI used to treat HIV-1 infection and AIDS. Chemical Information Download Zidovudine SDF Molecular Weight 267.

Tenofovir Tenofovir blocks reverse transcriptase and hepatitis B virus infections. Features:Tenofovir disoproxil fumarate is the prodrug form of tenofovir. Will I experience any side effects.

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  • Alternatively, dosing for RETROVIR can be based on body surface area BSA for each child.

  • RETROVIR was well tolerated by mothers and infants.