Generic Name: Retrovir

What is Retrovir?

These lists are not exhaustive. AZT should never be combined with d4T Zerit, stavudineas these drugs interfere with each other. Aspirin, codeine, morphine and a number of other drugs can also affect the metabolism of AZT, so use of these drugs should be discussed with your doctor. The antibiotic clarithromycin can reduce the absorption of AZT. This can be avoided by taking the two medications at least two hours apart.

Over time, as new copies of HIV are made in the body, the virus changes its structure. These changes are called mutations and can cause HIV to resist the effects of anti-HIV drugs, which means those drugs will no longer work for you. Combining AZT with at least two other anti-HIV drugs delays the development of drug resistance.

These cells normally work to activate other cells in the immune system to fight infection. Since HIV kills CD4 T-helper cells, over time the body becomes less able to fight the virus or subsequent infections. There is no cure for HIV, but zidovudine is one of several medicines that lower the amount of virus in the body viral loadhelp the immune system to recover, and therefore slow down or stop the progression of the disease from HIV to AIDS. A combination of several anti-HIV medicines is required to fight HIV because the virus can become resistant to one agent very quickly.

This is known as combined antiretroviral therapy cART or highly active antiretroviral therapy HAART. Zidovudine is used in combination with other anti-HIV drugs that attack the HIV virus in different ways. This minimises the virus's ability to replicate and multiply, and helps prevent it becoming resistant to treatment. This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately. Certain medicines should not be used during pregnancy or breastfeeding.

How should I take Retrovir?

Other large studies of longer duration have not shown additional survival benefit of early versus delayed therapy with Retrovir above that seen for patients with advanced HIV disease. The probability of remaining free of opportunistic infections through 12 months of follow-up was 0.

Improvements in CD4 cell counts and normalization of immunoglobulin concentration were observed among the patients receiving Retrovir. An antiretroviral effect was demonstrated by reductions in serum and CSF p24 antigen concentrations, as well as by a reduction in the number of patients with positive CSF HIV cultures.

Oral Retrovir was initiated between 14 and 34 weeks of gestation median 11 weeks of therapy followed by intravenous administration of Retrovir during labor and delivery. After birth, infants received oral Retrovir Syrup for 6 weeks.

The study showed a statistically significant difference in the incidence of HIV infection in the infants based on viral culture from peripheral blood between the group receiving Retrovir and the group receiving placebo.

What should I avoid while taking Retrovir?

The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Be certain to complete the prescription unless specifically directed by your veterinarian. Find out if it's right for you. Get a quick quote. Precautions and Side Effects Zidovudine should not be used in animals with known hypersensitivity or allergy to the drug.

Drug Interactions with AZT AZT may interact with other medications. How Zidovudine is Supplied Zidovudine is available in 300 mg oral tablets and 100 mg capsules.

Retrovir side effects

RETROVIR injection is a clear, nearly colorless, sterile aqueous solution with a pH of approximately 5. Each vial contains 200 mg of zidovudine in 20 mL solution 10 mg per mL.

Storage And Handling RETROVIR 100-mg capsules are supplied as white, opaque cap and body capsules containing 100 mg zidovudine per capsule. Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice.

Adults The frequency and severity of adverse reactions associated with the use of RETROVIR are greater in patients with more advanced infection at the time of initiation of therapy. Pediatrics The clinical adverse reactions reported among adult recipients of RETROVIR may also occur in pediatric patients.

Use For The Prevention Of Maternal-Fetal Transmission Of HIV-1 In a randomized, double-blind, placebo-controlled trial in HIV-1-infected women and their neonates conducted to determine the utility of RETROVIR for the prevention of maternal-fetal HIV-1 transmission, RETROVIR syrup at 2 mg per kg was administered every 6 hours for 6 weeks to neonates beginning within 12 hours following birth.

Postmarketing Experience The following adverse reactions have been identified during post-approval use of RETROVIR.

Common Retrovir ide effects may include:

  • Studies in cell culture suggest that zidovudine incorporation by cellular alpha-DNA polymerase may occur, but only to a very small extent and not in all test systems.

  • In the case of this medication, there are no specific foods that you must exclude from your diet.

  • Combination brands are available as tabletsDo not drive and do not use tools or machines while affected.

  • Myopathy Myopathy and myositis with pathological changes, similar to that produced by HIV-1 disease, have been associated with prolonged use of RETROVIR.

Overall, zidovudine doubled the risk of anaemia, but this was also increased by higher viral loads and lower haemoglobin levels before starting therapy. The analysis also found that taking zidovudine in Combivir or Trizivir almost doubled the risk of anaemia, but the reasons for this are unknown. See Anaemia for more information on the treatment of anaemia. There is a small risk of muscle damage myopathy after prolonged treatment with zidovudine, with some pain, wasting and weakness usually in the muscles around the hips, thighs and buttocks.

Where can I get more information?

  • Dubin G, Braffman MN "Zidovudine-induced hepatotoxicity.

  • The AMT AUC was one-fifth of the zidovudine AUC.