Generic Name: Renova
What is Renova?
It would be illogical to administer phosphate or phosphorus salts to patients who require sevelamer. Cyclosporine: Although drug interaction studies have not been conducted, it may be prudent to separate the timing of administration of cyclosporine from sevelamer.
According to the manufacturer of sevelamer, clinicians should consider separating the timing of administration of sevelamer and drugs where a reduction in the bioavailability of would have a clinically significant effect on its safety or efficacy.
The duration of separation should be based on the absorption characteristics of the coadministered drug. Because cyclosporine has a narrow therapeutic index, consider monitoring clinical response and serum concentrations during concurrent use of sevelamer. Serum thyroxine was measured at intervals over a 6-hour period following drug ingestion. Sevelamer significantly p Dichlorphenamide: Use dichlorphenamide and sevelamer together with caution as both drugs can cause metabolic acidosis.
Concurrent use may increase the severity of metabolic acidosis. Measure sodium bicarbonate concentrations at baseline and periodically during dichlorphenamide treatment. If metabolic acidosis occurs or persists, consider reducing the dose or discontinuing dichlorphenamide therapy. Digoxin: Studies of concomitant sevelamer and digoxin have not demonstrated an interaction. Administer digoxin at least 1 hour before or 3 hours after sevelamer doses and monitor digoxin drug concentrations to minimize the potential for a drug interaction.
It may be necessary to use other medicines with Renagel, which could include calcium or vitamin D supplements, to control the development of renal bone disease. Take special care with Renagel If any of the following applies to you, please consult your doctor before taking Renagel :The safety and efficacy in children below the age of 18 years has not been established.
Therefore Renagel is not recommended for use in this population. Additional treatments:Due to either your kidney condition or your dialysis treatment you may:Changing treatment:When you switch from another phosphate binder to Renagel, your doctor might consider monitoring the levels of bicarbonate in your blood more closely because Renagel may decrease the levels of bicarbonate.
You may develop peritonitis infection of your abdominal fluid associated with your peritoneal dialysis. This risk can be reduced by careful adherence to sterile techniques during bag changes. You should tell your doctor immediately if you experience any new signs or symptoms of abdominal distress,abdominal swelling, abdominal pain, abdominal tenderness, or abdominal rigidity, constipation, fever, chills, nausea or vomiting. You should expect to be monitored more carefully for problems with low levels of vitamins A, D, E, K and folic acid.
Taking other medicinesPlease tell your doctor if you are taking or have recently taken other medicines, including medicines obtained without a prescription. If you are taking medicines for heart rhythm problems or for epilepsy, you should consult your doctor when taking Renagel.
The effects of medicines such as ciclosporin, mycophenolate mofetil and tacrolimus medicines used in transplant patients may be reduced by Renagel. Your doctor will advise you if you are taking these medicines.
How should I take Renova?
Most commonly, these are "non-preferred" brand drugs. Most commonly, these are "non-preferred" brand drugs or specialty prescription products. NC NOT COVERED - Drugs that are not covered by the plan. Code Definition PA Prior Authorization Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription. QL Quantity Limits Drugs that have quantity limits associated with each prescription.
This restriction typically limits the quantity of the drug that will be covered.
What should I avoid while taking Renova?
Sevelamer hydrochloride Renagel is available as a tablet, in both 400 mg and 800 mg strengths. What is are the advantages and disadvantages of using sevelamer hydrochloride Renagel. Sevelamer hydrochloride is a calcium-free, metal-free, nonabsorbed phosphate binder that has proven effective in controlling serum phosphorous levels in patients with chronic kidney disease.
What are advantages and disadvantages of using sevelamer carbonate Renvela. Sevelamer carbonate is also available in powder packets for oral suspension. The powder packets are sprinkled into a prescribed amount of water depending on the strength.
The powder packets are a great advantage for those patients who have a hard time swallowing tablets or capsules.
Renova side effects
LevothyroxineDuring post marketing experience, very rare cases of increased thyroid stimulating hormone TSH levels have been reported in patients co-administered sevelamer hydrochloride and levothyroxine. Closer monitoring of TSH levels is therefore recommended in patients receiving both medicinal products. Ciclosporin, mycophenolate mofetil and tacrolimus in transplant patientsReduced levels of ciclosporin, mycophenolate mofetil and tacrolimus have been reported in transplant patients when coadministered with sevelamer hydrochloride without any clinical consequences i.
The possibility of an interaction cannot be excluded and a close monitoring of blood concentrations of mycophenolate mofetil, ciclosporin and tacrolimus should be considered during the use of combination and after its withdrawal.
Digoxin, warfarin, enalapril or metoprolol In interaction studies in healthy volunteers, Renagel had no effect on the bioavailability of digoxin, warfarin, enalapril or metoprolol.
Proton pump inhibitorsDuring post-marketing experience, very rare cases of increased phosphate levels have been reported in patients taking proton pump inhibitors co-administered with sevelamer hydrochloride. BioavailabilityRenagel is not absorbed and may affect the bioavailability of other medicinal products. When administering any medicinal product where a reduction in the bioavailability could have a clinically significant effect on safety or efficacy, the medicinal product should be administered at least one hour before or three hours after Renagel, or the physician should consider monitoring blood levels.
Common Renova ide effects may include:
Taking other medicinesPlease tell your doctor if you are taking or have recently taken other medicines, including medicines obtained without a prescription.
Before you use Renagel When you must not take it Do not take Renagel if you have an allergy to:hypophosphatemia, a condition where you do not have enough phosphorus in your bodyIf you take this medicine after the expiry date it may have no effect at all, or worse, an unexpected effect.
Dialysis removes some phosphate from your blood, but it is difficult to remove enough to keep your phosphate levels balanced.
Dose Titration for All Patients Taking Renagel Dosage should be adjusted based on the serum phosphorus concentration with a goal of lowering serum phosphorus to 5.
This restriction typically limits the quantity of the drug that will be covered. ST Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription. OR Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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Where can I get more information?
The recommended monitoring parameters include serum phosphate, calcium, chloride and bicarbonate concentrations.
In an in vitro mammalian cytogenetic test with metabolic activation, sevelamer hydrochloride caused a statistically significant increase in the number of structural chromosome aberrations.