Generic Name: Prevacid
What is Prevacid?
Q: Is it safe to take Prevacid for more than 5 years. I have been taking it for at least that long. I am hoping it doesn't cause long-term damage to any organs, etc. A: Prevacid lansoprazole is a medication used to treat acid reflux, ulcers, and esophageal erosion. It is in a class of medications called proton pump inhibitors and decreases the amount of acid in the stomach by blocking the acid production sites proton pumps in the stomach. There have been studies that have found that patients taking proton pump inhibitors, like Prevacid, may be at an increased risk for broken bones.
The risk is highest in patients who take these types of medications at high doses for long periods of time. It is believed that these medications may reduce the absorption of calcium in the digestive system that is needed to keep bones strong.
After oral administration, lansoprazole was shown to significantly decrease the basal acid output and significantly increase the mean gastric pH and percent of time the gastric pH was greater than three and greater than four. Lansoprazole also significantly reduced meal-stimulated gastric acid output and secretion volume, as well as pentagastrin-stimulated acid output.
In patients with hypersecretion of acid, lansoprazole significantly reduced basal and pentagastrin-stimulated gastric acid secretion. Lansoprazole inhibited the normal increases in secretion volume, acidity and acid output induced by insulin. The intragastric pH results of a five-day, pharmacodynamic, crossover study of 15 mg and 30 mg of once daily lansoprazole are presented in Table 4:Table 4: Mean Antisecretory Effects After Single and Multiple Daily PREVACID Dosing Baseline Value PREVACID 15 mg 30 mg Day 1 Day 5 Day 1 Day 5 Mean 24 Hour pH 2.
After the initial dose in this study, increased gastric pH was seen within one to two hours with 30 mg of lansoprazole and two to three hours with 15 mg of lansoprazole. After multiple daily dosing, increased gastric pH was seen within the first hour post-dosing with 30 mg of lansoprazole and within one to two hours post-dosing with 15 mg of lansoprazole.
There was no indication of rebound gastric acidity. Gastric biopsy specimens from the body of the stomach from approximately 150 patients treated continuously with lansoprazole for at least one year did not show evidence of ECL cell effects similar to those seen in rat studies. Lansoprazole did not significantly affect mucosal blood flow in the fundus of the stomach.
Lansoprazole significantly slowed the gastric emptying of digestible solids. Lansoprazole increased serum pepsinogen levels and decreased pepsin activity under basal conditions and in response to meal stimulation or insulin injection.
How should I take Prevacid?
However, due to the sustained action of proton pump inhibitors PPIsa drug interaction may still occur even if administration times are adjusted. Proton pump inhibitors PPIs should be withheld or avoided in patients requiring oral itraconazole therapy. Ivacaftor: Use caution when administering ivacaftor and lansoprazole concurrently. Ivacaftor is an inhibitor of CYP3A and P-glycoprotein Pgp. Ketoconazole: Ketoconazole requires an acidic pH for absorption.
Medications that increase gastric pH or decrease acid output can cause a notable decrease in the bioavailability of ketoconazole. Medications that have this effect are antacids, antimuscarinics, histamine H2-blockers, and proton pump inhibitors PPIs.
What should I avoid while taking Prevacid?
Low incidence of side effects have been reported during clinical trials of Lansoprazole Generic Prevacidincluding headache, diarrhoea, abdominal pain, dyspepsia, nausea, vomiting, dry mouth, constipation, flatulence, dizziness, fatigue rash, urticaria and pruritus.
These are not all the possible side effects of this medicine. For more information, ask your doctor. This medicine may affect how other medicines work, and other medicines may affect how this medicine works.
Animal reproduction studies have revealed no evidence of impaired fertility or harm to the fetus due to Lansoprazole. Because animal reproduction studies are not always predictive of human response, Generic Prevacid should be used during pregnancy only if clearly needed. It is not known whether Lansoprazole is excreted in human milk.
Prevacid side effects
I had been taking prevacid for two weeks prior to the EGD due to the trouble swallowing NOW i want to stop taking the prevacid and every time i try i get really sick. I get weak, nauseaus and for a day or two i literally go to the bathroom constantly and have loose yellow stools with stomach cramps. Read More I hope you dont mind if I share with you some things that I have experienced with my Hiatal hernia.
Read More Phlory or somethign like that and he called back and said my hernia was small no sugery need and gave me pills for the gastrits but recently i've been having bad back pain around my right side in the middle of the shoulder blades and in my right shoulder blade.
My nausea is getting worse. Read More He did a scope on her esaphagus and showed no permanent damage but did find a hiatal hernia. She would awaken to vomit in her bed. Read More This is response to chronic discomfort pain, nausea, and spasm just below the sternum.
Common Prevacid ide effects may include:
Unless your doctor tells you otherwise, continue your normal diet.
A search of the prescribing information for Prevacid shows that increased blood levels of potassium or hyperkalemia can occur with Prevacid.
Lori Mendoza, PharmD Poulin, PharmDQ: I take Prevacid daily, following my doctor's instructions.
The nonerosive GERD patients received PREVACID 15 mg daily for eight weeks and the EE patients received PREVACID 30 mg daily for eight to 12 weeks.
This risk is further increased if you are at risk of developing osteoporosis. If you have osteoporosis or have risk factors for developing osteoporosis, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Pregnancy: There are no adequate or well-controlled studies on the use of this medication by pregnant women.
Where can I get more information?
Talk to your doctor or pharmacist about whether taking a supplement is recommended or if you have any questions or concerns.
As recommended by the American College of Gastroenterology, the treatment to get rid of H.