Generic Name: Generic pletal
What is Generic Pletal?
Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. Cilostazol is a medication for the treatment of intermittent claudication, a condition caused by narrowing of the arteries that supply the legs with blood. Patients with intermittent claudication develop pain when they walk because not enough oxygen-containing blood reaches the active leg muscles. Cilostazol reduces the pain of intermittent claudication by dilating the arteries, thereby improving the flow of blood and oxygen to the legs.
It does this by decreasing the action of an enzyme, phosphodiesterase III. It also reduces the ability of blood to clot.
Cilostazol enables patients with intermittent claudication to walk longer and faster before developing pain. The FDA approved cilostazol in January 1999. What brand names are available for cilostazol. Is cilostazol available as a generic drug.
Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from PLETAL, discontinue nursing or discontinue PLETAL. No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be excluded.
Pharmacokinetic studies have not disclosed any age-related effects on the absorption, distribution, metabolism, and elimination of cilostazol and its metabolites. No dose adjustment is required in patients with mild hepatic impairment. No dose adjustment is required in patients with renal impairment. Information on acute overdosage with PLETAL in humans is limited. The signs and symptoms of an acute overdose can be anticipated to be those of excessive pharmacologic effect: severe headache, diarrhea, hypotension, tachycardia, and possibly cardiac arrhythmias.
The patient should be carefully observed and given supportive treatment. Since cilostazol is highly protein-bound, it is unlikely that it can be efficiently removed by hemodialysis or peritoneal dialysis. The oral LD50 of cilostazol is greater than 5 g per kg in mice and rats and greater than 2 g per kg in dogs. PLETAL and several of its metabolites inhibit phosphodiesterase III activity and suppress cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation, respectively.
PLETAL reversibly inhibits platelet aggregation induced by a variety of stimuli, including thrombin, ADP, collagen, arachidonic acid, epinephrine, and shear stress. In humans, heart rate increased in a dose-proportional manner by a mean of 5. Cilostazol's effects on platelet aggregation were evaluated in both healthy subjects and in patients with stable symptoms of cerebral thrombosis, cerebral embolism, transient ischemic attack, or cerebral arteriosclerosis over a range of doses from 50 mg every day to 100 mg three times a day.
How should I take Generic Pletal?
Methylsulfonylmethane, MSM: Increased effects from concomitant anticoagulant drugs including increased bruising or blood in the stool have been reported in patients taking methylsulfonylmethane, MSM.
If use together is medically necessary, use the lowest dose of cilostazol necessary e. Side effects of cilostazol may include unusual bleeding or bruising, diarrhea, dizziness, edema such as swelling of the ankles or legsheadache, or upset stomach. Milnacipran: Platelet aggregation may be impaired by serotonin norepinephrine reuptake inhibitors SNRIs due to platelet serotonin depletion, possibly increasing the risk of a bleeding complication e.
Mitotane: Use caution if mitotane and cilostazol are used concomitantly, and monitor for decreased efficacy of cilostazol and a possible change in dosage requirements. Mycophenolate: Platelet Inhibitors inhibit platelet aggregation and should be used cautiously in patients with thrombocytopenia, as mycophenolate can also cause thrombocytopenia.
What should I avoid while taking Generic Pletal?
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Generic Pletal side effects
You should not do both. How should I take PLETAL. Take PLETAL exactly as your doctor tells you to take it. Your doctor will tell you how much PLETAL to take and when to take it. Your doctor may change your dose if needed.
Common Generic Pletal ide effects may include:
Also, torsades de pointes TdP and ventricular tachycardia have been reported with anagrelide.
Patients receiving treatment with cilostazol should continue with their life-style modifications smoking cessation and exerciseand pharmacological interventions such as lipid lowering and antiplatelet treatment to reduce the risk of cardiovascular events.
The PBAC noted that the submission meets the criteria for an independent review.
Before taking Pletal, tell your doctor about all of your medical conditions.
Re-evaluting life maintenance plan with Jeri Reid, Internal Environmentalist working with doctors to eliminate some medications if possible. There was some discussion about a bypass.
In an effort to forestall that, the cardiologist prescribed Pletal. All of my doctors--GP, nephrologist, podiatrist, even the cardiologist--thought it wouldn't do anything.
Where can I get more information?
About us Contact Us facebook Google plus Twitter Online pharmacy reviews HomeDrug Facts And ComparisonsPharmacy ReviewBlogContact UsAbout us Cilostazol Pletal Generic Names : Cilostazol Brand Names : Pleta Cilostazol Pletal is a drug prescribed to improve walking distance and speed in patients with intermittent claudication.
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