Generic Name: Paxil

What is Paxil?

Pregnancy Patients should be advised to notify their physician if they become pregnant or intend to become pregnant during therapy see WARNINGS: Usage in Pregnancy: Teratogenic Effects and Nonteratogenic Effects. Laboratory Tests There are no specific laboratory tests recommended.

Mutagenesis Paroxetine produced no genotoxic effects in a battery of 5 in vitro and 2 in vivo assays that included the following: Bacterial mutation assay, mouse lymphoma mutation assay, unscheduled DNA synthesis assay, and tests for cytogenetic aberrations in vivo in mouse bone marrow and in vitro in human lymphocytes and in a dominant lethal test in rats.

Impairment Of Fertility Some clinical studies have shown that SSRIs including paroxetine may affect sperm quality during SSRI treatment, which may affect fertility in some men.

Pregnancy Pregnancy Category D. Labor And Delivery The effect of paroxetine on labor and delivery in humans is unknown. Nursing Mothers Like many other drugs, paroxetine is secreted in human milk, and caution should be exercised when PAXIL is administered to a nursing woman. Pediatric Use Safety and effectiveness in the pediatric population have not been established see BOX WARNING and WARNINGS: Clinical Worsening and Suicide Risk. Other Clinical Pharmacology Information Specific Populations Renal and Liver Disease: Increased plasma concentrations of paroxetine occur in subjects with renal and hepatic impairment.

Drug-Drug Interactions In vitro drug interaction studies reveal that paroxetine inhibits CYP2D6. Clinical Trials Major Depressive Disorder The efficacy of PAXIL as a treatment for major depressive disorder has been established in 6 placebo-controlled studies of patients with major depressive disorder aged 18 to 73.

Also, because fibromyalgia and anxiety are often diagnosed together, Paxil can provide some relief from the anxiety. Fibromyalgia and depression also often go together, so an SSRI antidepressant like Paxil can provide relief for fibromyalgia depression.

Because stressful life events can cause fibromyalgia flares, which in turn can cause anxiety, which then turns into a vicious cycle of anxiety and pain, SSRIs like Paxil can help prevent flares. You may find yourself better able to cope with day-to-day stressors and anxiety that could in turn lead to fibro flares. It also common for people who are unable to go about their daily activities of living to become depressed.

Not being able to care for your children, or go to a job can have a debilitating effect on your life, and an antidepressant like Paxil can help manage the depressed feelings. Many fibro patients develop anxiety about leaving the house, for fear of having a fibro flare while away from home.

Medicines like Paxil can help reduce those feeling of anxiety and help return to a more normal daily routine. Finally, seek immediate medial attention if you experience black or bloody stools, vomit that looks like coffee grounds, blurred vision, eye pain, swelling or redness of the eyes, widened pupils, or vision changes.

Paxil is only available by prescription, so you need to speak with a medical provider who is able to write them. Lupus Erythematosus and Fibromyalgia What is Psoriatic Arthritis.

Paxil Paroxetine is used to treat depression and is a group of drugs called selective serotonin reuptake inhibitors SSRIs. It is also used to treat social anxiety disorders, obsessive compulsive disorder OCDpanic disorder, and post traumatic stress disorder PTSD.

How should I take Paxil?

I am willing to try other methods of controlling it rather than take a drug with such terrible withdrawal symptoms. I wish all of you good luck. One thing that seems to be becoming more and more known is the relationship between the mind and the gut on this disorder and the fact that there is actually a nervous system in the gut itself that is almost independent of the brain.

I have had a very good response to SSRIs Paxil in my case at low doses that is even better than Imodium, Bentyl and other drugs, and even helps in combination with these. I've had success at one time or another with antibiotics, antifungals, calcium supplements, dietary control very important and just light exercise and stress reduction, but SSRIs at various doses have helped me a lot more especially in times when my situation is almost unbearable. Treatment using SSRIs for IBS is only in its infancy and a lot of doctors don't know how to prescribe SSRIs for IBS or even which drug is appropriate at what dose generally it is a much lower dose than that used for anxiety and depression.

I was shocked when my gastroenterologist said he didn't use them in treating IBS, whereas psychiatrists are much more aware of the benefits and do prescribe them for IBS sufferers even though you would think IBS is only marginally related to their field. I strongly recommend that sufferers, especially those who have constant bowel movements, investigate this with their physician or by searching the literature and consider a course of treatment just to see how it goes.

What should I avoid while taking Paxil?

Class C drugs have shown that they have adverse side effects on test animals that receive large dosage levels. Paxil, however, is a Class D medication.

Studies in humans and other investigations have shown a link between Paxil and other Class D drugs and an increased risk of congenital impairment or mutation. Paxil is the only drug in the SSRI category proven to cause birth defects. Regardless, some physicians will advise pregnant women to keep taking Paxil if they think the benefits will outweigh the risks.

Pregnant women also face serious health risks when taking Paxil while pregnant. In a recent study published in the Canadian Medical Association Journal, several researchers from the University of Montreal and other Canadian hospitals studied over 60,000 women who took SSRI medications while pregnant.

Paxil side effects

Treatment with Paxil and any concomitant serotonergic agents should be discontinued immediately if the above events occur and supportive symptomatic treatment should be initiated.

Thioridazine administration alone produces prolongation of the QTc interval, which is associated with serious ventricular arrhythmias, such as torsade de pointes-type arrhythmias, and sudden death. This effect appears to be dose related. An in vivo study suggests that drugs which inhibit CYP2D6, such as paroxetine, will elevate plasma levels of thioridazine.

Epidemiological studies have shown that infants exposed to paroxetine in the first trimester of pregnancy have an increased risk of congenital malformations, particularly cardiovascular malformations. The findings from these studies are summarized below:Other studies have found varying results as to whether there was an increased risk of overall, cardiovascular, or specific congenital malformations.

It was not possible in this meta-analysis to determine the extent to which the observed prevalence of cardiovascular malformations might have contributed to that of overall malformations, nor was it possible to determine whether any specific types of cardiovascular malformations might have contributed to the observed prevalence of all cardiovascular malformations.

Common Paxil ide effects may include:

  • PAXIL is indicated for the treatment of Posttraumatic Stress Disorder PTSD.

  • Do not drink alcohol while using PAXIL.

  • My anxiety started to manifest itself with uncontrollable crying.

  • How much of this drug is typically used.

To report any unexpected adverse or serious events associated with the use of this drug, please contact the FDA MedWatch program either online, by regular mail or by fax, using the contact information at the bottom of this sheet.

ConsiderationsPhysicians should consider the benefits and risks of treating pregnant women with SSRIs, alternative treatments, or no treatment late in pregnancy. Data SummaryA retrospective case-control study published on February 9, 2006, in the New England Journal of Medicine assessed the risk for persistent pulmonary hypertension of the newborn PPHN following exposure to SSRIs during pregnancy.

Exposure to non-SSRI antidepressants did not appear to be associated with an increased risk of PPHN, although the number of infants with exposure to non-SSRI antidepressants was too small to permit a reliable risk estimate or comparison with the risk observed for SSRIs.

Where can I get more information?

  • Warfarin: Caution is advised during concurrent use of warfarin with paroxetine.

  • Other medical problems-The presence of other medical problems may affect the use of paroxetine.