Generic Name: Oxsoralen
What is Oxsoralen?
Do not use this medication if you have active melanoma or a history of melanoma or invasive squamous cell carcinomas. If you have basal cell carcinoma, your doctor will monitor you closely for any signs that your cancer is getting worse while you take this drug. This medication is broken down by your liver.
Your doctor will monitor you closely if you take this drug. Talk with your doctor about whether this treatment will work for you. They will need to decide if you can stand for long periods of time, or handle the heat stress caused by UVA therapy. This drug should be used only if the potential benefit justifies the potential risk to the fetus.
Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication. Talk with your doctor about whether this drug is safe for you. If you have a history of cataracts, heart conditions, kidney or liver problems, or skin cancer, ask about any problems that this drug might cause. The safety of methoxsalen oral capsules has not been established in children.
You must remain under the care of a doctor while taking methoxsalen. You should not use methoxsalen if you have a condition that makes you more sensitive to light lupus, porphyria, albinism, and othersor if you have a history of skin cancer or damage to the lenses of your eyes due to surgery, injury, or genetic condition.
If your doctor changes your brand, strength, or type of methoxsalen, your dosage needs and UVA light therapy schedule may change. Oxsoralen-Ultra and 8-Mop are not equivalent medicines and may not have the same dose or schedule. Ask your pharmacist if you have any questions about the new kind of methoxsalen you receive at the pharmacy.
You should not use this medicine if you are allergic to methoxsalen or similar "psoralen" medicines, or if you have:Before your UVA treatment: Do not expose your skin to sunlight for at least 24 hours before you take methoxsalen. Avoid applying sunscreen to areas of psoriasis that will be treated with UVA therapy. Do not take this medicine in larger or smaller amounts or for longer than recommended. You will take methoxsalen a certain number of hours before you are scheduled to receive UVA treatment.
The soft gelatin capsule Oxsoralen-Ultra is more easily absorbed in the body than the hard gelatin capsule 8-Mop. The timing of your dose will depend on which type of capsule you are taking.
You may also need to keep taking methoxsalen after your UVA treatment, either for a short time or as needed. Follow your doctor's dosing instructions very carefully. Methoxsalen will make your skin more sensitive to sunlight and sunburn may result, which could interfere with your psoriasis treatment.
Wear protective clothing and use sunscreen SPF 30 or higher when you are outdoors or near a window.
How should I take Oxsoralen?
Some products that may interact with this drug include: other medications that may make your skin sensitive to light such as anthralin, coal tar, griseofulvin, sulfa antibiotics like sulfamethoxazole, fluoroquinolone antibiotics like ciprofloxacin, thiazide diuretics like hydrochlorothiazide, tetracycline antibiotics like doxycycline. This document does not contain all possible drug interactions. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious medication problems.
What should I avoid while taking Oxsoralen?
Download DRUG LABEL INFO: PDF XML Official Label Printer Friendly View All SectionsClose All Sections Methoxsalen with UV radiation should be used only by physicians who have special competence in the diagnosis and treatment of psoriasis and who have special training and experience in photochemotherapy. Close Oxsoralen-Ultra methoxsalen capsules, USP contains 10 mg. The structural formula is: The combination treatment regimen of psoralen P and ultraviolet radiation of 320-400 nm wavelength commonly referred to as UVA is known by the acronym, PUVA.
Close Photochemotherapy Methoxsalen with long wave UVA radiation is indicated for the symptomatic control of severe, recalcitrant, disabling psoriasis not adequately responsive to other forms of therapy and when the diagnosis has been supported by biopsy. Unless affected by disease, male genitalia should be shielded.
Oxsoralen side effects
Never dispense methoxsalen lotion to a patient. Methoxsalen is contraindicated for use by patients with an idiosyncratic reaction to psoralen compounds or with conditions associated with skin photosensitivity disorder because the drug increases photosensitivity potential.
Such conditions include systemic lupus erythematosus SLEporphyria cutanea tarda, erythropoietic protoporphyria EPPvariegate porphyria, xeroderma pigmentosum, albinism, hydroa vacciniforme, leukoderma of infectious origin, and polymorphous light eruption. Methoxsalen is contraindicated in patients with a history of melanoma, current melanoma, or invasive cutaneous squamous cell carcinoma because the drug can act as a photocarcinogen. Methoxsalen can potentiate the incidence of skin cancer or premature aging of the skin.
Common Oxsoralen ide effects may include:
Caution is recommended if interferon gamma-1b is used concurrently with myelosuppressive agents.
Because of the cataractogenic potential of psoralens and PUVA therapy, extreme caution should be exercised when using PUVA therapy in patients with cataracts.
Is methoxsalen-topical available as a generic drug.
Tell your doctor or prescriber about all prescription, over-the-counter non-prescriptionand herbal medications you are taking.
How much do you know about sex, love, and the human body. Marks, MD Jay W. Psoriasis Slideshow: Symptoms, Causes and Treatment Psoriasis Quiz: Test Your Medical IQ Moderate to Severe Forms of Psoriasis Slideshow What is methoxsalen-topical, and how does it work mechanism of action.
Where can I get more information?
Clevidipine: Preclinical data suggest that calcium-channel blockers could decrease the efficacy of photosensitizing agents used in photodynamic therapy.
Psoriasis: If the patient develops new areas of psoriasis during maintenance therapy but still is classified as having a Grade 4 responsethe exposure to UVA may be increased by 0.