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PUVA treatment, just like ultraviolet light in sunlight, can have cumulative effects on the skin and eyes. Long-term exposure to PUVA therapy can result in skin cancer of the same types caused by chronic exposure to sunlight. Certain patients are at greatest risk:Several studies in laboratory animals have shown that PUVA therapy, just like ultraviolet light from sunlight, can cause cataracts. This potential problem is completely avoidable by wearing correct eye protection during therapy.

The following precautions must be taken by all patients:Shielding of the eyes on the day of treatment is an absolute requirement. Protective glasses are available from the nurse. Exposure to sunlight causes freckling of the skin and in susceptible individuals, PUVA-treatment will also produce freckles.

Freckles are small flat brown spots on the skin which usually fade after treatment has stopped but subsequent exposure to sunlight tends to re-activate them. The use of PUVA therapy has not been associated with any abnormalities during pregnancy or in children born of mothers who received PUVA therapy inadvertently while pregnant.

However, the modern use of PUVA treatment resulted from two important developments. First, pure psoralen was isolated from plants in 1947 and this permitted the use of precise doses of the medication. The pure psoralen was introduced in the USA in 1952 for treatment of a skin disorder called vitiligo and in combination with sunlight, it was a moderately successful treatment.

The second major advance was the development of a high-intensity source of UVA radiation at Harvard in 1974. This permitted giving short and precise doses of UVA light so that sunlight, an unpredictable and unreliable source of UVA light, has been almost entirely eliminated in modern PUVA treatment. Development of a precise form of PUVA treatment resulted in an explosion of interest in determining how the treatment works and what disorders of the skin might benefit from the therapy.

Several thousand articles have now been published in the scientific literature as a result of study of these questions in many centers throughout the world. All the answers are not yet know but PUVA therapy is beneficial in more than twenty different diseases and it appears to act via at least two different mechanisms:A number of skin disorders appear to be produced by cells from the immune defense system of the body.

These cells are either multiplying too rapidly or behaving in an abnormal manner. PUVA treatment selectively kills off these cells and, fortunately, it can do this without producing any clinical evidence of harm to our normal immunity. Psoriasis, eczema, lichen planus, alopecia and mycosis fungoides are a few of the diseases that appear to respond to PUVA therapy via this mechanism.

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But the disfigurement of vitiligo, accentuated among persons with brown or black skin, can be devastating. The recent media publicity about Michael Jackson's battle with vitiligo has helped raise public awareness of the disease.

While vitiligo is worldwide and affects all races equally, it is a particularly troubling social problem for persons whose normal skin color is brown or black. The contrast between brown skin and white vitiligo spots can create a grotesque "harlequin" appearance.

The same kind of disfigurement can become a problem for vitiligo victims with normally fair skin who tan deeply during the summer months or, among those who live in sunny climates, throughout the year.

In India, vitiligo, or "leukoderma" as it is called there, is regarded as "white leprosy. A woman in India cannot marry if she has even one spot of vitiligo, and if a woman develops vitiligo after marriage it is considered grounds for divorce. It is no wonder vitiligo patients can turn aggressive, feel a sense of shame, or become withdrawn and resentful.

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Short hair is obviously one answer. Hair bands and bobby pins should be used to hold hair off the face and neck. Scales on the skin tends to block UVA light from penetrating. Try to remove as much scale as possible before each treatment by soaking or applying an emollient. Regular, punctual treatments are the key to success with PUVA therapy.

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Methoxsalen with UV radiation should be used only by physicians who have special competence in the diagnosis and treatment of psoriasis and who have special training and experience in photochemotherapy. The use of Psoralen and ultraviolet radiation therapy should be under constant supervision of such a physician. For the treatment of patients with psoriasis, photochemotherapy should be restricted to patients with severe, recalcitrant, disabling psoriasis which is not adequately responsive to other forms of therapy, and only when the diagnosis is certain.

Because of the possibilities of ocular damage, aging of the skin, and skin cancer including melanomathe patient should be fully informed by the physician of the risks inherent in this therapy. This new dosage form of methoxsalen exhibits significantly greater bioavailability and earlier photosensitization onset time than previous methoxsalen dosage forms. Patients should be treated in accordance with the dosimetry specifically recommended for this product.

Common Buy Oxsoralen ide effects may include:

  • If a flare occurs less than 6 weeks after the last treatment, 25 percent of the maximum exposure received during the clearing phase, with the clearing schedule received during the clearing phase, may be used and then proceed with the clearing schedule previously followed for this patient.

  • The exact mechanism of action of methoxsalen is not known.

  • Apixaban: Agents, such as anticoagulants, that decrease clotting could decrease the efficacy of photosensitizing agents used in photodynamic therapy.

  • Psoriasis is a skin condition associated with red and scaly patches.

Skin reactivity to UVA 320-400 nm radiation is markedly enhanced by the ingestion of methoxsalen. In a well controlled bioavailability study, Oxsoralen-Ultra Capsules reached peak drug levels in the blood of test subjects between 0.

Peak drug levels were 2 to 3 fold greater when the overall extent of drug absorption was approximately two fold greater for Oxsoralen-Ultra Capsules as compared to regular Oxsoralen Capsules. Detectable methoxsalen levels were observed up to 12 hours post dose.

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  • Methoxsalen can cause harmful effects on your vision and on your skin premature aging or skin cancer.

  • Potential hazards of long-term therapy include the possibilities of carcinogenicity and cataractogenicity as described in the Warnings Section as well as the probability of actinic degeneration which is also described in the Warnings Section.