Generic Name: Norvir
What is Norvir?
There are several protease inhibitors that treat HIV infection, for example: Drug interactions, dosage, preparations, and pregnancy and breastfeeding safety should be reviewed prior to taking these drugs. MedicineNet does not provide medical advice, diagnosis or treatment.
What is the dosage for ritonavir. Which drugs or supplements interact with ritonavir. Is ritonavir safe to take if I'm pregnant or breastfeeding. What else should I know about ritonavir. NorvirIs ritonavir available as a generic drug.
GENERIC AVAILABLE: No Do I need a prescription for ritonavir. Yes What are the side effects of ritonavir. The most serious side effects are: liver failure, inflammation of the pancreas pancreatitisheart block, and severe allergic reactions. Other important side effects include: diarrhea, nausea and vomiting, taste disturbance, abnormal skin sensations burning, prickling and tinglingheadache, weakness, and insomnia difficulty sleeping.
Trazodone is a CYP3A4 substrate and co-administration of ritonavir is expected to increase trazodone levels. Adverse reactions of nausea, dizziness, hypotension and syncope have been observed in single dose interaction studies in healthy volunteers see section 4. The concomitant use of ritonavir is not recommended due to potential increase in riociguat exposure see section 4.
The concomitant use of ritonavir is not recommended due to potential increase in vorapaxar exposure see section 4. Strong CYP3A4 inhibitors such as protease inhibitors may increase bedaquiline exposure which could potentially increase the risk of bedaquiline-related adverse reactions. Therefore, combination of bedaquiline with ritonavir should be avoided. However, if the benefit outweighs the risk, co-administration of bedaquiline with ritonavir must be done with caution. More frequent electrocardiogram monitoring and monitoring of transaminases is recommended see section 4.
Co-administration of delamanid with a strong inhibitor of CYP3A ritonavir may increase exposure to delamanid metabolite, which has been associated with QTc prolongation.
Therefore, if co-administration of delamanid with ritonavir is considered necessary, very frequent ECG monitoring throughout the full delamanid treatment period is recommended see section 4. The interaction profiles of HIV-protease inhibitors, co-administered with low dose ritonavir, are dependant on the specific co-administered protease inhibitor. For a description of the mechanisms and potential mechanisms contributing to the interaction profile of the PIs, see section 4.
How should I take Norvir?
Keep a list of your medicines to show our healthcare provider and pharmacist. See the detailed Instructions for Use for information about how to give or take a dose of NORVIR oral powder. Go to the nearest emergency room right away if this happens. These are not all of the possible side effects of NORVIR. Medicines are sometimes prescribed for purposes other than those listed in a Patient Information Leaflet.
What should I avoid while taking Norvir?
Ritonavir levels may increase on stopping St John's wort. The dose of ritonavir may need adjusting. The inducing effect may persist for at least 2 weeks after cessation of treatment with St John's wort see section 4. Serum levels of ritonavir may be affected by select co-administered medicinal products e. These interactions are noted in the medicinal product interaction tables below.
Interactions between ritonavir and protease inhibitors, antiretroviral agents other than protease inhibitors and other non-antiretroviral medicinal products are listed in the tables below. Medicinal Product Interactions - Ritonavir with Protease Inhibitors Ritonavir increases the serum levels of amprenavir as a result of CYP3A4 inhibition.
Clinical trials confirmed the safety and efficacy of 600 mg amprenavir twice daily with ritonavir 100 mg twice daily.
Norvir side effects
Ritonavir dosed as a pharmacokinetic enhancer or as an antiretroviral agent induces glucuronidation and as a result is expected to decrease the plasma concentrations of atovaquone. No interaction study is available with ritonavir only.
Clarithromycin14-OH clarithromycin metabolite Due to the large therapeutic window of clarithromycin no dose reduction should be necessary in patients with normal renal function. Ritonavir dosed as a pharmacokinetic enhancer or as an antiretroviral agent inhibits CYP3A4 and as a result is expected to increase the plasma concentrations of erythromycin and itraconazole. Ritonavir inhibits CYP3A-mediated metabolism of ketoconazole. Ritonavir dosed as an antiretroviral agent is likely to inhibit CYP2D6 and as a result is expected to increase concentrations of haloperidol, risperidone and thioridazine.
Due to CYP3A inhibition by ritonavir, concentrations of lurasidone are expected to increase.
Common Norvir ide effects may include:
Initiation of medications that inhibit or induce CYP3A may increase or decrease concentrations of NORVIR, respectively.
For example, ritonavir-boosted indinavir Crixivan is taken twice daily with food, whereas indinavir alone must be taken three times a day on an empty stomach.
In MT4 cells, ritonavir demonstrated additive effects against HIV-1 in combination with either didanosine ddI or zidovudine ZDV.
Loss of therapeutic effect of NORVIR and possible development of resistance.
Serious problems can occur if you or your child takes any of these medicines with NORVIR. What should I tell my doctor before taking NORVIR. Tell your doctor right away if you are taking: Estrogen-based contraceptives birth control. You should use a different type or an extra form of birth control, since estrogen-based contraceptives may not work as well while you take NORVIR.
Where can I get more information?
After the clinical benefit of NORVIR therapy was demonstrated, all patients were eligible to switch to open-label NORVIR for the duration of the follow-up period.
ContinuePRINTSee the complete prescribing information for fosamprenavir, atazanavir, darunavir for details on co-administration with ritonavir.