Generic Name: Nitrostat
What is Nitrostat?
Nimodipine, Acting related to calcium channel receptors of the blood vessels of the brain, has a protective effect on nerve cells, stabilizes their function, improves brain blood circulation, improves the ischemic tolerance of nerve cells, it does not develop "steal syndrome".
In patients with impaired liver function due to lower intensity of the primary metabolism and slowing down the metabolic inactivation of the bioavailability of nimodipine can increase. Consequently, the main and side effects, in particular its hypotensive effect may be intensified.
In such cases, the drug dose must be reduced depending on the degree of decrease in blood pressure, and should be discontinued if necessary reception nimodipine. Nimodipine may lower blood pressure in a joint appointment with diuretics, beta-blockers, ACE inhibitors, antagonists of A1 adenosine receptors, other calcium channel blockers, alpha-blockers, alpha-methyldopa, phosphodiesterase inhibitors.
Prolonged use of nimodipine with the antidepressant nortriptyline resulted in a slight decrease in nimodipine plasma concentrations nortriptyline concentration remains unchanged.
Since nimodipine is metabolized with participation of cytochrome P450 3A4, drugs inhibiting this enzyme system may increase the concentration of nimodipine plasma. These are drugs likeThe joint appointment of such drugs should be provided for the reduction of the dose of nimodipine and monitoring blood pressure.
Grapefruit juice inhibits the oxidative metabolism of dihydropyridine. Combinations of grapefruit juice and avoid nimodipine, t. This may lead to increased concentrations of nimodipine in blood plasma.
Prior to taking this medicine, it is important to be consulted by a doctor. This is an essential part of the process, as it will help determine whether you are a suitable candidate for this medicine. With this in mind, during your consultation, make sure to let your doctor know what other health conditions you are currently suffering from, but also if you have any allergies, or are undergoing any sort of medical treatment, as there can be several interactions with Nimotop.
What should patients know when it comes down to correctly following their treatment. There are also times when patients are unable to swallow the pills orally.
If this is the case, then the medicine will be given via an IV, or nasogastric tube, as your doctor instructs. Here are the most common side effects associated with Nimotop and what should patients do in the unfortunate case that they overdose. Some of the main side effects include itching, gastrointestinal pain, vomiting, headaches, and more. Do keep in mind that the medicine can provoke a worsening of the side effects, just like an overdose would do as well.
If this is the case, seek emergency medical attention. Published on 2017-04-29 08:18:20People who are suffering from insomnia and other sleeping problems need help now, they do not have the time to go through long term treatments.
How should I take Nitrostat?
Azithromycin, although structurally related to the class of macrolide antibiotics, is void of CYP3A4 inhibition. The simultaneous administration of nimodipine with the anticonvulsant valproic acid or the H2-antagonist cimetidine can lead to an increase in the plasma concentration of nimodipine see section 4.
Effects of nimodipine on other drugs Animal studies have shown that when nimodipine and zidovudine are administered concomitantly, the AUC for zidovudine was increased, and the volume of distribution and clearance rate decreased.
The clinical relevance of this interaction is unknown, but since the side-effects profile of zidovudine is known to be dose-related, this interaction should be considered in patients receiving nimodipine and zidovudine concomitantly.
Other types of interaction Blood pressure lowering drugs Nimodipine may increase the blood pressure lowering effect of concomitant antihypertensives, such as:- diuretics, - beta-blockers, - ACE inhibitors, - A1-antagonists, - other calcium antagonists, - alpha-adrenergic blocking agents, - PDE5 inhibitors- alpha-methyldopa.
However, if a combination of this type proves unavoidable particularly careful monitoring of the patient is necessary.
What should I avoid while taking Nitrostat?
In a letter dated July 30, 2010, Bayer HealthCare Pharmaceuticals Inc. Currently, there are three approved ANDAs for nimodipine capsules, 30 mg. Lachman Consultant Services, Inc. In the Petition, the petitioner identified no data or other information suggesting that NIMOTOP Nimodipine Capsules, 30 mg, was withdrawn for reasons of safety or effectiveness.
In responding to the Petition, we have carefully reviewed our files for records concerning the withdrawal of NIMOTOP Nimodipine Capsules, 30 mg.
Nitrostat side effects
The dosage recommendations and duration of treatment is dependent upon your condition, and will be determined by your doctor. If you miss one or more doses of NIMOTOP tablets, DO NOT TAKE A DOUBLE DOSE. If while undergoing treatment with NIMOTOP you experience any side-effects or symptoms which may be due to this medication whether or not it is mentioned below please inform your Doctor or Pharmacist immediately.
Some patients may experience unwanted effects when taking this medication. Uncommon side effects may affect up to 1 in 100 people include dizziness, lightheadedness, nausea, vomiting, allergic reaction, rash, itching, fluid retention,headache, reddening of the face or sweating, thrombocytopaenia decrease in number of platelets in blood.
Ask your doctor, nurse or pharmacist to answer any questions you may have. When treatment is to be stopped, your prescribing doctor may need to alter the dose of other medication accordingly and monitor your conditionNIMOTOP infusion solution is sensitive to light and should not be exposed to direct sunlight.
Infusion tubes and pumps should be protected from light with coverings, or coloured tubing may be used.
Common Nitrostat ide effects may include:
This drug may make you dizzy.
This type of medicine acts on the blood vessels.
Quantity Limits Drugs that have quantity limits associated with each prescription.
This type of medicine acts on the blood vessels.
The additional perfusion usually more pronounced in damaged before enough blood perfused brain. The use of nimodipine can significantly reduce the mortality and incidence of subarachnoid hemorrhage occurs due to ischemic neurological disorders.
Nimodipine, Acting related to calcium channel receptors of the blood vessels of the brain, has a protective effect on nerve cells, stabilizes their function, improves brain blood circulation, improves the ischemic tolerance of nerve cells, it does not develop "steal syndrome". In patients with impaired liver function due to lower intensity of the primary metabolism and slowing down the metabolic inactivation of the bioavailability of nimodipine can increase.
Consequently, the main and side effects, in particular its hypotensive effect may be intensified.
Where can I get more information?
Side effects other than those listed here may also occur.
In the event of Nimotop tablets and solution for infusion being administered sequentially, the total duration of treatment should not exceed 21 days.