Generic Name: Mysoline
What is Mysoline?
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Megaloblastic anemia may occur as a rare idiosyncrasy to Mysoline and to other anticonvulsants. The abrupt withdrawal of antiepileptic medication may precipitate status epilepticus. The therapeutic efficacy of a dosage regimen takes several weeks before it can be assessed.
Antiepileptic drugs AEDSincluding Mysoline, increase the risk of suicidal thoughts or behavior in patients taking these drugs for any indication. Pooled analyses of 199 placebo-controlled clinical trials mono- and adjunctive therapy of 11 different AEDs showed that patients randomized to one of the AEDs had approximately twice the risk adjusted Relative Risk 1.
In these trials, which had a median treatment duration of 12 weeks, the estimated incidence rate of suicidal behavior or ideation among 27,863 AED-treated patients was 0. There were four suicides in drug-treated patients in the trials and none in placebo-treated patients, but the number is too small to allow any conclusion about drug effect on suicide.
The increased risk of suicidal thoughts or behavior with AEDs was observed as early as one week after starting drug treatment with AEDs and persisted for the duration of treatment assessed. Because most trials included in the analysis did not extend beyond 24 weeks, the risk of suicidal thoughts or behavior beyond 24 weeks could not be assessed.
The risk of suicidal thoughts or behavior was generally consistent among drugs in the data analyzed. The finding of increased risk with AEDs of varying mechanisms of action and across a range of indications suggests that the risk applies to all AEDs used for any indication. The risk did not vary substantially by age 5-100 years in the clinical trials analyzed. Anyone considering prescribing Mysoline or any other AED must balance the risk of suicidal thoughts or behavior with the risk of untreated illness.
Epilepsy and many other illnesses for which AEDs are prescribed are themselves associated with morbidity and mortality and an increased risk of suicidal thoughts and behavior. Should suicidal thoughts and behavior emerge during treatment, the prescriber needs to consider whether the emergence of these symptoms in any given patient may be related to the illness being treated.
How should I take Mysoline?
Report Problems to the Food and Drug Administration You are encouraged to report negative side effects of prescription drugs to the FDA. Suicidal Behavior And Ideation Antiepileptic drugs AEDSincluding Mysoline, increase the risk of suicidal thoughts or behavior in patients taking these drugs for any indication. Table 1 shows absolute and relative risk by indication for all evaluated AEDs.
Usage In Pregnancy To provide information regarding the effects of in utero exposure to Mysoline, physicians are advised to recommend that pregnant patients taking Mysoline enroll in the North American Antiepileptic Drug NAAED Pregnancy Registry. The effects of Mysoline in human pregnancy and nursing infants are unknown. In Nursing Mothers There is evidence in mothers treated with primidone, the drug appears in the milk in substantial quantities.
What should I avoid while taking Mysoline?
The risk or severity of adverse effects can be increased when Primidone is combined with Thiamylal. The risk or severity of adverse effects can be increased when Primidone is combined with Thiopental. The serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Primidone resulting in a loss in efficacy.
The risk or severity of adverse effects can be increased when Tolcapone is combined with Primidone. The risk or severity of adverse effects can be increased when Topiramate is combined with Primidone.
Mysoline side effects
Neither Everyday Health nor its licensor assume any responsibility for any aspect of healthcare administered with the aid of the information provided. If you have any questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
If you would like to obtain more information about these advertising practices and to make choices about online behavioral advertising, please click here. Register Now Email or Username Password Remember me Forgot your password. Ask your doctor or pharmacist for more information. These are not all the possible side effects of Mysoline. This medication comes in tablet form and is taken one to three times a day, with or without food.
Common Mysoline ide effects may include:
Spinocerebellar Ataxia Spinocerebellar ataxia SCA is a progressive, neurodegenerative, genetic disease, which has no cure and treated only symptomatically.
Do not start, stop, or change the dosage of any medicines without your doctor's approval.
However, if it is almost time for your next dose, then skip the missed dose and go back to your regular dosing schedule.
Tell your doctor if you are taking any drugs that may add to primidone's drowsiness effects such as: narcotic pain medicines e.
MYSOLINE doesn't buy mysoline. If your MYSOLINE is suffering from mental retardation and takes an anticonvulsant medication MYSOLINE is especially bothersome.
MYSOLINE possesses no acidic properties, in contrast to its anticonvulsant activity, Mysoline potentiates that of phenobarbital in experimental animals.
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Where can I get more information?
The risk or severity of adverse effects can be increased when Primidone is combined with gabapentin enacarbil.
Do I need a prescription for primidone-oral.