Generic Name: Lopid
What is Lopid?
If you notice any signs of infection e. Gallbladder disease: This medication may increase the risk for gallstones. If you have a history of gallbladder disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Liver function: Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects.
If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Your doctor may want to test your liver function regularly with blood tests while you are taking this medication. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.
If you are taking gemfibrozil and one of these medications, discuss with your doctor how this medication may affect your medical condition, and whether any special monitoring is needed. If you experience symptoms of muscle breakdown, such as generalized weakness, muscle pain, a general feeling of being unwell, with or without fever, contact your doctor immediately.
Pregnancy: Strict birth control methods must be used by women who may become pregnant while taking this medication. If you become pregnant despite using birth control, stop taking gemfibrozil and contact your doctor.
Maternal toxicity was observed in both species and the clinical relevance of decreases in rabbit litter size and rat pup weight is uncertain. For the full list of excipients, see section 6. Primary prevention Reduction of cardiovascular morbidity in males with increased non-HDL cholesterol and at high risk for a first cardiovascular event when a statin is contraindicated or not tolerated see section 5.
Prior to initiating gemfibrozil, other medical problems such as hypothyroidism and diabetes mellitus must be controlled as best as possible and patients should be placed on a standard lipid-lowering diet, which should be continued during treatment. Lopid should be taken orally. Posology Adult The dose range is 900 mg to 1200 mg daily.
The only dose with documented effect on morbidity is 1200 mg daily. The 1200 mg dose is taken as 600 mg twice daily, half an hour before breakfast and half an hour before the evening meal. The 900 mg dose is taken as a single dose half an hour before the evening meal.
Elderly over 65 years old As for adults Children and adolescents Gemfibrozil therapy has not been investigated in children. Due to the lack of data the use of Lopid in children is not recommended.
Lopid should not be used in patients with severely impaired renal function see section 4. Hepatic impairment Gemfibrozil is contraindicated in hepatic impairment see section 4. There have been reports of severe myositis with markedly elevated creatine kinase and myoglobinuria rhabdomyolysis when gemfibrozil and HMG CoA reductase inhibitors were used concomitantly see sections 4.
Pharmacokinetic interactions may also be present see also section 4.
How should I take Lopid?
Please remove another drug before adding this one.
What should I avoid while taking Lopid?
The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine.
Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome. Important: if you develop any muscle aches or pains, particularly in your legs, you should tell your doctor about it. This is a rare, but potentially serious, side-effect of treatment.
If you experience any other symptoms which you think may be due to the medicine, speak with your doctor or pharmacist for further advice. Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital.
Lopid side effects
High cholesterol and triglyceride levels increase the risk of cardiovascular disease. Getting your cholesterol and triglyceride levels in an optimal range will help protect your heart and blood vessels. Cholesterol management may include lifestyle interventions diet and exercise as well as medications to get your total cholesterol, LDL, HDL, and triglycerides in an optimal range.
Cholesterol carried in particles of low density LDL cholesterol is referred to as the "bad" cholesterol because elevated levels of LDL cholesterol are associated with an increased risk of coronary heart disease. See a picture of Cholesterol and learn more about the health topic. A cholesterol blood test measures the amount of cholesterol in the body. High cholesterol levels in the blood can lead to heart attack, stroke, and peripheral vascular disease.
Common Lopid ide effects may include:
Take this medication by mouth as directed by your doctor, usually twice a day 30 minutes before your morning and evening meals.
The primary event of non-fatal myocardial infarction or cardiac death occurred in 17.
Hoe wordt Lopid ingenomen 4.
CYP2C8 plays a minor role in the metabolism of apixaban, and gemfibrozil is a strong CYP2C8 inhibitor.
The concomitant administration of gemfibrozil with these anticoagulants necessitates careful monitoring of prothrombin time INR - International Normalised Ratio.
Caution should be exercised when such a coumarin type vitamin K antagonist anticoagulant is given concomitantly with gemfibrozil. The dosage of the anticoagulant may need to be reduced to maintain desired prothrombin time levels see section 4.
Where can I get more information?
Anyone with kidney or liver problems should probably not take Lopid.
If you are a breast-feeding mother and are taking this medication, it may affect your baby.