Generic Name: Lipitor
What is Lipitor?
Could Lipitor have caused this and shouldn't I have been warned of the side effects. I have tried several other cholesterol lowering drugs, but have had muscle aching. I started taking Lipitor and after about 3 weeks, experienced joint pain and some muscle pain. After going off of it, I still have joint pain, in knees and hip area.
Could the Lipitor be aggravating the joints. Answer: Not usually the joints, muscle inflammation yes-but, you should see an increase in a lab test called CPK.
Answer: Usually very few. Some patients experience GI symptoms and there can be elevation of liver enzymes-these need to be checked by blood tests so that the medication can be stopped if they rise while taking the medication. Will they raise my cholesterol level. What about effects on my liver.
Answer:The only way to know is to start them and check your levels closely.
Atherosclerosis is a chronic process and discontinuation of lipid-lowering drugs during pregnancy should have little impact on the outcome of long-term therapy of primary hypercholesterolemia.
In rat and rabbit animal reproduction studies, atorvastatin revealed no evidence of teratogenicity. LIPITOR is a selective, competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl-coenzyme A to mevalonate, a precursor of sterols, including cholesterol. Cholesterol and triglycerides circulate in the bloodstream as part of lipoprotein complexes. With ultracentrifugation, these complexes separate into HDL high-density lipoproteinIDL intermediate-density lipoproteinLDL low-density lipoproteinand VLDL very-low-density lipoprotein fractions.
Triglycerides TG and cholesterol in the liver are incorporated into VLDL and released into the plasma for delivery to peripheral tissues. LDL is formed from VLDL and is catabolized primarily through the high-affinity LDL receptor.
Clinical and pathologic studies show that elevated plasma levels of total cholesterol total-CLDL-cholesterol LDL-Cand apolipoprotein B apo B promote human atherosclerosis and are risk factors for developing cardiovascular disease, while increased levels of HDL-C are associated with a decreased cardiovascular risk.
LIPITOR reduces LDL-C in some patients with homozygous familial hypercholesterolemia FHa population that rarely responds to other lipid-lowering medication s. LIPITOR reduces total-C, LDL-C, and apo B in patients with homozygous and heterozygous FH, nonfamilial forms of hypercholesterolemia, and mixed dyslipidemia. LIPITOR also reduces VLDL-C and TG and produces variable increases in HDL-C and apolipoprotein A-1.
LIPITOR reduces total-C, LDL-C, VLDL-C, apo B, TG, and non-HDL-C, and increases HDL-C in patients with isolated hypertriglyceridemia.
How should I take Lipitor?
Lipitor and other statins are commonly used to treat dyslipidemia and to prevent cardiovascular disease CVD in people who are at high risk. If a person has dyslipidemia, or hyperlipidemia, they have a high level of cholesterol, triglycerides, or both, in the blood. According to the Centers for Disease Control and Prevention CDCin 2011 to 2012, nearly 28 percent of adults aged 40 years and over were using some kind of prescription drug to lower cholesterol.
This was an increase of nearly 8 percent since 2003. Of these, 1 in 5 were using atorvastatin. Lipitor belongs to a class of drugs called HMG CoA reductase inhibitors, commonly known as statins. Other statins include fluvastatin, pravastatin, rosuvastatin, and simvastatin.
What should I avoid while taking Lipitor?
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Lipitor side effects
It doesn't seem to be drug specific. I'm not sure if it relates to changes in estrogen metabolism in the liver or direct effects of the drug. In both cases, we had to stop the drug. Diarrhea seems a little more common with lipitor than others of this class at least at the 20 mg dosage. Answer: No data here but studies in progress.
Common Lipitor ide effects may include:
A stroke is an interruption of the blood supply to part of the brain caused by either a blood clot ischemic or bleeding hemorrhagic.
Lipitor tablets contains lactose.
In the Reversing Atherosclerosis with Aggressive Lipid- Lowering Study REVERSALthe effect of intensive lipid lowering with atorvastatin 80 mg and standard degree of lipid lowering with pravastatin 40 mg on coronary atherosclerosis was assessed by intravascular ultrasound IVUSduring angiography, in patients with coronary heart disease.
I just read that 10 mgs is a high dose.
Each daily dose of atorvastatin is given all at once and may be given at any time of day with or without food. Patients who develop any signs or symptoms suggestive of liver injury should have liver function tests performed.
Patients who develop increased transaminase levels should be monitored until the abnormality ies resolve. Should an increase in transaminases of greater than 3 times the upper limit of normal ULN persist, reduction of dose or withdrawal of Lipitor is recommended see section 4.
Where can I get more information?
They contend that Pfizer failed to adequately warn physicians and consumers of the risk of developing type 2 diabetes from taking Lipitor and that the company knew or should have known that the risks of Lipitor included developing diabetes.
So, I'd need to know your LDL.