Generic Name: Lanoxin

What is Lanoxin?

Ask your doctor if you have any questions about why LANOXIN has been prescribed for you. Your doctor may have prescribed LANOXIN for another reason. If you are not sure whether you should start taking LANOXIN, talk to your doctor or pharmacist. Tell your doctor if you are pregnant or intend to become pregnant. Pregnant women may require an adjustment of the dose of LANOXIN during pregnancy. This medicine may have harmful effects on the developing baby if the dose is too high. If you have not told your doctor or pharmacist about any of the above, it is important to tell them before you start taking LANOXIN.

Tell your doctor or pharmacist if you are taking any other medicines, including any that you buy without a prescription from your pharmacy, supermarket or health food shop.

Some medicines and LANOXIN may interfere with each other. These medicines may be affected by LANOXIN or may affect how well it works.

Cardiac toxicity accounts for about one-half, gastrointestinal disturbances for about one-fourth, and CNS and other toxicity for about one-fourth of these adverse events.

Thrombocytopenia and maculopapular rash and other skin reactions have been rarely observed. Digoxin has a narrow therapeutic index, increased monitoring of serum digoxin concentrations and for potential signs and symptoms of clinical toxicity is necessary when initiating, adjusting, or discontinuing drugs that may interact with digoxin. Prescribers should consult the prescribing information of any drug which is co-prescribed with digoxin for potential drug interaction information.

Digoxin is a substrate of P-glycoprotein. Drugs that induce or inhibit P-glycoprotein in intestine or kidney have the potential to alter digoxin pharmacokinetics. Continue monitoring and reduce digoxin dose as necessary.

Digoxin concentrations decreased Acarbose, activated charcoal, albuterol, antacids, certain cancer chemotherapy or radiation therapy, cholestyramine, colestipol, extenatide, kaolin-pectin, meals high in bran, metoclopramide, miglitol, neomycin, penicillamine, phenytoin, rifampin, St.

John's Wort, sucralfate, sulfasalazine Measure serum digoxin concentrations before initiating concomitant drugs.

No significant Digoxin exposure changes Please refer to section 12 for a complete list of drugs which were studies but reported no significant changes on digoxin exposure. No additional actions are required. Drugs that Affect Renal Function Caution should be exercised when combining digoxin with any drug that may cause significant deterioration in renal function e.

Parathyroid Hormone Analog Teriparatide Sporadic case reports have suggested that hypercalcemia may predispose patients to digitalis toxicity.

How should I take Lanoxin?

Administering digoxin to a patient with thyroid disease requires care. Initial and maintenance doses of digoxin should be reduced when thyroid function is subnormal. In hyperthyroidism there is relative digoxin resistance and the dose may have to be increased. During the course of treatment of thyrotoxicosis, dosage should be reduced as the thyrotoxicosis comes under control. Patients with malabsorption syndrome or gastro-intestinal reconstructions may require larger doses of digoxin.

Although many patients with chronic congestive cardiac failure benefit from acute administration of digoxin, there are some in whom it does not lead to constant, marked or lasting haemodynamic improvement.

What should I avoid while taking Lanoxin?

Distribution The initial distribution of digoxin from the central to the peripheral compartment generally lasts from 6 to 8 h. Biotransformation The majority of digoxin is excreted by the kidneys as an intact drug, although a small fraction of the dose is metabolised to pharmacologically active and inactive metabolites. Elimination The major route of elimination is renal excretion of the unchanged drug. Special patient populations Paediatric population In the newborn period, renal clearance of digoxin is diminished and suitable dosage adjustments must be observed.

Renal impairment The terminal elimination half-life of digoxin is prolonged in patients with impaired renal function, and in anuric patients may be of the order of 100 h.

Contents of the pack and other informationLanoxin Tablets contains the active substance digoxin, which belongs to a group of medicines called cardiac glycosides.

It is used to treat arrhythmias and heart failure. An arrhythmia is an irregularity in the heart-beat, which causes the heart to skip a beat, beat irregularly or beat at the wrong speed.

Lanoxin side effects

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How to use LanoxinTake this medication by mouth with or without food, usually once daily or as directed by your doctor. Tell your doctor if your condition does not improve or if it worsens.

Common Lanoxin ide effects may include:

  • For brands that may still be available, search under digoxin.

  • You will either: take one large single dose and then begin your maintenance dose or take a smaller dose each day for a week and then begin your maintenance dose.

  • Serum digoxin concentration may decrease acutely during periods of exercise without any associated change in clinical efficacy due to increased binding of digoxin to skeletal muscle.

  • Diagnosis and treatment of chest pain depends upon the cause and clinical presentation of the patient's chest pain.

Once you have achieved the appropriate loading dose of Lanoxin you will continue to take the maintenance dose usually daily for as long as recommended by your doctor, which may be for the rest of your life depending on your condition and what you are being treated for. How long should you take Lanoxin. Missed dose of Lanoxin If you miss a dose of Lanoxin tablets 250mcg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.

More about Lanoxin

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Where can I get more information?

  • In a small study, plasma digoxin concentration profiles in patients with acute hepatitis generally fell within the range of profiles in a group of healthy subjects.

  • Tell your doctor or pharmacist if you are taking any other medicines, including any that you buy without a prescription from your pharmacy, supermarket or health food shop.