Lamictal

Generic Name: Lamictal

What is Lamictal?

Most commonly, this drug is used to treat patients with epilepsy in order to reduce the frequency of seizures. In addition, Lamictal is also used to treat seizures for patients with Lennox-Gastaut syndrome. Lamictal is generally associated with treatment for epilepsy and other related seizures. However, Lamictal is also use to treat some mood problems in patients who are experiencing bipolar disorder. Due to the breadth of use, Lamictal presents a variety of dangers to those who have taken the medication.

Please be aware that a number of patients who were on the medication for less a month still experienced quite a few side effects. Regardless of the length of time you were on Lamictal, you may experience the following side effects in addition to double vision:Lamictal patients have reported experiencing all of the above symptoms.

If you or a loved one has begun to feel any adverse side effects following the use of Lamictal, you must seek medical attention immediately. Following your doctor visit, contact a dangerous drug attorney from Eichholz Law Firm to discuss your possible options. Double vision was a late side effect linked to Lamictal, however, recent research and studies have indicated that double vision is an incredibly common side effect that must be taken seriously.

Pooled analyses of 199 placebo-controlled clinical trials monotherapy and adjunctive therapy of 11 different AEDs showed that patients randomized to 1 of the AEDs had approximately twice the risk adjusted Relative Risk 1. In these trials, which had a median treatment duration of 12 weeks, the estimated incidence of suicidal behavior or ideation among 27,863 AED-treated patients was 0.

There were 4 suicides in drug-treated patients in the trials and none in placebo-treated patients, but the number of events is too small to allow any conclusion about drug effect on suicide.

The increased risk of suicidal thoughts or behavior with AEDs was observed as early as 1 week after starting treatment with AEDs and persisted for the duration of treatment assessed. Because most trials included in the analysis did not extend beyond 24 weeks, the risk of suicidal thoughts or behavior beyond 24 weeks could not be assessed.

Anyone considering prescribing Lamictal or any other AED must balance the risk of suicidal thoughts or behavior with the risk of untreated illness. Epilepsy and many other illnesses for which AEDs are prescribed are themselves associated with morbidity and mortality and an increased risk of suicidal thoughts and behavior.

Should suicidal thoughts and behavior emerge during treatment, the prescriber needs to consider whether the emergence of these symptoms in any given patient may be related to the illness being treated. Patients, their caregivers, and families should be informed that AEDs increase the risk of suicidal thoughts and behavior and should be advised of the need to be alert for the emergence or worsening of the signs and symptoms of depression, any unusual changes in mood or behavior, the emergence of suicidal thoughts or suicidal behavior, or thoughts about self-harm.

Behaviors of concern should be reported immediately to healthcare providers. Therapy with Lamictal increases the risk of developing aseptic meningitis. Because of the potential for serious outcomes of untreated meningitis due to other causes, patients should also be evaluated for other causes of meningitis and treated as appropriate. Postmarketing cases of aseptic meningitis have been reported in pediatric and adult patients taking Lamictal for various indications. Symptoms upon presentation have included headache, fever, nausea, vomiting, and nuchal rigidity.

How should I take Lamictal?

Lamotrigine levels may be decreased by oral contraceptives and increased when they are stopped if monotherapy: adjust doseand may affect hormonal replacement therapy or other hormonal contraceptive efficacy. Register below for a customized experience and free access to premium resources.

Company: GlaxoSmithKline Mood disorders Seizure disorders Indications for LAMICTAL: Maintenance treatment of bipolar I disorder to delay the time to occurrence of mood episodes depression, mania, hypomania, mixed episodes in patients treated for acute mood episodes with standard therapy. Limitations Of use: Not recommended for treatment of acute manic or mixed episodes. Additional factors that may increase risk of rash include concurrent use with valproate, exceeding lamotrigine recommended initial dose, or exceeding lamotrigine recommended dosage escalation.

Discontinue drug at first sign of rash, unless rash is clearly not drug-related. Thought to block sodium channel membranes, which in turn inhibits release of the neurotransmitters glutamate and aspartate in brain.

Usual maintenance dose starting week 8 and onward is 400 to 600 mg every day.

What should I avoid while taking Lamictal?

However, in worldwide postmarketing experience, rare cases of rash-related death have been reported, but their numbers are too few to permit a precise estimate of the rate. There is evidence that the inclusion of valproate in a multidrug regimen increases the risk of serious, potentially life-threatening rash in adults.

This disorder is variable in its expression, and other organ systems not noted here may be involved. Fatalities associated with acute multiorgan failure and various degrees of hepatic failure have been reported in 2 of 3,796 adult patients and 4 of 2,435 pediatric patients who received Lamictal in epilepsy clinical trials. Rare fatalities from multiorgan failure have also been reported in postmarketing use.

Isolated liver failure without rash or involvement of other organs has also been reported with Lamictal.

Lamictal side effects

I added this note just so that I could link an interesting article on volunteers who took lamotrigine and experienced a reduction in anxiety while public speaking. The medication decreased the cortisol response to this stress. Sagud The authors did a good job tracking other variables that might have influenced their findings. As of early 2016, according to a study that just came out, people taking lamotrigine should not take folate in any formbecause the folate might make the lamotrigine no better than a placebo.

For details of that study, see my separate page summarizing its findings.

Common Lamictal ide effects may include:

  • If any side effects become bothersome or affect your daily activities you should consult with your physician.

  • In patients receiving concomitant therapy with phenytoin, carbamazepine, pheonbarbitone or primidone, the appropriate treatment regimen should be used see section 4.

  • It is not known if Lamictal is safe or effective for people with mood episodes who have not already been treated with other medicines.

  • Lamotrigine can pass into breast milk and may harm a nursing baby.

If a little extra such as one or two extra tablets is taken by accident, call the doctor for advice. For a larger overdose, call a poison control center or emergency room right away unless you have other specific directions from your doctor. To avoid unwanted side effects, the doctor will prescribe a low dose to start and increase it gradually until seizures are controlled. The amount the doctor will prescribe will depend on what other seizure medicines are taken.

Most people need to take Lamictal twice a day, but some need to take it only once a day.

Where can I get more information?

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  • Pramipexole: Coadministration of pramipexole and lamotrigine may decrease pramipexole clearance, resulting in increased plasma concentrations and the potential for adverse events, including dizziness, mental status changes, and abnormal movements.