Generic Name: Isordil sublingual
What is Isordil Sublingual?
For sublingual dosage form tablets :Adults-2. Missed DoseTOP If you miss a dose of this medicine, take it as soon as possible. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Before UsingTOP In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do.
For this medicine, the following should be considered: AllergiesTOP Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines.
PediatricTOP Appropriate studies have not been performed on the relationship of age to the effects of isosorbide dinitrate in the pediatric population. GeriatricTOP Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of isosorbide dinitrate in the elderly. PregnancyTOP Pregnancy CategoryExplanationAll TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.
Breast FeedingTOP There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Drug InteractionsTOP Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur.
Prevention of angina pectoris Dosage 5-40 mg Oral, tablets given every six hours To provide a nitrate-free interval and minimize the likelihood of tolerance, it might be administered 2-3 times daily with the last dose at approximately 7 p. Prevention of angina pectoris Dosage 40-80 mg Oral, extended release tablets given every 8-12 hours To provide a nitrate-free interval and minimize the likelihood of tolerance, it might be administered twice daily at 8 a.
Contraindications Isosorbide dinitrate is contraindicated in those known to be hypersensitive to organic nitrates. Adverse Effects Adverse effects associated with the use of isosorbide dinitrate include headache, dizziness, nausea, vomiting, hypotension, and rash McEvoy 2004.
Agent-Agent Interactions Agent Name Mode of Interaction Sildenafil Sildenafil inhibits phosphodiesterase type 5, the enzyme responsible for the metabolic degradation of cyclic GM P.
Organic nitrates activate guanylate cyclase, which increases cyclic GM P. The combination of sildenafil and isosorbide dinitrate may therefore produce excessive hypotension. Tadalafil Tadalafil inhibits phosphodiesterase type 5, the enzyme responsible for the metabolic degradation of cyclic GM P.
The combination of tadalafil and isosorbide dinitrate may therefore produce excessive hypotension. Vardenafil Vardenafil inhibits phosphodiesterase type 5, the enzyme responsible for the metabolic degradation of cyclic GM P.
The combination of vardenafil and isosorbide dinitrate may therefore produce excessive hypotension. Alcohol and other vasodilators Alcohol and other vasodilators may intensify the hypotensive effects of isosorbide dinitrate.
Disopyramide Because disopyramide decreases salivary secretions it inhibits the absorption of sublingually administered isosorbide dinitrate. Read full chapter Chapter:Guanylyl Cyclase, Soluble Andreas Friebe Doris Koesling, in xPharm: The Comprehensive Pharmacology Reference, 2007.
How should I take Isordil Sublingual?
The metabolism of nitroprusside results in the formation of cyanide, which then reacts with cytochrome C, inhibiting aerobic metabolism and causing lactic acidosis. Read full chapter Chapter:Achalasia and Other Motor Disorders Manu R.
Rudolph, in Pediatric Gastrointestinal and Liver Disease Fourth Edition2011. Disorders of the Distal Esophagus Esophageal Achalasia Treatment Drug Therapy Isosorbide dinitrate, a smooth muscle relaxant, decreases LES pressure and improves esophageal emptying in achalasia.
DRUGS IN CLINICAL USE ORAL AGENTS Isosorbide Isosorbide Ismotic, Hydronol is a dihydric alcohol formed by the removal of two molecules of water from sorbitol. Its time of onset and duration of action are similar to those of glycerol.
What should I avoid while taking Isordil Sublingual?
Prophylactic acetaminophen can reduce the problems associated with nitrate-induced headache, whereas NSAIDs should be avoided. Several long-acting nitrate preparations are now available, but the clinical experience with these formulations in patients with HF is limited.
Coronary therapeutic drugs cardiac vasodilators The nitrates isosorbide mononitrate, isosorbide dinitrate, nitroglycerine or glyceryl trinitrate, and pentaerithritol tetranitrate have been approved for the treatment of angina pectoris and, in some cases, of myocardial infarction.
They are also used for other indications: for biliary colics, as a tocolytic agent in obstetrics e. A study to assess cervix length and the presence of cervical gland area in ultrasounds performed before and after the administration of vaginal isosorbide mononitrate for cervical ripening in pregnancy indicated for labor induction had to be discontinued due to adverse effects, such as nausea, dizziness, dyspnea, and vomiting Hatanaka 2012. Experiences with use in the first trimester are limited.
Few relevant studies cover other coronary drugs such as ivabradine, molsidomine, ranolazine, and trapidil. Trapidil was compared to a placebo in a study of 180 women with a higher risk of preeclampsia between weeks 22 and 38 according to Dodd 2010.
Isordil Sublingual side effects
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:This section provides information on the proper use of a number of products that contain isosorbide dinitrate.
It may not be specific to Isordil.
Common Isordil Sublingual ide effects may include:
Large controlled studies with other nitrates suggest that no dosing regimen with Isordil Sublingual tablets should be expected to provide more than about 12 hours of continuous anti-anginal efficacy per day.
Rashes are one of the most common medical symptoms.
Do not use this medication without telling your doctor if you are breast-feeding a baby.
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Trapidil was compared to a placebo in a study of 180 women with a higher risk of preeclampsia between weeks 22 and 38 according to Dodd 2010. Specific side effects were not noted. Nitrates may be used in pregnancy provided they are used for the right indication.
Where can I get more information?
Treatment of angina pectoris Dosage 5 mg Oral, chewable tablets Use as an abortive agent should be reserved for those who are intolerant of or unresponsive to sublingual nitroglycerin.
Sit down before taking this medicine in case you get dizzy.