Generic Name: Imuran

What is Imuran?

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Follow up on it and don't let it go. My dose was very small and intended to complement Copaxone treatment, as I have several lesions on the spinal cord. My doctor said that the imunossupressants like imuran show some evidence at preventing more lesions on spinal cord. Krijgt u last van erge keelpijn in combinatie met koorts, vermoeidheid, regelmatig een bloedneus en snel blauwe plekken, neem dan direct contact op met uw arts.

De werkzame stof azathioprine zit in de volgende producten: Imuran Azathioprine Azafalk Azathioprine is sinds 1963 internationaal op de markt. Disclaimer Vind een apotheek Wilt u meer weten, of heeft u een vraag over uw eigen situatie. What Imuran Tablets are and what they are used for 2. What you need to know before you take Imuran Tablets 3.

Maintenance therapy should be at the lowest effective dose, and the dose given can be lowered decrementally with changes of 0. The optimum duration of maintenance IMURAN has not been determined.

IMURAN can be discontinued abruptly, but delayed effects are possible. Relatively oliguric patients, especially those with tubular necrosis in the immediate postcadaveric transplant period, may have delayed clearance of IMURAN or its metabolites, may be particularly sensitive to this drug, and are usually given lower doses.

Procedures for proper handling and disposal of this immunosuppressive antimetabolite drug should be considered. Revised: Feb 2014The principal and potentially serious toxic effects of IMURAN are hematologic and gastrointestinal.

The risks of secondary infection and malignancy are also significant see WARNINGS. The frequency and severity of adverse reactions depend on the dose and duration of IMURAN as well as on the patient's underlying disease or concomitant therapies. The incidence of hematologic toxicities and neoplasia encountered in groups of renal homograft recipients is significantly higher than that in studies employing IMURAN for rheumatoid arthritis.

The incidence of lymphoproliferative disease in patients with RA appears to be significantly higher than that in the general population. However, the proportion of the increased risk attributable to the azathioprine dosage or to other therapies i. Dose reduction or temporary withdrawal may result in reversal of these toxicities. Infection may occur as a secondary manifestation of bone marrow suppression or leukopenia, but the incidence of infection in renal homotransplantation is 30 to 60 times that in rheumatoid arthritis.

TPMT genotyping or phenotyping can help identify patients with low or absent TPMT activity homozygous for non-functional alleles who are at increased risk for severe, life-threatening myelosuppression from IMURAN. Death associated with pancytopenia has been reported in patients with absent TPMT activity receiving azathioprine.

How should I take Imuran?

After 3 years it lost it's effectiveness and I was put on Imuran. That lasted 3 weeks. Are my symptoms worsening. Are my symptoms improving. I'm no doctor, but if your symptoms are stable and you feel better, then something is helping.

What should I avoid while taking Imuran?

The interaction is well-documented i. The increase in azathioprine activity is due to the ability of allopurinol to inhibit xanthine oxidase-controlled metabolism, thereby decreasing the elimination of azathioprine. When possible, this drug combination should be avoided.

If avoidance of cotherapy is not possible, a reduced dosage of azathioprine e. Further azathioprine dosage reduction or use of an alternative therapy is recommended for patients who have low or absent thiopurine methyltransferase activity, as both the thiopurine methyltransferase and xanthine oxidase pathways are affected.

Alpha interferons: Additive myelosuppressive effects may be seen when alpha interferons are given concurrently with other myelosuppressive agents, such as antineoplastic agents or immunosuppressives. This combination should be avoided where possible.

Imuran side effects

After 3 years it lost it's effectiveness and I was put on Imuran. That lasted 3 weeks. Are my symptoms worsening. Are my symptoms improving. I'm no doctor, but if your symptoms are stable and you feel better, then something is helping.

Common Imuran ide effects may include:

  • Azathioprine therapy requires an experienced clinician who is familiar with the mutagenic potential and risk of hematological toxicities associated with the drug.

  • These include:Using this drug with azathioprine can decrease the amount of white blood cells in your body necessary to fight an infection.

  • Azathioprine is an imidazole derivative of 6-mercaptopurine 6-MP.

  • For this product there is no modern clinical documentation that can be used as support for determining the frequency of undesirable effects.

Use with Other Agents Affecting Myelopoesis: Drugs which may affect leukocyte production, including co-trimoxazole, may lead to exaggerated leukopenia, especially in renal transplant recipients.

Use with Angiotensin-Converting Enzyme Inhibitors: The use of angiotensin-converting enzyme inhibitors to control hypertension in patients on azathioprine has been reported to induce anemia and severe leukopenia.

Use with Warfarin: IMURAN may inhibit the anticoagulant effect of warfarin.

More about Imuran

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Where can I get more information?

  • Tell your doctor if any of these symptoms are severe or do not go away:Some side effects can be serious.

  • There is limited experience of the administration of Imuran to elderly patients.