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This may increase your risk of infections. These effects usually happen within the first few weeks after starting the medication. If your doctor stops the drug, your symptoms should go away. Azathioprine increases your risk of developing a low blood cell count, such as low white blood cell counts.
This drug may be used as part of a combination therapy. That means you may need to take it with other drugs. Azathioprine is used to treat rheumatoid arthritis RA and to keep your immune system from attacking a newly transplanted kidney. For RA, this keeps your immune system from attacking and damaging your joints.
Other drugs may interact with azathioprine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. This information does not replace the advice of a doctor.
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If you have had an organ transplant, it is recommended that you attend a transplant education class or support group. Learn the signs of organ rejection such as a feeling of being ill, fever, or tenderness around the transplanted organ.
Seek immediate medical attention if these symptoms occur. MISSED DOSE: Unless your doctor directs you otherwise, if you take this drug once daily and miss a dose, take it as soon as you remember unless it is almost time for the next dose.
If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.
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Warfarin Inhibition of the anticoagulant effect of warfarin, when administered with azathioprine, has been reported. Other interactions As there is in vitro evidence that aminosalicyclate derivatives eg. Vaccines The immunosuppressive activity of Imuran could result in an atypical and potentially deleterious response to live vaccines and so the administration of live vaccines to patients receiving Imuran therapy is contra-indicated on theoretical grounds.
Mutagenicity Chromosomal abnormalities, which disappear with time, have been demonstrated in lymphocytes from the offspring of patients treated with Imuran. Use in Pregnancy and Lactation Imuran should not be given to patients who are pregnant or likely to become pregnant without careful assessment of risk versus benefit.
Lactation 6-Mercaptopurine has been identified in the colostrum and breast-milk of women receiving azathioprine treatment. Infection and infestations Transplant patients receiving Imuran in combination with other immunosuppressants. Very common: Viral, fungal and bacterial infections.
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These medications are relatively safe during pregnancy but family planning should be discussed with the doctor for more information. Read more: Pregnancy and Crohn's Disease or Ulcerative ColitisYes, but it is important to consume in moderation as the combination of these drugs and alcohol can increase stress on the liver.
Read more: Other treatments for Crohn's or for colitisJoin our e-newsletter to keep updated with the Crohn's and colitis news and knowledge. Toggle navigation How It Works Articles Ulcerative Colitis Crohn's Disease Log In Home Crohn's Disease Treatments Imuran Azathioprine and 6-MP 6-Mercaptopurine What is it.
Why do I need this medication.
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This restriction typically requires that certain criteria be met prior to approval for the prescription.
Abatacept: Concomitant use of immunosuppressives may potentially increase the risk of serious infection in abatacept treated patients.
People using this medication may have serious side effects.
People who have previously been treated with an alkylating agent may have an excessive risk of cancers if treated with azathioprine.
This may be associated with symptoms of a hypersensitivity reaction see Hypersensitivity reactions. Rare, but life-threatening hepatic damage associated with chronic administration of azathioprine has been described primarily in transplant patients.
Histological findings include sinusoidal dilatation, peliosis hepatis, veno-occlusive disease and nodular regenerative hyperplasia.
Where can I get more information?
Trimethoprim: Azathioprine may interact with other drugs that are myelosuppressive.
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