Generic Name: Order hyzaar
What is Order Hyzaar?
Losartan pharmacokinetics have been investigated in the elderly 65-75 years and in both genders. Plasma concentrations of losartan and its active metabolite are similar in elderly and young hypertensives. Plasma concentrations of losartan were about twice as high in female hypertensives as male hypertensives, but concentrations of the active metabolite were similar in males and females.
Following oral administration in patients with mild to moderate alcoholic cirrhosis of the liver, plasma concentrations of losartan and its active metabolite were, respectively, 5 times and about 1.
The lower starting dose of losartan recommended for use in patients with hepatic impairment cannot be given using HYZAAR. No clinically significant drug interactions have been found in studies of losartan potassium with hydrochlorothiazide, digoxin, warfarin, cimetidine and phenobarbital. Conversion of losartan to its active metabolite after intravenous administration is not affected by ketoconazole, an inhibitor of P450 3A4.
The pharmacodynamic consequences of concomitant use of losartan and inhibitors of P450 2C9 have not been examined. Subjects who do not metabolize losartan to active metabolite have been shown to have a specific, rare defect in cytochrome P450 2C9.
These data suggest that the conversion of losartan to its active metabolite is mediated primarily by P450 2C9 and not P450 3A4. Reduction in the Risk of Stroke: The LIFE study was a multinational, double-blind study comparing losartan and atenolol in 9193 hypertensive patients with ECG-documented left ventricular hypertrophy.
Top Most Important Fact about Generic Hyzaar You must take Generic Hyzaar regularly for it to be effective. Top Why Generic Hyzaar should not be prescribed. Jump to navigation Do not use if you are pregnant. You should not use this medcine if you are unable to urinate, or if you are allergic to penicillin or sulfa drugs.
If you have diabetes, do not use hydrochlorothiazide and losartan together with any medication that contains aliskiren Amturnide, Tekturna, Tekamlo, Valturna.
Hydrochlorothiazide and losartan is a combination medicine used to treat high blood pressure hypertension. You should not use this medicine if you are allergic to hydrochlorothiazide or losartan, if you are unable to urinate. You may also need to avoid taking hydrochlorothiazide and losartan with aliskiren if you have kidney disease. Do not use if you are pregnant.
Hydrochlorothiazide and losartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.
If you need surgery, tell the surgeon ahead of time that you are using hydrochlorothiazide and losartan. If you are being treated for high blood pressure, keep using this medicine even if you feel well.
You may need to use blood pressure medicine for the rest of your life.
How should I take Order Hyzaar?
When you check your blood pressure, write down the measurements to show your health care professional. You must not get dehydrated. Avoid alcoholic drinks until you have discussed their use with your health care professional. If you are going to have surgery tell your health care professional that you are taking Generic Hyzaar. Generic Hyzaar may affect your blood sugar level. As diuretics cause your kidneys to produce more urine, you may prefer to take Generic Hyzaar in the morning rather than before going to bed, as this will reduce the likelihood of you needing to get up in the night to visit the toilet.
Seek further advice from your health care professional. Why Generic Hyzaar should not be prescribed.
What should I avoid while taking Order Hyzaar?
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Order Hyzaar side effects
Norepinephrine: Thiazide diuretics can cause decreased arterial responsiveness to norepinephrine, but the effect is not sufficient to preclude their coadministration. Octreotide: Patients receiving diuretics or other agents to control fluid and electrolyte balance may require dosage adjustments while receiving octreotide due to additive effects. Olanzapine: Olanzapine may induce orthostatic hypotension and thus enhance the effects of antihypertensive agents.
Olodaterol: Hypokalemia associated with thiazide diuretics can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded. Omeprazole: Proton pump inhibitors have been associated with hypomagnesemia.
Ondansetron: The coadministration of ondansetron with diuretics associated with hypokalemia could increase the risk of QT prolongation. Potassium levels should be within the normal range prior to and during therapy with ondansetron. Oxaprozin: Nonsteroidal anti-inflammatory drugs NSAIDs may reduce the natriuretic effect of diuretics in some patients.
Common Order Hyzaar ide effects may include:
This medication should not be taken by people with severely impaired kidney function.
Check with your doctor right away if you become sick while taking this medicine, especially if you have severe or continuing nausea or vomiting, or diarrhea that does not stop.
For stroke prophylaxis in hypertensive patients with left ventricular hypertrophy LVH.
NotesDo not share this medication with others.
Another study investigated the dose-response relationship of various doses of hydrochlorothiazide 6. The third study investigated the dose-response relationship of various doses of losartan 25, 50 and 100 mg or placebo on a background of hydrochlorothiazide 25 mg in patients not adequately controlled SiDBP 93-120 mmHg on hydrochlorothiazide 25 mg alone.
These studies showed an added antihypertensive response at trough 24 hours post-dosing of hydrochlorothiazide 12. Similarly, there was an added antihypertensive response at trough when losartan 50 or 100 mg was added to hydrochlorothiazide 25 mg of 9. There was no significant effect on heart rate.
Where can I get more information?
Treatment with clozapine has been associated with QT prolongation, torsade de pointes TdPcardiac arrest, and sudden death.
There was no difference in response for men and women or in patients over or under 65 years of age.