Generic Name: Hyzaar
What is Hyzaar?
Discontinuation of fluoxetine should be considered in patients who develop symptomatic hyponatremia. Inhibitors of the hepatic CYP2C9 isoenzyme, such as fluoxetine, have potential to inhibit the conversion of losartan to its active metabolite.
Patients receiving a diuretic during treatment with fluoxetine may be at greater risk of developing syndrome of inappropriate antidiuretic hormone secretion SIADH. Flurbiprofen: Nonsteroidal anti-inflammatory drugs NSAIDs may reduce the natriuretic effect of diuretics in some patients. Fluvoxamine: Patients receiving a diuretic during treatment with fluvoxamine may be at greater risk of developing syndrome of inappropriate antidiuretic hormone secretion SIADH. Discontinuation of fluvoxamine should be considered in patients who develop symptomatic hyponatremia.
Inhibitors of the hepatic CYP2C9 isoenzyme, such as fluvoxamine, have the potential to inhibit the conversion of losartan to its active metabolite. Formoterol: Hypokalemia associated with thiazide diuretics can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded. Fosinopril: Patients with hyponatremia or hypovolemia are more susceptible to developing reversible renal insufficiency when given angiotensin converting enzyme ACE inhibitors and diuretics concomitantly.
Fosphenytoin: In a study of 16 healthy volunteers, phenytoin inhibited the CYP2C9-mediated conversion of losartan to its active metabolite. A similar interaction might be expected with fosphenytoin.
Learn more about Medicare prescription drug plans and savings with GoodRx. All trademarks, brands, logos and copyright images are property of their respective owners and rights holders and are used solely to represent the products of these rights holders. This information is for informational purposes only and is not meant to be a substitute for professional medical advice, diagnosis or treatment. GoodRx is not offering advice, recommending or endorsing any specific prescription drug, pharmacy or other information on the site.
It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs including any herbal medicines or supplements or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.
Hyzaar is a combination of losartan Cozaar and hydrochlorothiazide and is used for treating high blood pressure. Losartan is an oral medication that belongs to a class of drugs called angiotensin receptor blockers ARBs. Other ARBs include irbesartan Avaprovalsartan Diovanand candesartan Atacand.
Angiotensin, formed in the blood by the action of angiotensin converting enzyme ACEis a powerful chemical that attaches to angiotensin receptors found in many tissues but primarily on smooth muscle cells surrounding blood vessels. Angiotensin's attachment to the receptors causes the muscles to contract and the blood vessels to narrow vasoconstrict which leads to an increase in blood pressure hypertension.
Losartan more specifically, the chemical formed when the liver converts the inactive losartan into an active chemical blocks the angiotensin receptor. By blocking the action of angiotensin, losartan relaxes the muscles, dilates blood vessels and thereby reduces blood pressure.
How should I take Hyzaar?
HCTZ should be used with caution in patients with hepatic disease since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.
Thiazide diuretics are not effective in this setting. Thiazide diuretics are generally not effective in this setting. Hyzaar:- Protect from light- Store at controlled room temperature between 68 and 77 degrees F Thiazide diuretics such as hydrochlorothiazide have been associated with a slight increase in serum cholesterol and triglyceride concentrations. Data from long-term studies, however, suggest diuretic-induced cholesterol changes are not clinically significant and do not contribute to coronary heart disease risk.
Thiazide diuretics are contraindicated in patients with known thiazide diuretic hypersensitivity. According to the manufacturer, hydrochlorothiazide is specifically contraindicated in patients with sulfonamide hypersensitivity.
Although thiazide diuretics are sulfonamide derivatives, sulfonamide cross-sensitivity has been rarely documented.
What should I avoid while taking Hyzaar?
When initiating therapy in these patients, lower doses are recommended. Orthostatic hypotension may occur during treatment with thiazide diuretics. Orthostatic hypotension can be exacerbated by concurrent use of alcohol, narcotics, or antihypertensive drugs. Excessive hypotension during thiazide diuretic therapy can result in syncope. An increased risk of falls has been reported for elderly patients receiving thiazide diuretics.
Hyzaar side effects
At least 61 percent of the oral dose is eliminated unchanged within 24 hours. Hydrochlorothiazide crosses the placental but not the blood-brain barrier and is excreted in breast milk. Losartan pharmacokinetics have been investigated in the elderly 65-75 years and in both genders. Plasma concentrations of losartan and its active metabolite are similar in elderly and young hypertensives. Plasma concentrations of losartan were about twice as high in female hypertensives as male hypertensives, but concentrations of the active metabolite were similar in males and females.
Following oral administration in patients with mild to moderate alcoholic cirrhosis of the liver, plasma concentrations of losartan and its active metabolite were, respectively, 5 times and about 1.
The lower starting dose of losartan recommended for use in patients with hepatic impairment cannot be given using HYZAAR.
Common Hyzaar ide effects may include:
Published on 2017-04-27 06:23:44In order for you to be safe while using Ambien, you need to make sure you always have someone you are able to talk to.
For a complete list, ask your doctor or pharmacist.
Tolvaptan: Monitor serum sodium closely if these drugs are used together.
You can ask your pharmacist or doctor for information that is written for health professionals.
Some patients will find when they decide to take extra action such as decreasing the amount of salty food they eat and exercising, along with drinking more water they can help in their cause. People who need serious help in order to lower their risk of certain health problems are best suited for this treatment. If you get prescribed Hyzaar, then what are some of the more common potential side effects you can end up suffering as a result.
Where can I get more information?
Losartan Cozaar belongs to a class of drugs referred to as ARBs angiotensin receptor blockers.
Her passion of biochemistry and research led her to pursue a career in pharmacy.