Generic Name: Hard on
What is Hard On?
Linezolid is not active against infections caused by Gram negative pathogens. Specific therapy against Gram negative organisms must be initiated concomitantly if a Gram negative pathogen is documented or suspected. Complicated skin and soft tissue infections see section 4. Linezolid should only be used in patients with complicated skin and soft tissue infections with known or possible co-infection with Gram negative organisms if there are no alternative treatment options available see section 4.
In these circumstances treatment against Gram negative organisms must be initiated concomitantly. Linezolid should only be initiated in a hospital environment and after consultation with a relevant specialist such as a microbiologist or infectious diseases specialist. Consideration should be given to official guidance on the appropriate use of antibacterial agents.
Many approaches are available for oxazolidinone synthesis, and several routes for the synthesis of linezolid have been reported in the chemistry literature.
Studies of the compounds' structure-activity relationships led to the development of several subclasses of oxazolidinone derivatives, with varying safety profiles and antimicrobial activity. Two compounds were considered drug candidates: eperezolid codenamed PNU-100592 and linezolid PNU-100766.
Food and Drug Administration FDA approved linezolid on April 18, 2000. Studies have been conducted in several countries with different health care system models to assess the cost-effectiveness of linezolid compared to glycopeptides such as vancomycin or teicoplanin. In most countries, linezolid was more cost-effective than comparable antibiotics for the treatment of hospital-acquired pneumonia and complicated skin and skin structure infections, either due to higher cure and survival rates or lower overall treatment costs.
Generics are also available, such as Lenzomore in India, by MorepenLinospan in India, by CiplaNezocin in Pakistan, by Brookesvoxazoldin in Egypt, by RotabiogenLizomed in India, as a dry syrup by Aglowmedand Linzolid in Bangladesh, by Incepta. Expert Opinion on Drug Safety.
Botanical Miracles: Chemistry of Plants That Changed the World. The evolution of drug discovery: From traditional medicines to modern drugs. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. To: By clicking send, you acknowledge that you have permission to email the recipient with this information.
View explanations for tiers and restrictions Tier Description 1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
How should I take Hard On?
Pediatric Patients The safety of ZYVOX formulations was evaluated in 215 pediatric patients ranging in age from birth through 11 years, and in 248 pediatric patients aged 5 through 17 years 146 of these 248 were age 5 through 11 and 102 were age 12 to 17.
Laboratory Abnormalities ZYVOX has been associated with thrombocytopenia when used in doses up to and including 600 mg every 12 hours for up to 28 days. Postmarketing Experience The following adverse reactions have been identified during postapproval use of ZYVOX. Adrenergic And Serotonergic Agents Linezolid has the potential for interaction with adrenergic and serotonergic agents. Report Problems to the Food and Drug Administration You are encouraged to report negative side effects of prescription drugs to the FDA.
Peripheral And Optic Neuropathy Peripheral and optic neuropathies have been reported in patients treated with ZYVOX, primarily in those patients treated for longer than the maximum recommended duration of 28 days.
Serotonin Syndrome Spontaneous reports of serotonin syndrome including fatal cases associated with the co-administration of ZYVOX and serotonergic agents, including antidepressants such as selective serotonin reuptake inhibitors SSRIshave been reported.
Clostridium Difficile Associated Diarrhea Clostridium difficile associated diarrhea CDAD has been reported with use of nearly all antibacterial agents, including ZYVOX, and may range in severity from mild diarrhea to fatal colitis.
What should I avoid while taking Hard On?
There were 79 patients randomized to high-dose linezolid and 66 to low-dose linezolid. The cure rate was higher in the high-dose arm than in the low-dose arm, although the difference was not statistically significant at the 0.
A safety and efficacy study provided experience on the use of ZYVOX in pediatric patients for the treatment of nosocomial pneumonia, complicated skin and skin structure infections, and other infections due to Gram-positive bacterial pathogens, including methicillin-resistant and -susceptible Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. Pediatric patients ranging in age from birth through 11 years with infections caused by the documented or suspected Gram-positive bacteria were enrolled in a randomized, open-label, comparator-controlled trial.
All patients were treated for a total of 10 to 28 days and could receive concomitant Gram-negative antibiotics if clinically indicated. In the intent-to-treat ITT population, there were 206 patients randomized to linezolid and 102 patients randomized to vancomycin. The cure rates for ITT, MITT, and clinically evaluable patients are presented in Table 18.
Hard On side effects
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Common Hard On ide effects may include:
You Can Only See One Thing Clearly, And That Is Your Goal.
Contact your physician or pharmacist.
There were 241 linezolid-treated and 120 comparator-treated patients in the intent-to-treat ITT study population.
ZYVOX is not indicated for the treatment of Gram-negative infections.
Linezolid is an antibiotic which is used for serious infections which are difficult to treat with other antibiotics. It is used to treat pneumonia, which is a serious lung infection. It is also used to treat skin and soft tissue infections caused by infection with MRSA bacteria.
Where can I get more information?
The drug's manufacturer, Pharmacia and Upjohn, expects Zyvox to be used mainly in hospitals or long-term care facilities, to lessen the chance that inappropriate use of the antibiotic would lead to an increase in resistant organisms.
Patients should be advised that: ZYVOX may be taken with or without food.