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As age of pediatric patients increases, the clearance of linezolid gradually decreases, and by adolescence, mean clearance values approach those observed for the adult population. There is wider inter-subject variability in linezolid clearance and in systemic drug exposure AUC across all pediatric age groups as compared with adults. Similar mean daily AUC values were observed in pediatric patients from birth to 11 years of age dosed q8h relative to adolescents or adults dosed q12h.
Pediatric patients 12 years and older should receive 600 mg q12h. Recommendations for the dosage regimen for pre-term neonates less than 7 days of age gestational age less than 34 weeks are based on pharmacokinetic data from 9 pre-term neonates.
Most of these pre-term neonates have lower systemic linezolid clearance values and larger AUC values than many full-term neonates and older infants. No overall differences in safety or effectiveness were observed between these patients and younger patients. The most common adverse events in patients treated with ZYVOX were diarrhea incidence across studies: 2.
Other adverse events reported in Phase 2 and Phase 3 studies included oral moniliasis, vaginal moniliasis, hypertension, dyspepsia, localized abdominal pain, pruritus, and tongue discoloration.
Mayo Clinic Health LetterMedical ProductsPopulation Health and Wellness ProgramsHealth Plan AdministrationMedical Laboratory ServicesContinuing Education for Medical ProfessionalsGive NowYour ImpactFrequently Asked QuestionsContact Us to GiveGive to Mayo ClinicHelp set a new world standard in care for people everywhere. Drugs and SupplementsLinezolid Oral Route Print Sections Description and Brand Names Before Using Proper Use Precautions Side Effects Products and services Free E-newsletter Subscribe to Housecall Our general interest e-newsletter keeps you up to date on a wide variety of health topics.
Sign up now Description and Brand NamesDrug information provided by: MicromedexUS Brand Name Zyvox DescriptionsLinezolid is used to treat certain bacterial infections in many different parts of the body, including certain types of skin infections or pneumonia.
Advertisement Mayo Clinic does not endorse companies or products. If a price is shown in red, GoodRx has found discount prices that are lower than your Medicare co-pay. It is used to treat certain kinds of bacterial infections.
It will not work for colds, flu, or other viral infections. Prescription Settings generic tablet 600mg 28 tablets Enter a custom quantity Set Save MyRx Drug Limit You can only add a maximum of 25 drugs to MyRx. Please remove another drug before adding this one. In general, Medicare plans do not cover this drug. This drug will likely be quite expensive and you may want to consider using a GoodRx discount instead of Medicare to find the best price for this prescription. How much is my linezolid co-pay with Medicare.
Which coverage stage are you in. Want an exact price for your co-pay. Select Your Plan Ways to Save on Zyvox Here are some ways that may lower the cost of your linezolid prescription.
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However, given the absence of information on the clinical significance of accumulation of the primary metabolites, use of linezolid in patients with renal insufficiency should be weighed against the potential risks of accumulation of these metabolites.
Both linezolid and the two metabolites are eliminated by dialysis. On the basis of the available information, no dose adjustment is recommended for patients with mild-to-moderate hepatic insufficiency. The pharmacokinetics of linezolid in patients with severe hepatic insufficiency have not been evaluated. It is not detectably metabolized by human cytochrome P450 and it does not inhibit the activities of clinically significant human CYP isoforms 1A2, 2C9, 2C19, 2D6, 2E1, 3A4.
The interaction studies conducted in normotensive subjects evaluated the blood pressure and heart rate effects of placebo, PPA or PSE alone, linezolid alone, and the combination of steady-state linezolid 600 mg q12h for 3 days with two doses of PPA 25 mg or PSE 60 mg given 4 hours apart.
Linezolid is a synthetic antibacterial agent of a new class of antibiotics, the oxazolidinones, which has clinical utility in the treatment of infections caused by aerobic Gram-positive bacteria.
Linezolid binds to a site on the bacterial 23S ribosomal RNA of the 50S subunit and prevents the formation of a functional 70S initiation complex, which is an essential component of the bacterial translation process.
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Linezolid "pros" and "cons" Advantages:Mode of action Linezolid has a unique structure and mechanism of action, which targets bacterial protein synthesis i. Linezolid is bacteriostatic against enterococci and staphylococci, and bactericidal for the majority of streptococci. Initially there were hopes that bacteria would be unable to develop resistance to linezolid. However, in 2003 Staphylococcus aureus was first identified as being resistant. Time to clear out of the system Linezolid half-life is 4-5.
Further reading Linezolid Zyvox versus. Linezolid vs Vancomycin References 1. Linezolid for the treatment of intractable multidrug-resistant and extensively drug-resistant tuberculosis.
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A safety and efficacy study provided experience on the use of ZYVOX in pediatric patients for the treatment of nosocomial pneumonia, complicated skin and skin structure infections, catheter-related bacteremia, bacteremia of unidentified source, and other infections due to Gram-positive bacterial pathogens, including methicillin-resistant and -susceptible Staphylococcus aureus and vancomycin-resistant Enterococcus faecium.
It does not provide medical advice, diagnosis or treatment.
This information has also been included in the ADVERSE REACTIONS section and Patient Information sheet.
Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine. Medicines and their possible side effects can affect individual people in different ways.
The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.
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Special populationsRenal impairment: After single doses of 600 mg, there was a 7-8 fold increase in exposure to the two primary metabolites of linezolid in the plasma of patients with severe renal insufficiency i.
During your treatment with linezolid, do not start or stop using any other medications unless your doctor tells you to, especially: Where can I get more information.