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Moexipril: ACE inhibitors may enhance the hypoglycemic effects of insulin or other antidiabetic agents by improving insulin sensitivity. Monoamine oxidase inhibitors: Animal data indicate that monoamine oxidase inhibitors MAO inhibitors may stimulate insulin secretion. Animal data indicate that monoamine oxidase inhibitors MAO inhibitors may stimulate insulin secretion. Moxifloxacin: Disturbances of blood glucose, including hyperglycemia and hypoglycemia, have been reported in patients treated concomitantly with quinolones and an antidiabetic agent.
Nadolol: Beta-blockers can prolong hypoglycemia or can promote hyperglycemia. Nandrolone Decanoate: Exogenously administered androgens have variable effects on blood glucose control in patients with diabetes mellitus. Nebivolol: Beta-blockers can prolong hypoglycemia or can promote hyperglycemia.
Beta-blockers can prolong hypoglycemia or can promote hyperglycemia.
A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Subscribe to the WebMD Daily, and you'll get today's top health news and trending topics, and the latest and best information from WebMD. What conditions does Glucovance treat. Side Effects See also Warning section. In the US -Call your doctor for medical advice about side effects.
List Glucovance side effects by likelihood and severity. What should I know regarding pregnancy, nursing and administering Glucovance to children or the elderly.
Interactions See also How To Use section. Does Glucovance interact with other medications. Should I avoid certain foods while taking Glucovance. Overdose If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911.
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This should be taken into consideration in patients with impaired glucose tolerance or diabetes mellitus who are receiving antidiabetic agents.
Monitor blood glucose and for changes in glycemic control and be alert for evidence of an interaction. Carbonic anhydrase inhibitors frequently decrease serum bicarbonate and induce non-anion gap, hyperchloremic metabolic acidosis.
Use these drugs with caution in patients treated with metformin, as the risk of lactic acidosis may increase. Monitor electrolytes and renal function. Acitretin: Retinoids have been reported to cause changes in blood sugar control in diabetics. In a study of 7 healthy male volunteers, acitretin treatment potentiated the blood glucose lowering effect of glibenclamide a sulfonylurea similar to chlorpropamide in 3 of the 7 subjects.
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May also decrease rate of hepatic glucose production, increase insulin receptor sensitivity, and increase number of insulin receptorsTo view formulary information first create a list of plans.
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Pharmacology Mechanism of Action Initial effect is to increase beta-cell insulin secretion May also decrease rate of hepatic glucose production, increase insulin receptor sensitivity, and increase number of insulin receptorsPharmacokinetics Onset: 2-3 hr Metabolites: 4-trans-hydroxyglyburide, 3-cis-hydroxyglyburide active Half-Life Glyburide: Approx.
To view formulary information first create a list of plans. NC NOT COVERED - Drugs that are not covered by the plan.
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Severe hypoglycemic reactions with coma, seizure, or other neurological impairment occur infrequently, but constitute medical emergencies requiring immediate hospitalization. Patients should be closely monitored for a minimum of 24 to 48 hours, since hypoglycemia may recur after apparent clinical recovery. Therefore, hemodialysis may be useful for removal of accumulated drug from patients in whom metformin overdosage is suspected.
Glucovance should be given with meals and should be initiated at a low dose, with gradual dose escalation as described below, in order to avoid hypoglycemia largely due to glyburidereduce GI side effects largely due to metforminand permit determination of the minimum effective dose for adequate control of blood glucose for the individual patient.
With initial treatment and during dose titration, appropriate blood glucose monitoring should be used to determine the therapeutic response to Glucovance and to identify the minimum effective dose for the patient. Thereafter, HbA1c should be measured at intervals of approximately 3 months to assess the effectiveness of therapy.
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Animal data indicate that monoamine oxidase inhibitors MAO inhibitors may stimulate insulin secretion.
Medroxyprogesterone: Patients receiving antidiabetic agents like metformin should be closely monitored for signs indicating changes in diabetic control when therapy with progestins is instituted or discontinued.
High blood sugar can be lowered by diet and exercise, a number of oral medications, and insulin injections.
Lamotrigine: Coadministration of metformin and lamotrigine may decrease metformin clearance, resulting in increased plasma concentrations and the potential for adverse events, including hypoglycemia.
This warning is based on the study conducted by the University Group Diabetes Program UGDPa long-term prospective clinical trial designed to evaluate the effectiveness of glucoselowering drugs in preventing or delaying vascular complications in patients with non-insulindependent diabetes. Despite controversy regarding the interpretation of these resultsthe findings of the UGDP study provide an adequate bas is for this warning.
Such decrease, possibly due to interference with B12 absorption from the B12-intrinsic factor complex is, however, very rarely associated with anemia and appears to be rapidly reversible with discontinuation of metformin or vitamin B supplementation. See Pregnancy: Teratogenic Effects : Pregnancy Category B.
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DownsidesThere's a higher risk of low blood sugar episodes than with other kinds of oral diabetes medications.
Take care, and as always, be well.