Generic Glucovance

Generic Name: Generic glucovance

What is Generic Glucovance?

You may report side effects to the FDA at 1-800-FDA-1088. Especially tell your doctor if you take:acetazolamide Diamox amiloride Midamor, in Moduretic angiotensin-converting enzyme ACE inhibitors such as benazepril Lotensincaptopril Capotenenalapril Vasotecfosinopril Monoprillisinopril Prinivil, Zestrilmoexipril Univascperindopril Aceonquinapril Accuprilramipril Altaceand trandolapril Mavik anticoagulants 'blood thinners' such as warfarin Coumadin aspirin or other nonsteroidal anti-inflammatory drugs NSAIDs such as ibuprofen Advil, Motrin or naproxen Aleve, Naprosyn beta-blockers such as atenolol Tenorminlabetalol Normodynemetoprolol Lopressor, Toprol XLnadolol Corgardand propranolol Inderal calcium channel blockers such as amlodipine Norvascdiltiazem Cardizem, Dilacor, Tiazac, othersfelodipine Plendilisradipine DynaCircnicardipine Cardenenifedipine Adalat, Procardiaor verapamil Calan, Isoptin, Verelan chloramphenicolcimetidine Tagamet clarithromycin Bi axin cyclosporine Neoral, Sandimmune digoxin Lanoxin disop yramide Norpace diuretics 'water pills' fluconazole Diflucan fluoxetine Prozac, Sarafem furosemide Lasix hormone replacement therapyinsulin or other medications for diabetesisoniazidMAO inhibitors such as isocarboxazid Marplanphenelzine Nardilselegiline Eldepryl, Emsam, Zelaplarand tranylcypromine Parnate medications for allergies, asthma, and coldsmedications for mental illness and nauseamiconazole Lotrimin, Monistat, others morphine MS Contin, others niacinoral contraceptives birth control pills oral steroids such as dexamethasone Decadron, Dexonemethylprednisolone Medroland prednisone Deltasone phenytoin Dilantin Phenytek probenecid Benemid, in Colbenemid procainamide Procanbid quinidinequininequinolone and fluoroquinolone antibiotics such as cinoxacin Cinobacciprofloxacin Ciproenoxacin Penetrexgatifloxacin Tequinlevofloxacin Levaquinlomefloxacin Maxaquinmoxifloxacin Aveloxnalidixic acid NegGramnorfloxacin Nor n and alatrofloxacin combination Trovan ranitidine Zantac rifampinsalicylate pain relievers such as choline magnesium trisalicylate, choline salicylate Arthropandiflunisal Dolobidmagnesium salicylate Doan's, othersor salsalate Argesic, Disalcid, Salgesic sulfa antibiotics such as cotrimoxazole Bactrim, Septra sulfasalazine Azulfidine thyroid medicationstopiramate Topamax triamterene in Dyazide, Maxzide, others trimethoprim Primsol vancomycin Vancocin, others zonisamide Zonegran This is not a complete list of Glucovance drug interactions.

Glucovance PrecautionsBack to TopSerious side effects have been reported with Glucovance including the following:Lactic acidosis. Tell your healthcare provider right away if you have some or all of the following symptoms of lactic acidosis. Extreme tirednessWeakness or discomfortUnusual or unexpected stomach painDecreased appetiteDeep and rapid breathing or shortness of breathDizzinessLightheadednessFast or slow heart beatFlushing of the skinMuscle painFeeling coldHypoglycemia low blood sugar.

Tell your healthcare provider right away if you have some or all of the following symptoms of hypoglycemia. LightheadednessDizzinessShakinessHungerChest painRashYellowing of the skin or eyesLight-colored stoolsDark urinePain in the upper right part of the abdomenUnusual bleeding or bruisingFeverSore throatSwelling of the eyes, face, tongue, or throatGlucovance can cause dizziness. Do not take Glucovance if you:are allergic to Glucovance or to any of its ingredientshave liver or kidney diseasehave acute or chronic metabolic acidosishave congestive heart failure that is treated with digoxin Lanoxin or furosemide Lasix drink alcohol excessivelyare dehydratedare going to have procedures such as an X-ray with injectable contrast agentsare going to have surgeryhave a heart attack, stroke, or severe infectionare older than 80 years and have not had your kidney function testedare taking bosentan Tracleer Glucovance Food InteractionsBack to TopMedications can interact with certain foods.

In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Glucovance, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MDBack to TopBefore taking Glucovance, tell your doctor about all of your medical conditions.

Glyburide is a P-glycoprotein P-gp substrate. Olaparib is an in vitro P-gp inhibitor, although the clinical relevance is unknown. Use caution if coadministration of olaparib with metformin is necessary, due to an increased risk of metformin-related adverse reactions.

Metformin is an OCT2 substrate. Olaparib is an in vitro OCT2 inhibitor, although the clinical relevance is unknown. Olmesartan: Angiotensin II receptor antagonists ARBs may enhance the hypoglycemic effects of antidiabetic agents by improving insulin sensitivity. If these drugs are given together, closely monitor blood glucose concentrations and for signs of lactic acidosis i.

If these drugs are administered concurrently, blood glucose should be monitored closely. Orlistat: Changes in dietary intake and weight loss induced by orlistat may improve metabolic control in obese diabetic patients, which may be additive to the effects of metformin.

Lower blood glucose as a result of orlistat-induced changes in body composition may necessitate a dosage reduction of metformin with time. Changes in dietary intake and weight loss induced by orlistat may improve metabolic control in diabetic patients. Lower blood glucose may necessitate a dosage reduction of antidiabetic agents. Ospemifene: Administer glyburide with ospemifene with considerable caution.

Use of ospemifene with glyburide may lead to increased exposure of either drug. Oxandrolone: Exogenously administered androgens have variable effects on blood glucose control in patients with diabetes mellitus.

How should I take Generic Glucovance?

Nifedipine appears to enhance the absorption of metformin. Nitazoxanide: The active metabolite of nitazoxanide, tizoxanide, is highly bound to plasma proteins. Caution should be exercised when administering nitazoxanide concurrently with other highly plasma protein-bound drugs with narrow therapeutic indices because competition for binding sites may occur.

Non-Ionic Contrast Media: Metformin and combination products containing metformin should be temporarily discontinued prior to the administration of iodinated radiopaque contrast agents.

Lactic acidosis has been reported in patients taking metformin that experience nephrotoxicity after iodinated contrast media. Nonsteroidal antiinflammatory drugs: NSAIDs may enhance hypoglycemia in diabetic patients via inhibition of prostaglandin synthesis, which indirectly increases insulin secretion.

If NSAIDs are administered or discontinued in patients receiving oral antidiabetic agents, patients should be monitored for hypoglycemia or loss of blood glucose control.

What should I avoid while taking Generic Glucovance?

Capecitabine: Use caution if coadministration of capecitabine with glyburide is necessary, and monitor for an increase in glyburide-related adverse reactions such as hypoglycemia. Captopril: ACE inhibitors may enhance the hypoglycemic effects of insulin or other antidiabetic agents by improving insulin sensitivity. Carbonic anhydrase inhibitors: Carbonic anhydrase inhibitors may alter blood sugar.

Cariprazine: Patients taking sulfonylureas should be closely monitored for worsening glycemic control when an atypical antipsychotic is instituted. Carteolol: Beta-blockers can prolong hypoglycemia or can promote hyperglycemia. Carvedilol: Beta-blockers can prolong hypoglycemia or can promote hyperglycemia.

Generic Glucovance side effects

Somatropin increases blood glucose concentrations thereby decreasing the hypoglycemic effect of antidiabetic agents. Monitor for signs indicating loss of diabetic control when therapy with somatropin is instituted. Sotalol: Beta-blockers can prolong hypoglycemia or can promote hyperglycemia. Sparfloxacin: Disturbances of blood glucose, including hyperglycemia and hypoglycemia, have been reported in patients treated concomitantly with quinolones and an antidiabetic agent.

Disturbances of blood glucose, including hyperglycemia and hypoglycemia, have been reported in patients treated concomitantly with quinolones like sparfloxacin and an antidiabetic agent like metformin.

Monitor blood glucose when sparfloxacin and metformin are coadministered. Sulfacetamide: Sulfonamides may cause photosensitization and may increase the photosensitizing effects of sulfonylureas.

Common Generic Glucovance ide effects may include:

  • The atypical antipsychotics have been associated with metabolic changes, including hyperglycemia, diabetic ketoacidosis, hyperosmolar, hyperglycemic states, and diabetic coma.

  • This information is for educational purposes only, and not meant to provide medical advice, treatment, or diagnosis.

  • Disturbances of blood glucose, including hyperglycemia and hypoglycemia, have been reported in patients treated concomitantly with quinolones like sparfloxacin and an antidiabetic agent like metformin.

  • Glucovance combines glyburide and metformin hydrochloride, 2 antihyperglycemic agents with complementary mechanisms of action, to improve glycemic control in patients with type 2 diabetes.

Your doctor can prescribe a glucagon emergency injection kit and tell you how to use it. Also watch for signs of high blood sugar hyperglycemia such as increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss. Check your blood sugar carefully during times of stress, travel, illness, surgery or medical emergency, vigorous exercise, or if you drink alcohol or skip meals. These things can affect your glucose levels and your dose needs may also change.

Do not change your Glucovance dose or dosing schedule without your doctor's advice.

Where can I get more information?

  • The combination of itraconazole and oral antidiabetic agents has resulted in severe hypoglycemia.

  • Further, the accuracy, currency and completeness of the information available on this Web site cannot be guaranteed.