Generic Name: Glucovance
What is Glucovance?
Tacrolimus has been reported to cause hyperglycemia. Furthermore, tacrolimus has been implicated in causing insulin-dependent diabetes mellitus in patients after renal transplantation. Patients should be monitored for worsening of glycemic control if Tacrolimus is initiated in patients receiving antidiabetic agents. Tegaserod: Because tegaserod can enhance gastric emptying in diabetic patients, blood glucose can be affected, which, in turn, may affect the clinical response to antidiabetic agents.
The dosing of antidiabetic agents may require adjustment in patients who receive GI prokinetic agents concomitantly. Tegaserod can enhance gastric emptying in diabetic patients, blood glucose can be affected, which, in turn, may affect the clinical response to antidiabetic agents. Telaprevir: Close clinical monitoring is advised when administering glyburide with telaprevir due to an increased potential for glyburide-related adverse events.
If glyburide dose adjustments are made, re-adjust the dose upon completion of telaprevir treatment. Telmisartan: Angiotensin II receptor antagonists ARBs may enhance the hypoglycemic effects of antidiabetic agents by improving insulin sensitivity.
Temsirolimus: Use caution if coadministration of temsirolimus with glyburide is necessary, and monitor for an increase in glyburide-related adverse reactions including hypoglycemia.
Temsirolimus is a P-glycoprotein P-gp inhibitor in vitro, and glyburide is a P-gp substrate. Pharmacokinetic data are not available for concomitant use of temsirolimus with P-gp substrates, but exposure to glyburide is likely to increase.
Penbutolol: Beta-blockers can prolong hypoglycemia or can promote hyperglycemia. Pentamidine: Pentamidine can be harmful to pancreatic cells. This effect may lead to hypoglycemia acutely, followed by hyperglycemia with prolonged pentamidine therapy.
Patients on antidiabetic agents should be monitored for the need for dosage adjustments during the use of pentamidine. Pentoxifylline: Pentoxiphylline has been used concurrently with antidiabetic agents without observed problems, but it may enhance the hypoglycemic action of antidiabetic agents. Patients should be monitored for changes in glycemic control while receiving pentoxifylline in combination with antidiabetic agents.
Perindopril: ACE inhibitors may enhance the hypoglycemic effects of insulin or other antidiabetic agents by improving insulin sensitivity. Phenelzine: Animal data indicate that monoamine oxidase inhibitors MAO inhibitors may stimulate insulin secretion. Phenothiazines: The phenothiazines, especially chlorpromazine, may increase blood sugar.
Patients should be closely monitored for worsening glycemic control when any of these antipsychotics is instituted. In addition, concomitant use may increase the risk for phototoxicity.
The phenothiazines may increase blood sugar.
How should I take Glucovance?
This should be taken into consideration in patients with impaired glucose tolerance or diabetes mellitus who are receiving antidiabetic agents. Monitor blood glucose and for changes in glycemic control and be alert for evidence of an interaction. Carbonic anhydrase inhibitors frequently decrease serum bicarbonate and induce non-anion gap, hyperchloremic metabolic acidosis.
Use these drugs with caution in patients treated with metformin, as the risk of lactic acidosis may increase. Monitor electrolytes and renal function. Acitretin: Retinoids have been reported to cause changes in blood sugar control in diabetics.
What should I avoid while taking Glucovance?
Beware of caffeine, sugary foods, spices, exercise, sleep, alcohol, and stress because these can all impact blood sugar levels and increase diabetes complicationsDo you love salt. Take the online Salt Quiz to get the facts about dietary salts and sodium in fruits, vegetables, processed foods, snacks and soups. Type 2 diabetes non-insulin dependent is caused by: Eating a lot of foods and drinking beverages with simple carbohydrates pizza, white breads, pastas, cereals, pastries, etc.
Consuming too many products with artificial sweeteners We found out that they are bad for us. Lack of activity Exercise Stress Genetics While the signs and symptoms of both types of diabetes are the same, which include: Increased urination Increased hunger Increased thirst Unexplained weight loss. Symptoms of type 2 diabetes are often subtle, but may include: Fatigue Urine odor Unintentional weight gain or loss Frequent urination Dark skin under the chin, armpits, or groin Type 2 diabetes is diagnosed by a blood test.
Learn about type 2 diabetes warning signs, symptoms, diagnosis, and treatment options. Read how diet and exercise can help manage type 2 diabetes.
Glucovance side effects
According to the Beers Criteria, glyburide is considered a potentially inappropriate medication PIM for use in geriatric patients and should be avoided due to a greater risk of severe and prolonged hypoglycemia in older adults than in younger adult patients. The federal Omnibus Budget Reconciliation Act OBRA regulates medication use in residents of long-term care facilities LTCFs.
According to OBRA, the use of antidiabetic medications should include monitoring e. Sulfonylureas such as glyburide can cause SIADH and result in hyponatremia. Metformin has been associated with lactic acidosis, which is more likely to occur under the following conditions: serum creatinine of 1. Premenopausal anovulatory females with insulin resistance i. The American College of Obstetrician and Gynecologists recommends insulin as the therapy of choice to maintain blood glucose as close to normal as possible during pregnancy in patients with type 1 or 2 diabetes mellitus, and, if diet therapy alone is not successful, for those patients with gestational diabetes.
Common Glucovance ide effects may include:
Hyperglycemia and hypoglycemia have been reported in patients treated concomitantly with quinolones and antidiabetic agents.
Stomach symptoms that occur after the first days of your treatment may be a sign of lactic acidosis.
Generally, elderly, debilitated, and malnourished patients should not be titrated to the maximum dose of Glucovance to avoid the risk of hypoglycemia.
Ionic Contrast Media: Metformin and combination products containing metformin should be temporarily discontinued prior to the administration of iodinated contrast media.
If the patient's current combination therapy e. There are advantages for combining glyburide and metformin: 1 lower doses are required for glucose control, 2 fewer adverse effects may occur, and 3 increase in patient acceptance and compliance. In addition, patients should maintain a good diet and exercise program, as well as regular blood glucose monitoring.
Where can I get more information?
I believe most of us Type II's are better served with low carbing, some exercise, and glucophage and Byetta or anything else that slows the rush of food into our systems.
Certain medications used concomitantly with metformin may also increase the risk of lactic acidosis.